Ultrasonic irradiation apparatus and processing apparatus based thereon

• US 5,523,058 A
• Filed: 05/12/1994
• Issued: 06/04/1996
• Est. Priority Date: 09/16/1992
• Status: Expired due to Term

• Current Assignee: Hitachi, Ltd.
• Original Assignee: Hitachi, Ltd.
• Inventors: Kawabata, Kenichi, Uchida, Kenko, Yasuda, Kenji, Hiraiwa, Atsushi, Wada, Yasuo, Umemura, Shinichiro
• Primary Examiner(s): McMahon, Timothy M.
• Assistant Examiner(s): Carpenter, Robert
• Application Number:
  US08/240,733
• Time in Patent Office: 754 Days
• Field of Search: 422/20, 422/128, 422/224, 134/1, 366/108, 366/114, 366/116, 366/127, 128/660.01, 128/660.03, 128/661.08, 310/320, 310/322, 310/334
• US Class Current: 422/128
• CPC Class Codes: A61B 17/22004 using mechanical vibrations, e.g. ultrasonic shock waves A61B17/225 takes precedence
• CPC Class Codes: A61N 2007/006 Lenses
• CPC Class Codes: A61N 2007/0078 with multiple treatment transducers
• CPC Class Codes: A61N 2007/0095 by modifying an excitation signal
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00

Abstract

By providing an ultrasonic irradiation apparatus for generating acoustic cavitation efficiently, it is intended to realize an ultrasonic therapeutic apparatus for generating the action of cavitation on a living body suitable for medical treatment of malignant tumors and medical treatment of thrombi and calculi, an ultrasonic diagnostic apparatus for generating cavitation for emphasizing an ultrasonic echo image such as a blood flow and utilizing the reflection capability of the cavitation, an ultrasonic chemical reaction accelerating apparatus, an ultrasonic cleaning apparatus or an ultrasonic sterilizing apparatus. Irradiation focus/code signals for defining irradiated acoustic fields of a fundamental wave and a second harmonic wave as well as focus positions/acoustic pressure distribution forms of the respective waves are applied from an irradiation unit main control circuit to drive phase generating circuits. Generated drive phases are applied to drive signal generating circuits, generated drive signals are applied to element drive circuits and a group of fundamental frequency elements and a group of second harmonic elements are driven. The drive phases are controlled such that the fundamental wave and second harmonic wave are superimposed on each other in a medium near a focal point, thus generating acoustic caviation locally and efficiently.

Claims

1. An apparatus for irradiating an object with a plurality of ultrasonic waves having mutually different frequencies, comprising:

first generating means for generating a fundamental ultrasonic wave having a fundamental frequency f_o ;

second generating means for generating a second harmonic ultrasonic wave having a second harmonic frequency 2f_o ;

driving means for driving the first generating means with a first electric signal for causing the first generating means to generate the fundamental ultrasonic wave substantially continuously, and for driving the second generating means with a second electric signal for causing the second generating means to generate the second harmonic ultrasonic wave substantially continuously; and

irradiating means for substantially simultaneously irradiating an object with the fundamental ultrasonic wave and the second harmonic ultrasonic wave so as to generate ultrasonic cavitation in the object or in a vicinity of the object by virtue of a synergistic effect occurring between the fundamental ultrasonic wave and the second harmonic ultrasonic wave.

2. An apparatus according to claim 1, wherein the first generating means and the second generating means are independent of one another;

and

wherein a frequency of the first electric signal is the fundamental frequency f_o, and a frequency of the second electric signal is the second harmonic frequency 2f_o.

3. An apparatus according to claim 2, wherein the first generating means and the second generating means have a common focal point;

and

wherein the object is disposed at the common focal point of the first generating means and the second generating means.

4. An apparatus according to claim 2, wherein the first generating means includes a first array of transducer elements for generating the fundamental ultrasonic wave, and the second generating means includes a second array of transducer elements for generating the second harmonic ultrasonic wave.

5. An apparatus according to claim 1, wherein the first generating means generates the fundamental ultrasonic wave and the second generating means generates the second harmonic ultrasonic wave such that an intensity of the second harmonic ultrasonic wave at the object is greater than 1/4 times and less than 4 times an intensity of the fundamental ultrasonic wave at the object.

6. An apparatus according to claim 1, wherein the first generating means generates the fundamental ultrasonic wave and the second generating means generates the second harmonic ultrasonic wave such that a phase relation between the fundamental ultrasonic wave and the second harmonic ultrasonic wave at the object is such that a waveform of the second harmonic ultrasonic wave at the object approximates-sin(4π

f_o t) with respect to time t when a waveform of the fundamental ultrasonic wave at the object is represented by sin(2π

f_o t).

