Ablation of blood thrombi by means of acoustic energy

• US 5,524,620 A
• Filed: 01/26/1994
• Issued: 06/11/1996
• Est. Priority Date: 11/12/1991
• Status: Expired due to Term

• Current Assignee: November Technologies Ltd.
• Original Assignee: November Technologies Ltd.
• Inventors: Rosenschein, Uri
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US08/186,639
• Time in Patent Office: 867 Days
• Field of Search: 601/2-4, 607/97, 606/128, 604/22, 128/660.03, 128/653.1
• US Class Current: 600/407
• CPC Class Codes: A61B 17/22004 using mechanical vibrations, e.g. ultrasonic shock waves A61B17/225 takes precedence
• CPC Class Codes: A61B 2017/00137 Details of operation mode
• CPC Class Codes: A61B 2017/00778 Operations on blood vessels A61B2017/22097, A61B2017/320741 take precedence

Abstract

A method and device for selective in vivo ablation of fresh blood thrombi by means of non-invasive focused high power acoustic energy. The method comprises applying a plurality of pulses of high energy acoustic waves or a continuous acoustic wave, focused at the location of a thrombus in a blood vessel, resulting in the ablation of the thrombus, and restoration of blood flow. There is also provided a device for the controlled generation and application of focused pulsed, or continuous, acoustic energy waves of predetermined energy and frequency.

Claims

1. A method for the non-invasive selective in vivo lysis of blood clots (thrombi) in mammals without damaging blood vessels containing said blood clots, said method comprising the step of applying, by means of an acoustic energy generator, high power focused acoustic energy in a focal area in which said blood vessels containing such thrombus are located, said focused acoustic energy being applied at a level above the cavitation threshold of the blood until the lysis is attained,

wherein said acoustic energy generator produces a predetermined ultrasound frequency in the range of about 1 KHz to 5 MHz.

2. A method according to claim 1, wherein said acoustic energy generator produces pulsed waves with a pulse duration in the 1 msec to 1 second range.

3. A method according to claim 1, where the acoustic energy generator produces said ultrasound frequency having an energy density at the focal area between about 0.1 to 100 W/cm².

4. A method according to claim 1, further comprising monitoring the ablation of the thrombus by application of the acoustic energy by X-ray.

5. A method according to claim 1 wherein said ultrasound frequency is produced by a piezoelectric ultrasound acoustic energy generator.

6. A method according to claim 1, further then comprising positioning the acoustic lens of the acoustic generator at a distance from about 5 cm to about 30 cm from the thrombus, in proximity of the skin of the patient.

7. A method according to claim 1, further comprising monitoring the ablation of the thrombus by application of the acoustic energy by ultrasound imaging.

8. A method according to claim 1 wherein said acoustic energy generator produces continuous acoustic waves.

9. A method for the non-invasive selective in vivo lysis of blood clots (thrombi) in mammals without damaging blood vessels containing said blood clots, said method comprising the step of applying, by means of an acoustic energy generator, high power focused acoustic energy in a focal area in which said blood vessels containing such thrombus are located, said focused acoustic energy being applied at a level above the cavitation threshold of the blood until the lysis is attained,

wherein said acoustic energy generator produces a shock wave.

10. The method of claim 9 wherein said shock wave is produced by a spark-type acoustic energy generator operating in the range of between 10 KV to 50 KV, with a pulse duration of 1 msec to about 100 msec.