Method for measuring scattering medium and apparatus for the same

• US 5,529,065 A
• Filed: 06/01/1994
• Issued: 06/25/1996
• Est. Priority Date: 06/02/1993
• Status: Expired due to Term

• Current Assignee: Hamamatsu Photonics KK
• Original Assignee: Hamamatsu Photonics KK
• Inventors: Tsuchiya, Yutaka
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US08/251,969
• Time in Patent Office: 755 Days
• Field of Search: 128/633, 128/664, 128/665
• US Class Current: 600/310
• CPC Class Codes: A61B 2562/0242 for varying or adjusting the optical path length in the tissue
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/7242 using integration
• CPC Class Codes: G01N 21/49 within a body or fluid

Abstract

A method of measuring internal information in a scattering medium and an apparatus for the same of the present invention measure internal information in the scattering medium by measuring light diffused during propagation in the scattering medium at outside of the scattering medium while receiving the influence of the scattering and absorption, and performing arithmetic processing to the measured values. At this time, the three or more kinds of the detected signals (measured values) detected at a plurality of distances between the light incident position and the photodetection point for the light having a plurality of predetermined wavelengths are processed by utilizing dependencies of the behavior of light diffused during propagation in the scattering medium and the resulting signal, i.e., a photodetection signal on characteristics such as a scattering constituent, or an absorption constituent in the scattering medium and their concentration. If the measurement is performed at a plurality of wavelenghts on an object to be measured, a ratio of absorption coefficients and a ratio of concentrations of specified absorptive constituents in scattering medium can be measured.

Claims

1. A method of measuring a scattering medium comprising:

emitting light having a plurality of predetermined wavelengths, λ

_j, said wavelengths having transport scattering coefficients, μ

_S '"'"', in the scattering medium that are almost equal to each other;

causing said light to be incident on the scattering medium at a light incidence position to propagate said light through the scattering medium;

detecting said light which has propagated through the scattering medium at at least two photodetection points, with distances ρ

_i, between the light incidence position and each of the photodetection points being different from each other, to obtain at least three detected signals; and

extracting internal information of the scattering medium with respect to each of said wavelengths of said light, by converting said at least three detected signals to at least three measured values, I(ρ

_i, λ

_j), and then performing arithmetic processing to said at least three measured values, I(ρ

_i, λ

_j), based on a simultaneous relation of the following equation;

##EQU7## where I(ρ

_i, λ

_j) represents each of the measured values,

i is an integer running from one to an integer greater than one,

j is an integer running from one to an integer greater than one,

μ

_effj represents an effective attenuation coefficient for light having wavelength λ

_j

space="preserve" listing-type="equation">μ

.sub.effj =(3μ

.sub.aj (μ

.sub.aj +μ

.sub.S '"'"')).sup.1/2,

where

μ

_aj is an absorption coefficient for light having wavelength λ

_j,

μ

_S '"'"' is the transport scattering coefficient, and

z₀ =1/μ

_s '"'"'.

2. A method of measuring a scattering medium according to claim 1, wherein said extracting step includes selecting internal information from the group consisting of the effective attenuation coefficients, μ

_effj, and a ratio of the absorption coefficients, μ

_aj.

3. A method of measuring a scattering medium according to claim 1, wherein said light having the plurality of predetermined wavelengths, λ

_j, of which the absorption coefficients, μ

_aj, to specified absorptive constituents in said scattering medium are different from each other, said method further comprising the step of;

calculating further internal information with respect to said specified absorptive constituents in said scattering medium by use of the internal information obtained in said extracting step.

4. A method of measuring a scattering medium according to claim 3, wherein said extracting step includes extracting internal information including a ratio of the absorption coefficients, μ

_aj, with respect to the wavelengths of said light, and a ratio of concentrations of the specified absorptive constituents in the scattering medium.

5. A method of measuring a scattering medium according to claim 1, wherein said three or more detected signals are each detected for a period of time and integrated over said period of time to calculate said three or more measured values, I(ρ

_i λ

_j).

6. An apparatus for measuring a scattering medium comprising:

light-emitting means for emitting light having a plurality of predetermined wavelengths, λ

_j, said wavelength having transport scattering coefficients, μ

_S '"'"', in the scattering medium that are almost equal to each other;

light-incident means for causing said light to be incident on the scattering medium at a light incidence position to propagate said light through the scattering medium;

photodetecting means for detecting said light which has been propagated through the scattering medium at at least two photodetection points, with distances, ρ

_i, between the light incidence position and each of the photodetection points being different form each other, to obtain at least three detected signals; and

first arithmetic processing means for extracting internal information of the scattering medium with respect to each of said wavelengths of said light, by converting said at least three detected signals to at least three measured values, I(ρ

_i, λ

_j), and then performing arithmetic processing to said at least three measured values, I(ρ

_i, λ

_j), based on a simultaneous relation of the following equation;

space="preserve" listing-type="equation">ln(I(ρ

.sub.i,λ

.sub.j))=ln(z.sub.0 /(2π

))-3/2ln(z.sub.0.sup.2 +ρ

.sub.i.sup.2)+ln(μ

.sub.effj (z.sub.0.sup.2 +ρ

.sub.i.sup.2).sup.1/2 +1)-μ

.sub.effj (z.sub.0.sup.2 +ρ

.sub.i.sup.2).sup.1/2

where

I(ρ

_i, λ

_j) represents each of the measured values,

i is an integer running from one to an integer greater than one,

j is an integer running from one to an integer greater than one,

μ

_effj represents an effective attenuation coefficient for light having wavelength λ

_i

space="preserve" listing-type="equation">μ

.sub.effj =(3μ

.sub.aj (μ

.sub.aj +μ

.sub.S '"'"')).sup.1/2,

where

μ

_aj designates an absorption coefficient for light having wavelength λ

_j,

μ

_S '"'"' is the transport scattering coefficient, and

z₀ =1/μ

_S '"'"'.