7. An apparatus according to claim 1, further comprising an ultrasonic imaging unit for forming an ultrasonic echo image of the object, the ultrasonic imaging unit transmitting and receiving an ultrasonic wave having a frequency higher than the second harmonic frequency 2f_o.

8. An apparatus according to claim 7, wherein the fundamental ultrasonic wave and the second harmonic ultrasonic wave cause ultrasonic waves having frequencies which are even multiples of the second harmonic frequency f_o to be generated at the object;

and

wherein the ultrasonic imaging unit receives the ultrasonic waves having frequencies which are even multiples of the second harmonic frequency f_o.

9. An apparatus for irradiating an object with a plurality of ultrasonic waves having mutually different frequencies, comprising:

generating means for generating a fundamental ultrasonic wave having a fundamental frequency f_o, and for generating a second harmonic ultrasonic wave having a second harmonic frequency 2f_o ;

driving means for driving the generating means with an electric signal for causing the generating means to generate the fundamental ultrasonic wave and the second harmonic ultrasonic wave substantially continuously; and

irradiating means for substantially simultaneously irradiating an object with the fundamental ultrasonic wave and the second harmonic ultrasonic wave so as to generate ultrasonic cavitation in the object or in a vicinity of the object by virtue of a synergistic effect occurring between the fundamental ultrasonic wave and the second harmonic ultrasonic wave.

10. An apparatus according to claim 9, wherein the generating means includes a piezoelectric thickness mode vibrator element including a piezoelectric material and a material having substantially a same acoustic impedance as the piezoelectric material, the piezoelectric thickness mode vibrator element having an acoustic thickness of a half wavelength of the fundamental ultrasonic wave, and having a portion with an acoustic thickness of substantially 2/3 of the acoustic thickness of the piezoelectric thickness mode vibrator element which is driven piezoelectrically.

11. An apparatus according to claim 10, wherein the piezoelectric thickness mode vibrator element includes a layer of the piezoelectric material having an acoustic thickness of substantially 2/3 of the acoustic thickness of the piezoelectric thickness mode vibrator element, and a layer of the material having substantially the same acoustic impedance as the piezoelectric material having an acoustic thickness of substantially 1/3 of the acoustic thickness of the piezoelectric thickness mode vibrator element and being acoustically bonded to the layer of piezoelectric material;

and

wherein only the layer of the piezoelectric material having the acoustic thickness of substantially 2/3 of the acoustic thickness of the piezoelectric thickness mode vibrator element is driven piezoelectrically.

12. An apparatus according to claim 10, wherein the driving means includes:

a push-pull type switching circuit for driving the piezoelectric thickness mode vibrator element, the push-pull type switching circuit including a first switching element and a second switching element; and

control means for controlling the first switching element to turn on and the second switching element to turn off in first periods, and for controlling the first switching element to turn off and the second switching element to turn on in second periods alternating with the first periods;

wherein a ratio of a duration of each of the first periods to a duration of each of the second periods is substantially 1;

3 or 3;

1.

13. An apparatus according to claim 10, wherein the driving means includes:

a first constant potential source;

a second constant potential source;

a third constant potential source;

a switching circuit for driving the piezoelectric thickness mode vibrator element, the switching circuit including

first switching means coupled between the first constant potential source and the piezoelectric thickness mode vibrator element,

second switching means coupled between the second constant potential source and the piezoelectric thickness mode vibrator element, and

third switching means coupled between the third constant potential source and the piezoelectric thickness mode vibrator element; and

control means for controlling the first switching means, the second switching means, and the third switching means to turn on and off at predetermined timings.

14. An ultrasonic cleaning apparatus for ultrasonically cleaning an object with a plurality of ultrasonic waves having mutually different frequencies, comprising:

generating means for generating a fundamental ultrasonic wave having a fundamental frequency f_o, and for generating a second harmonic ultrasonic wave having a second harmonic frequency 2f_o ;

driving means for driving the generating means with at least one electric signal for causing the generating means to generate the fundamental ultrasonic wave and the second harmonic ultrasonic wave substantially continuously; and

cleaning means for ultrasonically cleaning an object substantially simultaneously with the fundamental ultrasonic wave and the second harmonic ultrasonic wave.

15. An apparatus according to claim 14, further wherein the cleaning means includes:

a cleaning tank having the object disposed therein; and

means for irradiating the object disposed in the cleaning tank substantially simultaneously with the fundamental ultrasonic wave and the second harmonic ultrasonic wave.

