Intradermal drug delivery device and method for intradermal delivery of drugs
First Claim
1. An intradermal drug delivery device for delivering a liquid drug to a subject via the subject'"'"'s skin, comprising:
- (a) a housing having a lower surface for application to the skin of the subject;
(b) means for affixing the housing in position with the lower surface in contact with the subject'"'"'s skin;
(c) a drug reservoir within the housing, wherein the reservoir is in the form of an expansible-contractible chamber which is expanded when filled with the drug and which can be contracted to dispense the drug therefrom;
(d) a single hollow needle associated with the drug reservoir extending through the lower surface, having an inner end communicating with the drug reservoir and an outer end projecting outwards a sufficient distance so as to penetrate through the epidermis and into the dermis when the housing is pressed against the skin; and
(e) means for actively discharging the drug from the reservoir to the subject'"'"'s skin via the needle;
wherein the lower surface is shaped such that when it is pressed against the skin a substantial proportion of the pressure applied to the skin is directed through the needle tip.
10 Assignments
0 Petitions
Accused Products
Abstract
An intradermal drug delivery device for delivering a liquid drug to a subject via the subject'"'"'s skin includes a housing having a lower surface provided with an adhesive coating for adhering the housing to the subject'"'"'s skin. An expansible-contractible chamber within the housing defines a reservoir which is expanded upon being filled with the drug and contracted to dispense the drug. A hollow needle extends through the lower surface of the housing and has an inner end which communicates with the reservoir and an outer end which projects outwardly of the housing a short distance to penetrate through the epidermis and into the dermis of the subject'"'"'s skin when the housing is adhered thereto. The device permits delivery of drugs of relatively large molecular size and at slow rates which can be precisely controlled. A method of delivering a liquid drug intradermally includes adhering the intradermal delivery device to the skin of the subject and activating the means for actively discharging the at least one drug from the reservoir to the subject'"'"'s skin via the needle.
-
Citations
37 Claims
-
1. An intradermal drug delivery device for delivering a liquid drug to a subject via the subject'"'"'s skin, comprising:
-
(a) a housing having a lower surface for application to the skin of the subject; (b) means for affixing the housing in position with the lower surface in contact with the subject'"'"'s skin; (c) a drug reservoir within the housing, wherein the reservoir is in the form of an expansible-contractible chamber which is expanded when filled with the drug and which can be contracted to dispense the drug therefrom; (d) a single hollow needle associated with the drug reservoir extending through the lower surface, having an inner end communicating with the drug reservoir and an outer end projecting outwards a sufficient distance so as to penetrate through the epidermis and into the dermis when the housing is pressed against the skin; and (e) means for actively discharging the drug from the reservoir to the subject'"'"'s skin via the needle; wherein the lower surface is shaped such that when it is pressed against the skin a substantial proportion of the pressure applied to the skin is directed through the needle tip. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
-
-
32. An intradermal drug delivery device for delivering a liquid drug to a subject via the subject'"'"'s skin, comprising:
-
(a) a housing having a lower surface for application to the skin of the subject; (b) means for affixing the housing in position with the lower surface in contact with the subject'"'"'s skin; (c) a drug reservoir within the housing; (d) a single hollow needle associated with the drug reservoir extending through the lower surface, having an inner end communicating with the drug reservoir and an outer end projecting outwards a sufficient distance so as to penetrate through the epidermis and into the dermis when the housing is pressed against the skin; and (e) means for actively discharging the drug from the reservoir to the subject'"'"'s skin via the needle, wherein the means for actively discharging the drug comprises an electrically controlled gas generator within the housing for generating a gas to contract the drug reservoir in order to discharge the drug therefrom; wherein the lower surface is shaped such that when it Is pressed against the skin a substantial proportion of the pressure applied to the skin is directed through the needle tip. - View Dependent Claims (33, 34, 35, 36)
-
-
37. An intradermal drug delivery device for delivering a liquid drug to a subject via the subject'"'"'s skin, comprising:
-
(a) a housing having a lower surface for application to the skin of the subject; (b) means for affixing the housing in position with the lower surface in contact with the subject'"'"'s skin; (c) a drug reservoir within the housing; (d) a single hollow needle associated with the drug reservoir extending through the lower surface, having an inner end communicating with the drug reservoir and an outer end projecting outwards a sufficient distance so as to penetrate through the epidermis and into the dermis when the housing is pressed against the skin; and (e) means for actively discharging the drug from the reservoir to the subject'"'"'s skin via the needle; wherein the lower surface is shaped such that when it is pressed against the skin a substantial proportion of the pressure applied to the skin is directed through the needle tip and wherein the lower surface of the housing is provided with a protuberance from which the needle projects.
-
Specification