Photochemotherapy dosimeter

• US 5,527,349 A
• Filed: 06/05/1995
• Issued: 06/18/1996
• Est. Priority Date: 01/25/1994
• Status: Expired due to Term

• Current Assignee: United States Department Of Health And Human Services, United States Incorporated
• Original Assignee: United States Department Of Health And Human Services
• Inventors: Matchette, Stephanie, Landry, Robert J., Merberg, Glenn N.
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): NASSER, ROBERT L
• Application Number:
  US08/463,665
• Time in Patent Office: 379 Days
• Field of Search: 609/86-94, 128/633-4, 128/664-6, 250/370.07
• US Class Current: 607/88
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent
• CPC Class Codes: G01J 1/50 using change in colour of an indicator, e.g. actinometer

Abstract

A photochemotherapy dosimeter for monitoring cumulative photochemotherapy radiation dosage. The photochemotherapy dosimeter includes an optical fiber having a chemical cell attached at one end thereof. The chemical cell contains a photobleachable chemical which can be in a solution or incorporated into a matrix material. Changes in the absorption of the photobleachable chemical are used to monitor the cumulative photochemotherapy radiation dosage. In use, the chemical cell of the photochemotherapy dosimeter is positioned near an abnormal tissue which is subjected to photochemotherapy treatment.

Claims

1. A method of monitoring photochemotherapy during treatment of abnormal tissue which comprises:

directing photochemotherapy radiation to an abnormal tissue;

providing at least one photochemotherapy dosimeter having an optical fiber and a chemical cell attached to an end of said optical fiber which chemical cell contains a photobleachable chemical;

positioning said at least one photochemotherapy dosimeter near said abnormal tissue so that said chemical cell of said at least one photochemotherapy dosimeter receives said photochemotherapy radiation; and

detecting changes in optical radiation absorption of said photobleachable chemical in said chemical cell.

2. A method of monitoring photochemotherapy during treatment of abnormal tissue according to claim 1, wherein said photochemotherapy radiation directed to said abnormal tissue is controlled in response to said detected changes in optical radiation absorption of said photobleachable chemical in said chemical cell.

3. A method of monitoring photochemotherapy during treatment of abnormal tissue according to claim 1, wherein said optical radiation absorption is detected from an optical interrogator pulse which passes through said photochemotherapy dosimeter.

4. A method of monitoring photochemotherapy during treatment of abnormal tissue according to claim 1, wherein said abnormal tissue comprises a non-superficial tumor.