Apparatus for the monitoring and control of respiration

• US 5,520,192 A
• Filed: 11/21/1994
• Issued: 05/28/1996
• Est. Priority Date: 12/23/1991
• Status: Expired due to Fees

• Current Assignee: Imperial College of Science Technology & Medicine (Imperial College London)
• Original Assignee: Imperial College of Science Technology & Medicine (Imperial College London)
• Inventors: Bignall, Simon, Kitney, Richard I.
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): GILBERT, SAMUEL G
• Application Number:
  US08/345,332
• Time in Patent Office: 554 Days
• Field of Search: 128/716, 128/720-727, 128/670, 128/671, 128/204.21, 128/204.23, 128/202.22
• US Class Current: 600/529
• CPC Class Codes: A61B 5/08 Detecting, measuring or recording devices for evaluating the respiratory organs A61B5/0205 takes precedence
• CPC Class Codes: A61M 16/0051 with alarm devices
• CPC Class Codes: A61M 16/026 specially adapted for predicting, e.g. for determining an information representative of a flow limitation during a ventilation cycle by using a root square technique or a regression analysis
• CPC Class Codes: A61M 2016/0021 with a proportional output signal, e.g. from a thermistor
• CPC Class Codes: A61M 2230/04 Heartbeat characteristics, e.g. ECG, blood pressure modulation
• CPC Class Codes: A61M 2230/08 Other bio-electrical signals
• CPC Class Codes: A61M 2230/60 Muscle strain, i.e. measured on the user

Abstract

A respiration monitor for measuring the respiration of a subject on a mechanical ventilator comprises first transducer means arranged to produce a first signal representative of a respiration status of the subject, second transducer means arranged to produce a second signal representative of a cyclical status of the mechanical ventilator, and processor means arranged to receive said first and second signals and to produce an output signal dependent upon the relative phase of said first and second signals. The invention extends to a method of monitoring, and also to a method of determining the rate at which a mechanical ventilator should be set in order to achieve 1:1 entrainment with spontaneous respiratory efforts.

Claims

1. A device for monitoring a subject'"'"'s physiological status comprising:

first transducer means for producing a first signal representative of the physiological status;

respiration apparatus having an effect on the physiological status;

second transducer means for producing a second signal representative of a cyclical status of said respiration apparatus; and

processor means, coupled to receive said first and second signals, for producing an output signal dependent upon a relative phase of said first and second signals.

2. A device as claimed in claim 1, wherein said respiration apparatus is an artificial physiological stimulation apparatus including a mechanical ventilator, said device further comprising:

a respiration monitor, connected to said processor means, for displaying a respiration of said subject.

3. A device according to claim 2, wherein said first transducer means is a means for measuring spontaneous respiratory efforts of said subject.

4. A device according to claim 3, wherein said first transducer means includes an abdominal movement sensor.

5. A device according to claim 3, wherein said processor means comprises means for determining said subject'"'"'s response to said external apparatus by subtracting an ensemble average of effects due to said mechanical ventilator from said first signal.

6. A device according to claim 5, wherein said processor means comprises means for automatically recalculating said ensemble average at periodic intervals, and for repeating said subtraction.

7. A device according to claim 3, wherein said processor means comprises means for determining a ratio of an amplitude of said first signal to an amplitude of said second signal.

8. A device according to claim 3, further comprising display means for displaying a frequency tracking locus of plotted phasors representing a relative difference between said first signal and said second signal.

9. A device according to claim 3, further comprising:

calculation means for calculating a path length index (PLI) determined from said relative phase of said first and second signals according to a formula ##EQU5## where n is a number of phasors, M_i is a magnitude from an origin to a tip of said k^th phasor, said phasors representing said relative phase of said first and second signals; and

display means for displaying said calculated path length index.

10. A device according to claim 9, wherein said display means comprises means for displaying a trend of said PLI over a period of time.

11. A device according to claim 9, further comprising alarm means for actuating an alarm if said PLI goes outside a predetermined range.

