Stilbene derivatives and pharmaceutical compositions containing them

• US 5,525,632 A
• Filed: 09/08/1994
• Issued: 06/11/1996
• Est. Priority Date: 09/08/1993
• Status: Expired due to Term

• Current Assignee: Ajinomoto Company Limited (Ajinomoto Co., Inc.)
• Original Assignee: Ajinomoto Company Limited (Ajinomoto Co., Inc.)
• Inventors: Obsumi, Koji, Tsuji, Takashi, Morinaga, Yoshihiro, Ohishi, Kazuo
• Primary Examiner(s): Raymond, Richard L.
• Application Number:
  US08/302,210
• Time in Patent Office: 642 Days
• Field of Search: 558/402, 564/443, 514/523, 514/646
• US Class Current: 514/646
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: C07C 205/35 having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
• CPC Class Codes: C07C 205/37 the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
• CPC Class Codes: C07C 217/80 having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
• CPC Class Codes: C07C 217/84 the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
• CPC Class Codes: C07C 255/43 the carbon skeleton being further substituted by singly-bound oxygen atoms

Abstract

A stilbene derivative of the following general formula (I) or a pharmaceutically acceptable acid addition salt thereof have low toxicity, but are water soluble and effective as carcinostatics: ##STR1## wherein R¹, R² and R³, which may be the same or different, each represent an alkyl group having 1 to 3 carbon atoms; X represents a hydrogen atom or a nitrile group; Y represents an alkyloxy group having 1 to 3 carbon atoms, an alkyl group having 1 to 6 carbon atoms or a halogen atom.

Claims

1. A stilbene derivative of general formula (I) or a pharmaceutically acceptable acid addition salt thereof:

##STR16## wherein R¹, R² and R³, which may be the same or different, each represent an alkyl group having 1 to 3 carbon atoms;

X represents a hydrogen atom or a nitrile group;

Y represents an alkyloxy group having 1 to 3 carbon atoms or an alkyl group having 1 to 6 carbon atoms.

2. The stilbene derivative or pharmaceutically acceptable acid addition salt thereof according to claim 1 wherein R¹, R² and R³ are each a methyl group.

3. The stilbene derivative or pharmaceutically acceptable acid addition salt thereof according to claim 1, wherein Y is a methoxy group.

4. The stilbene derivative or pharmaceutically acceptable acid addition salt thereof according to claim 1 having the formula ##STR17## or a pharmaceutically acceptable acid addition salt thereof.

5. The stilbene derivative or pharmaceutically acceptable acid addition salt thereof according to claim 1 having the formula ##STR18## or a pharmaceutically acceptable acid addition salt thereof.

6. A pharmaceutical composition comprising a carcinostatically effective amount of a stilbene derivative or a pharmaceutically acceptable acid addition salt thereof according to claim 1 and a pharmaceutically acceptable excipient, diluent or carrier.