Method and apparatus for the prevention of arrhythmia by nerve stimulation

• US 5,522,854 A
• Filed: 05/19/1994
• Issued: 06/04/1996
• Est. Priority Date: 05/19/1994
• Status: Expired due to Term

• Current Assignee: Duke University
• Original Assignee: Duke University
• Inventors: Xhou, Xiaohong, Ideker, Raymond E.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): Jastrzab, Jeffrey R.
• Application Number:
  US08/245,980
• Time in Patent Office: 747 Days
• Field of Search: 607/4-6, 607/14, 607/48, 607/118, 607/119, 607/72, 128/702, 128/704, 128/705
• US Class Current: 607/6
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/3621 for treating or preventing abnormally high heart rate
• CPC Class Codes: A61N 1/3962 in combination with another heart therapy
• CPC Class Codes: A61N 1/39622 Pacing therapy

Abstract

Arrhythmia is prevented by detecting a high risk of arrhythmia and then stimulating afferent nerves to prevent the arrhythmia. By monitoring the sympathetic and parasympathetic nerve activity of a patient the risk of arrhythmia may be assessed. An apparatus for monitoring of parasympathetic and sympathetic nerve activity and stimulating the afferent nerves may be implanted in a patient. Furthermore, the apparatus and method for the prevention of arrhythmia may be combined with apparatus for the treatment of arrhythmia through electric shock to facilitate treatment and prevent reoccurrence of arrhythmia.

Claims

1. An implantable apparatus for combating heart arrhythmia in a subject, comprising:

means for monitoring a ratio of sympathetic nerve activity to parasympathetic nerve activity in said subject;

detection means for detecting a high risk of arrhythmia in said subject based on said ratio of sympathetic nerve activity to parasympathetic nerve activity; and

an electrical stimulator operably associated with said detection means and responsive to said detection means for stimulating afferent nerves in said subject upon detection of a high risk of arrhythmia.

2. The apparatus of claim 1 further comprising:

determining means for determining whether or not said stimulation has prevented an arrhythmia in said subject;

electric pulse means operably associated with said determining means for transmitting at least one electrical pulse to said subject to halt an arrhythmia which has occurred by delivery of an electric pulse; and

control means for controlling said electric pulse means to halt said arrhythmia when said determining means determines said stimulation did not prevent said arrhythmia.

3. The apparatus of claim 2 further comprising:

discrimination means responsive to said determining means for determining if an occurring arrhythmia is ventricular tachycardia; and

wherein said control means controls said electrical stimulator to stimulate said afferent nerves when said discrimination means determines said arrhythmia is ventricular tachycardia.

4. The apparatus of claim 2 wherein said electrical stimulator includes means for continuously stimulating said afferent nerves to prevent a reoccurrence of an arrhythmia after delivery of said electric pulse.

5. The apparatus of claim 2 wherein said electric pulse means comprises means for halting said arrhythmia selected from the group consisting of anti-tachycardia pacing, large cardioversion, and defibrilation shock.

6. An apparatus according to claim 1, wherein said means for monitoring the ratio of sympathetic nerve activity to parasympathetic nerve activity in said subject comprises means for monitoring heart rate variability in said subject.

7. The apparatus of claim 1 wherein said apparatus is sealed in a sterile container.

8. An apparatus according to claim 1, wherein said means for monitoring the ratio of sympathetic nerve activity to parasympathetic nerve activity in said subject comprises:

first monitoring means for monitoring sympathetic nerve activity in said subject;

second monitoring means for monitoring parasympathetic nerve activity in said subject;

comparing means connected to said first and second monitoring means for providing a comparison of said sympathetic and said parasympathetic nerve activity;

at least two monitoring leads electrically connected to said first and second monitoring means; and

a stimulating lead electrically connected to said electrical stimulator and contacting said subject for transmitting the stimulation from said electrical stimulator to the afferent nerves of said subject.

9. A method of combating heart arrhythmia in a subject comprising:

monitoring a ratio of sympathetic nerve activity to parasympathetic nerve activity in said subject;

detecting a high risk of arrhythmia in said subject based on the ratio of sympathetic and parasympathetic nerve activity; and

stimulating afferent nerves in said subject upon detection of a high risk of arrhythmia.

10. The method of combating heart arrhythmia of claim 9, said method further comprising:

determining whether or not said stimulation has prevented an arrhythmia in said subject; and

halting an arrhythmia which has occurred by delivery of an electric pulse when said stimulation has not prevented the arrhythmia.

11. The method of combating heart arrhythmia of claim 10 further comprising:

determining if an occurring arrhythmia is ventricular tachycardia; and

stimulating the afferent nerves during occurrence of the arrhythmia when the arrhythmia is ventricular tachycardia.

12. The method of combating heart arrhythmia of claim 10 further comprising:

continuously stimulating the afferent nerves to prevent a reoccurrence of an arrhythmia after delivery of an electric pulse to halt the arrhythmia.

13. The method of combating heart arrhythmia of claim 10 wherein the electric pulse for halting the arrhythmia is selected from the group comprising anti-tachycardia pacing, large cardioversion and defibrillation shock.

14. A method according to claim 9, wherein said step of monitoring the ratio of sympathetic nerve activity to parasympathetic nerve activity in said subject is carried out by monitoring heart rate variability in said subject.

15. An implantable apparatus for combating heart arrhythmia in a subject, comprising:

(a) monitoring means for monitoring sympathetic nerve activity and parasympathetic nerve activity, wherein said monitoring means monitors a ratio of said sympathetic nerve activity to said parasympathetic nerve activity, said monitoring means comprising;

first monitoring means for monitoring sympathetic nerve activity in said subject;

second monitoring means for monitoring parasympathetic nerve activity in said subject;

comparing means connected to said first and second monitoring means for comparing the ratio of sympathetic nerve activity to parasympathetic nerve activity;

(b) detection means for detecting a high risk of arrhythmia in said subject based on the ratio of nerve activity; and

(c) an electrical stimulator operably associated with said subject and said detection means and responsive to said detection means for stimulating afferent nerves in said subject upon detection of a high risk of arrhythmia.

16. A method of combating heart arrhythmia in a subject, comprising:

(a) monitoring the sympathetic nerve activity in said subject;

(b) monitoring the parasympathetic nerve activity in said subject;

(c) comparing said sympathetic nerve activity to said parasympathetic nerve activity to provide a ratio of said sympathetic nerve activity to said parasympathetic activity;

(d) detecting a high risk of arrhythmia in said subject based on the ratio of sympathetic and parasympathetic nerve activity; and

(e) stimulating afferent nerves in said subject upon detection of a high risk of arrhythmia.