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Device for local drug delivery and methods for using the same

  • US 5,523,092 A
  • Filed: 01/28/1994
  • Issued: 06/04/1996
  • Est. Priority Date: 04/14/1993
  • Status: Expired due to Fees
First Claim
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1. A device for the local delivery of a biologically active substance at a predetermined site in a natural tissue conduit in the mammalian body, the conduit having a luminal surface defining a lumen, comprising:

  • a) an elongated flexible tube of a preselected length and diameter having an external surface, a proximal end, an opposite distal end, and a lumen extending longitudinally therethrough interconnecting the proximal and distal ends with the proximal end defining an opening therethrough, the tube having a substance delivery segment adjacent the distal end and defining a plurality of substance delivery holes through the external surface which are in fluid communication with the lumen of the tube, the substance delivery segment being moveable among a first rest position wherein it has a first shape, a second position wherein it has a second substantially linear shape, and a third operative position wherein it has a third shape, the third position being intermediate the first and second positions;

    b) means for moving the substance delivery segment from its first position to its second position, the substance delivery segment tending to return to the first position when the moving means is no longer applied to the substance delivery segment; and

    c) means for introducing the substance into the lumen of the tube for delivery into the natural tissue conduit.

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