12. A device according to claim 2, wherein said first transducer means includes an inductance plethysmograph.

13. A device according to claim 2, wherein said first transducer means includes a transthoracic impedance pneumograph.

14. A device according to claim 2, wherein said first transducer means includes a pressure sensor.

15. A device according to claim 2, wherein said first transducer means includes a diaphragmatic electromyogram device.

16. A device according to claim 2, wherein said first transducer means includes a pneumotachograph.

17. A device according to claim 2, wherein said second transducer means includes an airway pressure sensor.

18. A device according to claim 2, further comprising first filter means for low-pass filtering said first signal prior to receipt by said processor means.

19. A device according to claim 18, wherein said device further comprises second filter means for low-pass filtering said second signal prior to receipt by said processor means.

20. A device according to claim 2, further comprising feedback circuit means, coupled to said processor means and said mechanical ventilator, for controlling said mechanical ventilator in dependence on said relative phase of said first and second signals.

21. A device according to claim 2, further comprising feedback circuit means, coupled to said processor means and said mechanical ventilator, for controlling said mechanical ventilator in dependence on a path length index (PLI), said path length index being determined from said relative phase of said first and second signals according to a formula ##EQU6## where n is a number of phasors, M_i is a magnitude from an origin to a tip of said k^th phasor, said phasors representing said relative phase of said first and second signals.

22. A method for monitoring a physiological status of a subject, said method comprising the steps of:

producing a first signal representative of the physiological status of said subject using first transducer means;

artificially respirating said subject with a respiration device to affect the physiological status of said subject;

producing a second signal representative of a cyclical status of said respiration device using second transducer means; and

producing an output signal which is dependent upon a relative phase of said first and second signals.

23. A method for monitoring a physiological status of a subject provided with artificial physiological stimulation, said method comprising the steps of:

producing a first signal representative of the physiological status of said subject;

producing a second signal representative of a cyclical status of said artificial physiological stimulation;

producing an output signal which is dependent upon a relative phase of said first and second signals; and

monitoring respiration of said subject.

24. A method according to claim 23, wherein said step of producing said first signal includes measuring spontaneous respiratory efforts of said subject.

25. A method according to claim 24, further including a step of measuring said subject'"'"'s response to said artificial physiological stimulation by subtracting an ensemble average of effects due to said artificial physiological stimulation from said first signal.

26. A method according to claim 25, further including the steps of:

automatically recalculating said ensemble average at periodic intervals; and

repeating said subtraction.

27. A method according to claim 24, wherein said artificial physiological stimulation includes a mechanical ventilator, said method further including the steps of:

determining a frequency of said mechanical ventilator for a 1;

1 entrainment with the said subject'"'"'s spontaneous respiratory efforts by effecting an intermediate mandatory ventilation over a predefined period, and

determining said frequency according to a spontaneous inter breath interval during said period.

28. A method according to claim 24, wherein said output signal producing step produces said output signal in dependence upon a ratio of an amplitude of a spontaneous breath of said subject to an amplitude of said artificial physiological stimulation.

29. A method according to claim 24, further including a step of displaying a frequency tracking locus of plotted phasors representing a relative difference between said first signal and said second signal.

30. A method according to claim 24, further including a step of calculating and displaying a path length index (PLI), said path length index being determined from said relative phase of said first and second signals according to a formula ##EQU7## where n is a number of phasors, M_i is a magnitude from an origin to a tip of said k^th phasor, said phasors representing said relative phase of said first and second signals.

31. A method according to claim 30, further including a step of displaying a trend of said PLI over a period of time.

32. A method according to claim 30, further including a step of operating alarm means if said PLI goes outside a predefined range.

33. A method according to claim 23, wherein said artificial physiological stimulation includes a mechanical ventilator, said method further including a step of controlling said mechanical ventilator in dependence on said relative phase of said first and second signals.

34. A method according to claim 23, wherein said artificial physiological stimulation includes a mechanical ventilator, said method further including a step of controlling said mechanical ventilator in dependence upon a path length index (PLI), said path length index being determined from said relative phase of said first and second signals according to a formula ##EQU8## where n is a number of phasors, M_i is a magnitude from an origin to said k^th phasor, said phasors representing said relative phase of said first and second signals.

35. A method according to claim 23, further including a step of filtering said first signal.

36. A method according to claim 25, further including a step of filtering said second signal.