16. An apparatus according to claim 14, wherein the cleaning means includes:

a jetting unit for jetting a liquid onto the object; and

means for irradiating the liquid substantially simultaneously with the fundamental ultrasonic wave and the second harmonic ultrasonic wave before the liquid is jetted onto the object.

17. An apparatus according to claim 14, wherein the generating means generates the fundamental ultrasonic wave and the second harmonic ultrasonic wave such that an intensity of the second harmonic ultrasonic wave at the object is greater than 1/4 times and less than 4 times an intensity of the fundamental ultrasonic wave at the object.

18. An apparatus according to claim 14, wherein the generating means generates the fundamental ultrasonic wave and the second harmonic ultrasonic wave such that a phase relation α

between the fundamental ultrasonic wave and the second harmonic ultrasonic wave at the object is such that a waveform of the second harmonic ultrasonic wave at the object approximates sin(4π

f_o t+α

) with respect to time t when a waveform of the fundamental ultrasonic wave at the object is represented by sin(2π

f_o t) , where α

is a real number which is greater than (1/4)π and

less than (7/4)π

.

19. An apparatus according to claim 14, wherein the generating means includes a piezoelectric thickness mode vibrator element, the piezoelectric thickness mode vibrator element including a layer of a piezoelectric material, and a layer of a material having substantially a same acoustic impedance as the piezoelectric material and being acoustically bonded to the layer of piezoelectric material.

20. An apparatus according to claim 19, wherein a ratio of a time defined by dividing a thickness of the layer of piezoelectric material in a vibration direction of the piezoelectric thickness mode vibrator element by a speed of sound in the piezoelectric material to a time defined by dividing a thickness of the layer of material having substantially the same acoustic impedance as the piezoelectric material in the vibration direction by a speed of sound in the material having substantially the same acoustic impedance as the piezoelectric material is greater than 1 and less than 3.

21. An ultrasonic liquid sterilizing apparatus for ultrasonically sterilizing a liquid with a plurality of ultrasonic waves having mutually different frequencies, comprising:

generating means for generating a fundamental ultrasonic wave having a fundamental frequency f_o, and for generating a second harmonic ultrasonic wave having a second harmonic frequency 2f_o ;

driving means for driving the generating means with at least one electric signal for causing the generating means to generate the fundamental ultrasonic wave and the second harmonic ultrasonic wave substantially continuously; and

irradiating means for substantially simultaneously irradiating a liquid with the fundamental ultrasonic wave and the second harmonic ultrasonic wave so as to ultrasonically sterilize the liquid.

22. An apparatus according to claim 21, wherein the generating means includes a piezoelectric thickness mode vibrator element, the piezoelectric thickness mode vibrator element including a layer of a piezoelectric material, and a layer of a material having substantially a same acoustic impedance as the piezoelectric material and being acoustically bonded to the layer of piezoelectric material.

23. An apparatus according to claim 22, wherein a ratio of a time defined by dividing a thickness of the layer of piezoelectric material in a vibration direction of the piezoelectric thickness mode vibrator element by a speed of sound in the piezoelectric material to a time defined by dividing a thickness of the layer of material having substantially the same acoustic impedance as the piezoelectric material in the vibration direction by a speed of sound in the material having substantially the same acoustic impedance as the piezoelectric material is greater than 1 and less than 3.

24. An apparatus for irradiating an object with a plurality of ultrasonic waves having mutually different frequencies, comprising:

a piezoelectric vibrator element for generating a fundamental ultrasonic wave having a fundamental frequency f_o, and for generating a second harmonic;

ultrasonic wave having a second harmonic frequency 2f_o ;

a first driving circuit for driving the piezoelectric vibrator element such that the piezoelectric vibrator element generates the fundamental ultrasonic wave;

a second driving circuit for driving the piezoelectric vibrator element such that the piezoelectric vibrator element generates the second harmonic ultrasonic wave;

a first capacitance connected in parallel with the piezoelectric vibrator element, a total capacitance of the first capacitance and the piezoelectric vibrator element connected in parallel being C;

a first inductance having an inductance of (5/8)L connected between the first driving circuit and the first capacitance and the piezoelectric vibrator element connected in parallel, L being a total inductance which is resonant with the total capacitance C at the fundamental frequency f_o ; and

a second inductance having an inductance of (10/9)L and a second capacitance having a capacitance of (9/25)C connected in series between the second driving circuit and the first capacitance and the piezoelectric vibrator element connected in parallel.