Control of a multi-channel drug infusion pump using a pharmacokinetic model
First Claim
1. A control for a multi-channel drug delivery system with which a plurality of drugs are selectively administered to a patient through a plurality of drug channels in accordance with a PK model, comprising:
- (a) a processor that is controlled in accordance with a set of program instructions that determine the steps implemented by said PK model;
(b) a memory, coupled to the processor, said memory storing the set of program instructions and a plurality of parameters used by the PK model;
(c) a display, coupled to the processor, on which are displayed the parameters and PK model data, including a concentration of a drug within the patient as a function of time;
(d) a user interface, coupled to the processor, said user interface enabling a user to input at least some of the plurality of parameters used by the PK model in controlling administration of each drug to the patient, and including identification means for identifying the drug that is being administered in each of the drug channels; and
(e) PK model prediction means, embodied in the processor executing said set of program instructions, for determining a drug concentration within the patient over time for each drug, as each drug is administered by the multi-channel drug delivery system, said PK model prediction means determining the drug concentration;
(i) during any interruption and after a termination of the drug delivery; and
(ii) regardless of any change in the drug channel through which any drug is delivered.
2 Assignments
0 Petitions
Accused Products
Abstract
A host controller (10) selectively predicts and controls drug concentrations for each of a plurality of channels delivered through multiple drug channels of a multi-channel drug delivery system. The host controller includes a controller (32) that is coupled to each drug channel of the multi-channel drug delivery system to receive actual drug delivery rate information. Delivery of each drug can be selectively separately controlled by a PK model (the same PK model for each channel or different PK models for different channels) to achieve either a desired setpoint for a blood plasma drug concentration or a setpoint for an effect compartment drug concentration. Control of the drug delivery by the PK model can be selectively interrupted during operation of the multi-channel drug delivery system, to switch to a manual mode in order to administer a bolus dose or a continuous infusion, and then, control of drug infusion using the PK model can be subsequently resumed. The blood plasma and/or effect compartment drug concentrations for any drug predicted in accordance with a PK model are selectively displayed to a user on an electroluminescent (EL) display (36), even during operation of the multi-channel drug delivery system in the manual mode, or after the drug delivery has been terminated. Prediction of drug concentration is tracked for each drug administered, enabling multiple drugs to successively administered in the same drug channel and control of a drug delivery by the PK model to continue when the drug channel used to administer the drug is changed.
-
Citations
55 Claims
-
1. A control for a multi-channel drug delivery system with which a plurality of drugs are selectively administered to a patient through a plurality of drug channels in accordance with a PK model, comprising:
-
(a) a processor that is controlled in accordance with a set of program instructions that determine the steps implemented by said PK model; (b) a memory, coupled to the processor, said memory storing the set of program instructions and a plurality of parameters used by the PK model; (c) a display, coupled to the processor, on which are displayed the parameters and PK model data, including a concentration of a drug within the patient as a function of time; (d) a user interface, coupled to the processor, said user interface enabling a user to input at least some of the plurality of parameters used by the PK model in controlling administration of each drug to the patient, and including identification means for identifying the drug that is being administered in each of the drug channels; and (e) PK model prediction means, embodied in the processor executing said set of program instructions, for determining a drug concentration within the patient over time for each drug, as each drug is administered by the multi-channel drug delivery system, said PK model prediction means determining the drug concentration; (i) during any interruption and after a termination of the drug delivery; and (ii) regardless of any change in the drug channel through which any drug is delivered. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
-
-
11. A control for a multi-channel drug delivery system with which any of a plurality of drugs are selectively administered to a patient through a plurality of drug channels in accordance with a PK model, comprising:
-
(a) a processor that is controlled in accordance with a set of program instructions that determine the steps of said PK model; (b) a memory, coupled to the processor, said memory storing the set of program instructions and a plurality of parameters used in the PK model; (c) a display, coupled to the processor, on which are displayed the parameters and data indicative of a state of the PK model; and (d) a user interface, coupled to the processor, said user interface enabling a user to input at least some of the plurality of parameters used by the PK model in controlling administration of a drug to the patient and including a selector switch that selectively determines whether the control uses the PK model to achieve either; (i) a desired blood plasma drug concentration;
or(ii) a desired effect compartment drug concentration. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
-
-
22. A control for a drug delivery system with which a drug is selectively administered to a patient in accordance with a PK model, comprising:
-
(a) a processor that is controlled in accordance with a set of program instructions that determine the steps of said PK model; (b) a memory, coupled to the processor, said memory storing the set of program instructions and a plurality of parameters used in the PK model; (c) a display, coupled to the processor, on which are displayed the parameters and data indicative of a state of the PK model; and (d) a user interface, coupled to the processor, said user interface enabling a user to input at least some of the plurality of parameters used by the PK model in controlling administration of the drug to the patient and including a selector switch that selectively determines whether the control uses the PK model to achieve; (i) a desired blood plasma drug concentration;
or(ii) a desired effect compartment drug concentration. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29)
-
-
30. A method for controlling a multi-channel drug delivery system with which a plurality of drugs are selectively administered to a patient through a plurality of drug channels in accordance with a PK model, comprising the steps of:
-
(a) enabling a user to input a plurality of parameters used by the PK model in controlling administration of a drug to the patient; (b) determining a drug concentration within the patient over time for each drug, as each drug is administered by the multi-channel drug delivery system; (i) during any interruption and after a termination of the drug delivery; and (ii) regardless of any change in the drug channel through which any drug is delivered. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 38)
-
-
39. A method for controlling a multi-channel drug delivery system with which a plurality of drugs are selectively administered to a patient in accordance with a PK model, comprising the steps of:
-
(a) enabling a user to input at least some of a plurality of parameters used by the PK model; (b) controlling administration of the plurality of drugs to the patient using the PK model; and (c) enabling the user to selectively determine whether the control uses the PK model to achieve either; (i) a desired blood plasma drag concentration;
or(ii) a desired effect compartment drug concentration. - View Dependent Claims (40, 41, 42, 43, 44, 45, 46, 47)
-
-
48. A method for controlling a drug delivery system with which a drug is administered to a patient in accordance with a PK model, comprising:
-
(a) enabling a user to input a plurality of parameters used by the PK model in controlling administration of the drug to the patient; (b) operating the drug delivery system to administer the drug to the patient in accordance with said parameters; and (c) selectively determining whether the control uses the PK model to achieve either; (i) a desired blood plasma drug concentration;
or(ii) a desired effect compartment drug concentration within the patient. - View Dependent Claims (49, 50, 51, 52, 53, 54, 55)
-
Specification