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Vented vial method of minimizing contamination of freeze-dried products

  • US 5,522,155 A
  • Filed: 04/07/1995
  • Issued: 06/04/1996
  • Est. Priority Date: 08/19/1994
  • Status: Expired due to Fees
First Claim
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1. A process for freeze drying a material which comprises:

  • (a) filling a vial or bottle with product under sterile conditions;

    (b) attaching a cap or stopper to the mouth of the vial or bottle, in which the cap is shaped to form a vapor-tight seal with the mouth of the vial, and in which the cap or stopper has a venting port that comprises a passage in the cap or stopper, and a water vapor permeable, sterile barrier venting media located in the path of vapor travel through the venting port, and means for permitting the venting port to be opened or closed to the interior of the vial or bottle;

    (c) moving the venting port means to the open position;

    (d) freeze drying the product in the vial, allowing water vapor to escape through the venting media and the vent port;

    (e) sealing the vent port by pressing down on the stopper.

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