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Use of certain anionic surfactants to enhance antimicrobial effectiveness of ophthalmic compositions

  • US 5,520,920 A
  • Filed: 08/13/1993
  • Issued: 05/28/1996
  • Est. Priority Date: 08/28/1992
  • Status: Expired due to Term
First Claim
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1. A method of improving or enhancing the antimicrobial efficacy of an ophthalmic composition comprising a cationic antimicrobial, an anionic polyelectrolyte and an active ingredient, said method comprising adding to said composition an antimicrobial-enhancing amount of an anionic surfactant selected from the group consisting of:

  • a) a compound of formula;

    ##STR4## wherein;

    R1 =C4 -C27 saturated or unsaturated hydrocarbon;

    M=H or a pharmaceutically acceptable salt; and

    n=1, 2 or 3; and

    b) a compound of formula;

    ##STR5## wherein;

    R2 =C4 -C27 saturated or unsaturated hydrocarbon;

    M=H or a pharmaceutically acceptable salt; and

    n=1, 2 or 3.

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