Dual chamber pacing system and method with automatic adjustment of the AV escape interval for treating cardiomyopathy

• US 5,527,347 A
• Filed: 02/21/1995
• Issued: 06/18/1996
• Est. Priority Date: 02/21/1995
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Warkentin, Dwight H., Shelton, Michael B.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): SCHAETZLE, KENNEDY
• Application Number:
  US08/391,884
• Time in Patent Office: 483 Days
• Field of Search: 607/9, 607/28, 607/17, 607/25
• US Class Current: 607/9
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay

Abstract

There is provided a dual chamber pacemaker system and method for ventricular pacing to provide therapy for a patient with cardiomyopathy, this system being characterized by automatically adjusting the AV escape interval so that ventricular pace pulses are delivered at an AV delay which is optimized for HOCM and/or dialated cardiomyopathy therapy. The pacemaker system continually obtains and stores representations of a QRS wave characteristic such as duration, derived either directly from the QRS signal or from an FFRS signal, and compares duration data from one or more cycles to prior stored duration data. The system then adjusts the AV interval as a function of the duration comparison, and the direction of the last adjustment of AV escape interval. By this means, the AV escape interval is maintained at or just short of the onset of fusion, thereby automatically providing for optimally lengthened AV escape intervals consistent with full capture by the delivered ventricular pace pulse.

Claims

1. A dual chamber pacemaker system, having atrial sense means for sensing signals from a patient'"'"'s atrium, ventricular sense means for sensing ventricular signals from a patient, ventricular pace means for generating and delivering ventricular pace pulses to said patient'"'"'s right ventricle, AV_esc means for setting and timing out an AV escape interval from the occurrence of the sensed atrial depolarization, and sync control means for controlling delivery of a ventricular pace pulse at the time out of a said AV escape interval in the absence of a sensed ventricular signal, comprising

wave means for obtaining and storing representations of QRS waves that have been evoked by delivered ventricular pace pulses,

controllable adjust means for adjusting said AV_esc means to vary said AV escape interval in a controlled direction, and storage means for storing a representation of said direction,

change means for detecting a change of successive such QRS representations, and

control means for controlling said adjust means as a function of said detected change and said stored direction.

2. The pacemaker system as described in claim 1, wherein said obtaining means comprises means for cyclically obtaining a representation of the duration of the QRS wave, and said change means has means for comparing each QRS representation with the QRS representation of the prior cycle.

3. The pacemaker system as described in claim 1, wherein said change means comprises means for determining when said representation changes from the prior representation by more than a predetermined amount.

4. The pacemaker system as described in claim 1, wherein control means has means for controlling said adjust means to decrement AV escape interval by a first factor when said stored direction is to shorten AV escape interval, and by a second factor when said stored direction is to increment AV escape interval.

5. The pacemaker system as described in claim 4, wherein said first factor is greater than said second factor.

6. The pacemaker system as described in claim 1, wherein said representation is QRS duration, the variation of QRS duration with AV escape interval having a range of variation defining a fusion range, and wherein said control means controls said adjust means to adjust said AV escape interval toward maintaining AV escape interval at a value within the lower portion of said fusion range.

7. The pacemaker system as described in claim 1, further comprising means for detecting when there has been no substantial change of said representation from one cycle to the next, and wherein said control means generally maintains said AV escape interval constant when there has been no substantial change.

8. The pacemaker system as described in claim 7, further comprising determining means for determining when there has been no substantial change in said QRS representation over a predetermined plurality of pacemaker cycles, and second change means for incrementing said AV escape interval in response to a said determination.

9. The pacemaker system as described in claim 1, comprising FFRS means for detecting FFRS signals, and wherein said wave means comprises means for obtaining said QRS representations from said detected FFRS signals.

10. A method of dual chamber cardiac 5pacing for heart pacing therapy, comprising sensing the occurrence of natural atrial beats, initiating timeout of an AV escape interval following a sensed atrial beat and delivering a ventricular pace pulse at the timeout of a said AV escape interval in the absence of a sensed ventricular natural beat, and controlling said AV escape interval in a direction to maximize the number of delivered ventricular pace pulses that evoke complete capture of the heart and to maximize the AV escape interval, said method including:

obtaining a measure of the duration of each evoked QRS, and storing said measure,

comparing the measure of each QRS duration with the stored value of the prior QRS duration and determining when said compared values differ by more than a predetermined amount, and

adjusting said AV escape interval in a determined lengthening or shortening direction as a function of said comparison.

11. The method as described in claim 10, comprising storing said determined direction, and wherein said adjusting step further comprises determining said direction as a function of the stored direction from the prior pacemaker cycle.

12. The method as described in claim 11, wherein said adjusting step comprises decrementing AV escape interval by a first predetermined amount when QRS duration has decreased following a prior increase in AV escape interval.

13. The method as described in claim 12, wherein said adjusting step comprises incrementing AV escape interval by a second predetermined amount when QRS duration has decreased following a prior decrement of AV escape interval.

14. The method as described in claim 13, wherein said first amount is greater than said second amount.

15. A method of dual chamber pacing for cardiomyopathy therapy, comprising:

cyclically collecting QRS characteristic data;

determining and storing the differences of said data for respective pairs of successive cycles;

adjusting AV escape interval as a function of said differences and storing the direction of each adjustment, and said adjusting step including determining the direction of the adjustment as a function of the direction of the last such adjustment.

16. A dual chamber pacemaker having atrial sense means for sensing signals in a patient'"'"'s atrium, ventricular sense means for sensing signals in said patient'"'"'s ventricle, ventricular pace means for generating and delivering ventricular pace pulses to the patient'"'"'s ventricle, and AV control means for controlling said pace means to generate and deliver a ventricular pace pulse at a controlled AV escape interval following a sensed atrial signal, comprising:

means for continually monitoring a measure of the duration of the QRS signal sensed by either said atrial sense means or said ventricular sense means,

first determining means for continually determining whenever said duration measure is shorter than a prior duration measure, and adjustment means for decrementing said AV escape interval by a first value in response to a determination by said determining means; and

second determining means for determining when said duration measure has been substantially constant for a predetermined time, and wherein said adjustment means further comprises increment means for incrementing said AV escape interval by a second value in response a said substantially constant determination.

17. The pacemaker as described in claim 16, wherein said first interval is greater than said second interval.

18. The pacemaker as described in claim 16, wherein said first determining means is operative each pacemaker cycle.

19. The pacemaker as described in claim 16, wherein said second determining means has periodic means for making said determination periodically.

20. The pacemaker as described in claim 19, wherein said periodic means makes said determination every n cycles.