Pharmacologic atrial defibrillator and method

• US 5,527,344 A
• Filed: 08/01/1994
• Issued: 06/18/1996
• Est. Priority Date: 08/01/1994
• Status: Expired due to Fees

• Current Assignee: Illinois Institute of Technology
• Original Assignee: Illinois Institute of Technology
• Inventors: Bloem, David R., Bump, Thomas E., Yurkonis, Charles E., Arzbaecher, Robert C.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): Getzow, Scott M.
• Application Number:
  US08/283,406
• Time in Patent Office: 687 Days
• Field of Search: 607/3, 607/4, 607/5, 604/20
• US Class Current: 607/3
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61N 1/395 for treating atrial fibrillation

Abstract

A method and an implantable apparatus for automatically delivering a defibrillating drug to a patient upon detection of the onset of atrial fibrillation. Atrial activity of a heart is detected and monitored. A delivery time is continuously computed and a delivery signal is emitted as a function of the monitored level of the atrial activity. When the delivery signal is emitted, an infusion pump discharges a defibrillating drug into the bloodstream of the patient. The atrial activity is also continuously monitored for computing a pacing time at which a pacing signal is emitted as a second function of the monitored level of atrial activity. When the pacing signal is emitted a pacer paces the atrium of the heart.

Claims

1. A method for delivering upon demand a defibrillating drug to a patient, the method comprising the steps of:

(a) detecting and monitoring a level of atrial activity and a level of ventricular activity of a heart of the patient;

(b) continuously computing a delivery time to emit a delivery signal as a first function of the monitored level of atrial activity;

(c) emitting the delivery signal at the computed delivery time to delivery means for introducing the defibrillating drug into a bloodstream of the patient;

(d) continuously computing a pacing time to emit a pacing signal as a second function of the monitored level of atrial activity and ventricular activity; and

(e) emitting the pacing signal at the computed pacing time to pacing means for pacing an atria of the heart.

2. A method for delivering upon demand a defibrillating drug to a patient, the method comprising the steps of:

(a) detecting and monitoring a level of atrial activity of a heart of the patient by estimating an atrial rate using a median value of an interval between atrial activations;

(b) continuously computing a delivery time to emit a delivery signal as a first function of the monitored level of atrial activity;

(c) emitting the delivery signal at the computed delivery time to delivery means for introducing the defibrillating drug into a bloodstream of the patient;

(d) continuously computing pacing time to emit a pacing signal as a second function of the monitored level of atrial activity; and

(e) emitting the pacing signal at the computed pacing time to pacing means for pacing an atria of the heart.

3. A method for delivering upon demand a defibrillating drug to a patient, the method comprising the steps of:

(a) detecting and monitoring a level of atrial activity of a heart of the patient;

(b) continuously computing a delivery time to emit a delivery signal by computing a median value of a plurality of sensed time intervals each occurring between two atrial senses, comparing the median value to a threshold value, and emitting the delivery signal when the median value is less than a threshold value;

(c) emitting the delivery signal at the computed delivery time to delivery means for introducing the defibrillating drug into a bloodstream of the patient;

(d) continuously computing pacing time to emit a pacing signal as a second function of the monitored level of atrial activity; and

(e) emitting the pacing signal at the computed pacing time to pacing means for pacing an atria of the heart.

4. A method according to claim 3 wherein the threshold value is approximately 200 milliseconds.

5. A method for delivering upon demand a defibrillating drug to a patient, the method comprising the steps of:

(a) detecting and monitoring a level of atrial activity of a heart of the patient;

(b) continuously computing a delivery time to emit a delivery signal by establishing a first threshold value of an interval between successive atrial sensings, reducing the first threshold value and establishing a second threshold value, comparing a first interval corresponding to the first threshold value to a second interval established by the second threshold value, and emitting the delivery signal upon detection of the second interval being less than the first interval by a predetermined amount;

(c) emitting the delivery signal at the computed delivery time to delivery means for introducing the defibrillating drug into a bloodstream of the patient;

(d) continuously computing a pacing time to emit a pacing signal as a second function of the monitored level of atrial activity; and

(e) emitting the pacing signal at the computed pacing time to pacing means for pacing an atria of the heart.

6. A method for delivering upon demand a defibrillating drug to a patient, the method comprising the steps of:

(a) detecting and monitoring a level of atrial activity of a heart of the patient;

(b) continuously computing a delivery time to emit a delivery signal by calculating a concentration of the defibrillating drug in the bloodstream, and pulsing the delivery means to introduce the defibrillating drug into the bloodstream when the concentration is below a predetermined value;

(c) emitting the delivering signal at the computed delivery time to delivery means for introducing the defibrillating drug into the bloodstream of the patient;

(d) continuously computing a pacing time to emit a pacing signal as a second function of the monitored level of atrial activity; and

(e) emitting the pacing signal at the computed pacing time to pacing means for pacing an atria of the heart.

7. A method according to claim 6 wherein the concentration is calculated with a two-compartment pharmacokinetics equation using a blood concentration value C1 and a peripheral compartment concentration value C2.

8. A method according to claim 6 wherein the delivery means introduces the defibrillating drug into the bloodstream in pulsed amounts.

9. An implantable apparatus for automatically delivering upon demand a defibrillating drug to a patient, the apparatus comprising:

sensor means for sensing and monitoring a level of atrial activity of a heart of a patient;

first computer means for computing a delivery time and emitting a delivery signal as a function of said monitored level of atrial activity;

delivery means for introducing the defibrillating drug into a bloodstream of the patient at said delivery time;

second computer means for continuously computing a pacing time and emitting a pacing signal as a second function of said monitored level of atrial activity;

pace means for receiving said pacing signal and pacing an atria of said heart at said pacing time;

at least one hermetically sealed enclosure; and

said first computer means, said second computer means, said delivery means and said pacing means housed within said at least one hermetically sealed enclosure.

10. An apparatus according to claim 9 wherein said sensor means comprise a lead having one end adapted for contacting an endocardium of said heart and an opposite end in communication with at least one of said first computer means and said second computer means.

11. An apparatus according to claim 10 wherein said lead is an endocardial lead, said one end of said endocardial lead comprising two electrodes each adapted for contacting an interior surface of a right atrium of said heart.

12. An apparatus according to claim 10 wherein said first computer means comprise an amplification means for amplifying an atrial signal communicated through said lead.

13. An apparatus according to claim 9 wherein said first computer means comprise atrial defibrillation means for detecting an onset of atrial fibrillation as a function of a sensed and amplified signal received from said sensor means.

14. An apparatus according to claim 13 wherein said first computer means comprise an infusion controller in communication with said atrial defibrillation means, and said infusion controller computing and emitting said delivery signal to said delivery means at said delivery time.

15. An apparatus according to claim 9 wherein said delivery means comprise an infusion pump having an inlet in fluid communication with a reservoir containing a defibrillating drug and an outlet adapted for fluid communication with said bloodstream.

16. An apparatus according to claim 15 wherein said delivery means further comprise a solenoid valve forming fluid communication between said inlet and said outlet upon receipt of said delivery signal.

17. An apparatus according to claim 9 wherein said delivery means comprise a defibrillating drug reservoir, a catheter having one end in communication with said defibrillating drug reservoir and an opposite end adapted for communication with said bloodstream.

18. An apparatus according to claim 9 wherein said second computer means comprise a pulse generator, a pacing controller emitting said pacing signal to said pulse generator as a function of a sensed and amplified signal received from said sensor means.

19. An apparatus according to claim 18 further comprising a lead having one end adapted for contacting an endocardium of said heart, and said pulse generator delivering an output voltage through said lead.