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Anti-CD3 antibody-aminodextran conjugates for induction of T-cell activation and proliferation

  • US 5,527,713 A
  • Filed: 07/19/1995
  • Issued: 06/18/1996
  • Est. Priority Date: 06/11/1993
  • Status: Expired due to Term
First Claim
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1. An antibody-aminodextran conjugate for induction of T-cell activation and proliferation, consisting essentially of T-cell specific antibodies covalently bound to amine groups present on a water soluble aminodextran having about 7-20% by weight amine groups and a molecular weight of at least 100,000 daltons, wherein said antibodies are of a single type each specific for the same T-cell antigen and wherein the molar ratio of said antibodies to said aminodextran is greater than or equal to two.

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