Support layer for enzyme electrode laminated membranes
First Claim
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1. Laminated membrane for use in a polarographic cell assembly for assay of an analyte in solution, said laminated membrane comprising:
- an outer layer having pore sizes of greater than about 200 Angstrom units in diameter and less than about 750 Angstrom units in diameter therein and having a porosity of from about 0.005-0.2%;
an inner layer, andan enzyme layer disposed between said outer layer and said inner layer.
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Abstract
Improved Newman type enzyme containing laminated membranes are disclosed for use in conjunction with polarographic cells to measure analyte concentration in solutions. The laminated membranes comprise a semipermeable outer, support layer including super large pores of greater than about 200 Å in diameter. The outer layer preferably comprises pore sizes of about 380-750 Å in diameter and has a percentage porosity of about 0.005-0.2%.
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Citations
16 Claims
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1. Laminated membrane for use in a polarographic cell assembly for assay of an analyte in solution, said laminated membrane comprising:
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an outer layer having pore sizes of greater than about 200 Angstrom units in diameter and less than about 750 Angstrom units in diameter therein and having a porosity of from about 0.005-0.2%; an inner layer, and an enzyme layer disposed between said outer layer and said inner layer.
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2. Laminated membrane for use in a polarographic cell assembly for assay of an analyte in solution, said laminated membrane comprising:
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an outer layer having pore sizes on the order of about 380 to 750 Angstrom units in diameter therein and having a porosity of from about 0.005 to 2%; an inner layer, and an enzyme layer disposed between said outer layer and said inner layer. - View Dependent Claims (3, 4, 5)
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6. Laminated membrane for use in a polarographic cell assembly for assay of an analyte selected from the group consisting of glucose and lactate in solution, said assembly comprising a reference electrode and a sensor electrode, said laminated membrane positioned proximate said sensor electrode and comprising:
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an outer layer of about 5 to 7 microns thick and having pore sizes of greater than about 200 Angstrom units in diameter and less than about 750 Angstroms in diameter and a porosity of from about 0.005-2%; an inner layer of about 2 microns or less in thickness disposed adjacent said sensor electrode, and an enzyme layer disposed between said outer layer and said inner layer. - View Dependent Claims (7)
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8. Laminated membrane for use in a polarographic cell assembly for assay of an analyte selected from the group consisting of glucose and lactate in solution, said assembly comprising a reference electrode and a sensor electrode, said laminated membrane positioned proximate said sensor electrode and comprising:
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an outer layer of about 5 to 7 microns thick and having pore sizes of about 380 to 750 Angstrom units in diameter and a porosity of from about 0.005 to 0.2%, said outer layer being composed of a member selected from the group consisting of polycarbonate, regenerated cellulose and polyurethane polymers; an inner layer of about 2 microns or less in thickness disposed adjacent said sensor electrode, and an enzyme layer disposed between said outer layer and said inner layer. - View Dependent Claims (9, 10, 11)
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12. Laminated membrane for use in a polarographic cell assembly for assay of an analyte in solution, said laminated membrane comprising:
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an outer layer comprising a semi-permeable film having pore sizes of about 380-750 Angstrom units in diameter therein; an inner layer; and an enzyme layer disposed between said outer layer and said inner layer. - View Dependent Claims (13, 14, 15, 16)
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Specification