Pressure-activated medication transfer system

• US 5,526,853 A
• Filed: 08/17/1994
• Issued: 06/18/1996
• Est. Priority Date: 08/17/1994
• Status: Expired due to Term

• Current Assignee: B Braun Medical Incorporated (B. Braun Holding GmbH & Co. KG)
• Original Assignee: McGaw, Inc. (B. Braun Holding GmbH & Co. KG)
• Inventors: Sacca, Giuseppe, Lovejoy, C. Kenneth, McPhee, Charles J.
• Primary Examiner(s): JACYNA, J CASIMER
• Application Number:
  US08/292,232
• Time in Patent Office: 671 Days
• Field of Search: 141/21-28, 141/319, 141/320, 141/329, 141/330, 141/114, 141/383, 141/386, 604/408, 604/41-416, 53/489
• US Class Current: 141/329
• CPC Class Codes: A61J 1/10 Bag-type containers
• CPC Class Codes: A61J 1/1475 Inlet or outlet ports
• CPC Class Codes: A61J 1/201 having one piercing end
• CPC Class Codes: A61J 1/2013 having two piercing ends
• CPC Class Codes: A61J 1/2089 Containers or vials which are to be joined to each other in order to mix their contents combinations of vial and syringe for mixing their contents A61J1/2096
• CPC Class Codes: A61J 2200/10 Coring prevention means, e.g. for plug or septum piecing members

Abstract

A binary connector intercouples a plugged drug vial and a plugged, flexible-walled diluent container so that the diluent can pass to the vial from the container only after the latter has been pressurized by squeezing. Sharp-tipped, hollow spikes with intercommunicating axial bores extend in diametrically opposite directions from a disk-shaped base, with jaws having circularly arrayed flexible arms extending in diametrically opposite directions from the base, coaxially around respective ones of the spikes. A compressible rubber plug is wedged in one of the bores. A vial is engaged to a container for liquid communication by snapping the connectors'"'"' jaws around their respective inlets, causing the connectors'"'"' hollow spikes to pierce their respective plugs. However, not until the container is squeezed is the plug expelled from the blocked bore and communication established between vial and container.

Claims

1. A connector for effecting pressurized communication between a pressurizable diluent container and a drug vial through respective openings sealed by respective penetrable stopper means, comprising:

(a) a base;

(b) a drug spike extending from said base in a first direction and having an axially extending drug bore open at its distal end;

(c) a diluent spike extending from said base in a second direction opposite said first direction and coaxially with said drug spike, said diluent spike having an axially extending diluent bore open near its distal end and communicating at its proximal end with the proximal end of said drug bore through said base;

(d) means for sealingly fastening said base against the respective openings of said drug vial and said diluent container when said drug spike and said diluent spike are thrust through the respective penetrable stopper means of said vial and said container; and

(e) a plug seated in and sealing one of said bores, said plug being disposed completely within said bore and being expellable from said sealed bore when said diluent container is pressurized.

2. The connector of claim 1, wherein the sealed one of said bores is tapered toward the distal end of said diluent spike, and said plug is compressible and is wedged in place in said tapered bore.

3. The connector of claim 2, wherein said tapered bore is the drug bore.

4. The connector of claim 2, wherein the tapered bore is dimensioned relative to said plug to cause said plug to be wedged in place within the sealed one of said bores.

5. The connector of claim 4, wherein said plug is cylindrical, has at least one annular sealing ring integral therewith, and has a cross-sectional size at its sealing ring that is less than the cross-sectional size of a first end of said tapered bore at one of its ends and greater than the cross-sectional size of the bore at its opposite end.

6. The connector of claim 1, wherein said drug bore and said diluent bore merge into each other to form a single composite bore having a continuous taper extending through both said drug spike and said diluent spike.

7. The connector of claim 6, wherein said tapered bore is dimensioned relative to said plug to cause said plug to become wedged in place in the diluent bore portion of said composite bore when forced therein.

8. The connector of claim 7, wherein said tapered bore is dimensioned relative to said plug to cause said plug to be wedged in place within said diluent bore.

9. The connector of claim 8, wherein said plug is cylindrical, has at least one annular sealing ring integral therewith, and has a cross-sectional size at its sealing ring that is less than the cross-sectional size of a first end of said tapered bore at one of its ends and greater than the cross-sectional size of the bore at its opposite end.

10. The connector of claim 9, wherein said plug is so configured and constituted that, when immersed in water, it sinks.

11. The connector of claim 10, wherein said plug is solid butyl rubber, coated with an anti-stick compound.

12. The connector of claim 1, wherein said container and said vial each includes an annular flange around its respective opening, and wherein said means for sealingly fastening said bore includes a resilient diluent jaw and a resilient drug jaw, each jaw comprising a set of teeth surrounding a respective one of said diluent and drug spikes for engaging a respective one of said container and vial flanges.

13. The connector of claim 12, wherein said drug jaw is integral with said base, and said diluent jaw is separate from but permanently attachable to said base.

14. The connector of claim 13, wherein said base includes a peripheral flange, and said diluent jaw includes a cap with a radially extending web terminating in a peripheral rim having radially inwardly sloping resilient ramps, said rim being sized to receive said peripheral flange when pressed into place past said resilient ramps.

15. The connector of claim 14, wherein the diluent jaw additionally incorporates a cylindrical skirt which extends axially away from the radially extending web, the skirt comprising a pair of opposed slots for accommodating the top portion of the diluent container when the diluent spike is in the container.

16. The connector of claim 14, wherein said diluent jaw comprises a set of resilient arms extending from said cap substantially parallel to said diluent spike along a perimeter which is coaxial therewith.

17. The connector of claim 16, wherein said diluent jaw comprises a first set of arms evenly distributed about said cap perimeter, each arm terminating in a short tooth extending radially inward and axially toward said cap, and a second set of arms alternating with said first set of arms around said cap perimeter, each of said second set of arms having a long tooth extending radially inward and axially toward said cap farther than said short teeth.

18. The connector of claim 1, wherein said container has flexible walls, whereby said container may be pressurized by squeezing.