Anti-CD3 antibody-aminodextran conjugates for induction of T-cell activation and proliferation
First Claim
1. An antibody-aminodextran conjugate for induction of T-cell activation and proliferation, consisting essentially of T-cell specific antibodies covalently bound to amine groups present on a water soluble aminodextran having about 7-20% by weight amine groups and a molecular weight of at least 100,000 daltons, wherein said antibodies are of a single type each specific for the same T-cell antigen and wherein the molar ratio of said antibodies to said aminodextran is greater than or equal to two.
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Abstract
The invention describes the use of novel aminodextran compounds containing about 5-20% by weight amine groups to bind a plurality of monoclonal antibodies. The resulting antibody-aminodextran compounds may be used to induce the activation and proliferation of selected mammalian cells. Specific examples are given using an anti-CD3 monoclonal antibody conjugated two aminodextrans containing about 5% and 16%, respectively, by weight amine groups as an agent for inducing the activation and proliferation of T cells.
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Citations
9 Claims
- 1. An antibody-aminodextran conjugate for induction of T-cell activation and proliferation, consisting essentially of T-cell specific antibodies covalently bound to amine groups present on a water soluble aminodextran having about 7-20% by weight amine groups and a molecular weight of at least 100,000 daltons, wherein said antibodies are of a single type each specific for the same T-cell antigen and wherein the molar ratio of said antibodies to said aminodextran is greater than or equal to two.
- 5. An antibody-aminodextran conjugate for induction of T-cell activation and proliferation, consisting essentially of T-cell specific monoclonal antibodies and a water soluble aminodextran having a molecular weight of at least 100,000 daltons and about 7-20% by weight amine groups to which said antibodies are conjugated, wherein said antibodies are of a single type each specific for the same T-cell antigen and wherein the molar ratio of said antibodies to said aminodextran is greater than or equal to two.
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