7. An apparatus for measuring a scattering medium according to claim 6, wherein said internal information is selected from the group consisting of the effective attenuation coefficients, μ

_effj, and a ratio of the absorption coefficients, μ

_aj.

8. An apparatus for measuring a scattering medium according to claim 6, wherein said light having the plurality of predetermined wavelengths, λ

_j, of which the absorption coefficients, μ

_aj, to specified absorptive constituents in said scattering medium are different from each other, said apparatus further comprising;

second arithmetic processing means for calculating further internal information with respect to said specified absorptive constituents in said scattering medium by use of the internal information obtained in said first arithmetic processing means.

9. An apparatus for measuring a scattering medium according to claim 8, wherein said internal information obtained in said second arithmetic processing means includes a ratio of absorption coefficients, μ

_aj, with respect to the wavelengths of the said light, and a ratio of concentrations of the specified absorptive constituents in the scattering medium.

10. An apparatus for measuring a scattering medium according to claim 6, wherein said at least three detected signals are each detected for a period of time and integrated over said period of time to calculate said three or more measured values, I(ρ

_i, λ

_j).

11. An apparatus for measuring a scattering medium according to claim 6, wherein said light-incident means is a light guide.

12. An apparatus for measuring a scattering medium comprising:

light-emitting means for emitting light having a plurality of predetermined wavelengths, λ

_j, of which transport scattering coefficients, μ

_S '"'"', to the scattering medium are to be almost equal to each other;

light incident means for causing said light to be incident on the scattering medium at a light incidence position to propagate said light through the scattering medium;

photodetecting means for detecting said light which has been propagated through the scattering medium at a plurality of photodetection points, with distances, ρ

_i, between the light incidence position and each of the photodetection points being different from each other, to obtain at least three detected signals; and

arithmetic processing means for extracting internal information of the scattering medium with respect to each of said wavelength of said light used, by converting said at least three detected signals to at least three measured values, I(ρ

_i, λ

_j), and then performing arithmetic processing to said at least three measured values, I(ρ

_i, λ

_j), based on a simultaneous relation of the following equation;

space="preserve" listing-type="equation">ln(I(ρ

.sub.i,λ

.sub.j))=ln(z.sub.0 /(2π

))-3/2ln(z.sub.0.sup.2 +ρ

.sub.i.sup.2)+ln(μ

.sub.effj (z.sub.0.sup.2 +ρ

.sub.i.sup.2).sup.1/2 +1)-μ

.sub.effj (z.sub.0.sup.2 +ρ

.sub.i.sup.2).sup.1/2

where

I(ρ

_i, λ

_j) represents each of the measured values,

i is an integer running from one to an integer greater than two,

j is an integer running from one to an integer greater than two,

μ

_effj represents an effective attenuation coefficient for light having wavelength λ

_j

space="preserve" listing-type="equation">μ

.sub.effj =(3μ

.sub.aj (μ

.sub.aj +μ

.sub.S '"'"')).sup.1/2,

where

μ

_aj designates an absorption coefficient for light having wavelength λ

_j, and

z₀ =1/μ

_s '"'"',

wherein said at least three measured values, I(ρ

_i, λ

_j), comprise I(ρ

₁, λ

₁), I(ρ

₂, λ

₁), I(ρ

₁, λ

₂), and I(ρ

₂, λ

₂); and

the arithmetic processing means obtains a ratio of absorption coefficient, μ

_a1, μ

_a2 as said internal information based on the following equation;

##EQU8##

13. where ρ

₁. ρ

₂ are distances between the light incidence position and the photodetection points,

λ

₁, λ

₂ are wavelengths of the light used,

μ

_a1 is an absorption coefficient for light having wavelength λ

₁, and

μ

_a2 is an absorption coefficient for light having wavelength λ

₂.

14. A method of measuring a scattering medium comprising:

emitting light having a plurality of predetermined wavelengths, λ

_j, said wavelengths having transport scattering coefficients, μ

_s '"'"', in the scattering medium that are almost equal to each other;

causing said light to be incident on the scattering medium at a light incidence position to propagate said light through the scattering medium;

detecting said light which has propagated through the scattering medium at at least two photodetection points, with distances ρ

_i, between the light incidence position and each of the photodetection points being different from each other, to obtain at least three detected signals; and

extracting internal information of the scattering medium with respect to each of said wavelengths of said light, by converting said at least three detected signals to at least three measured values, I(ρ

_i, λ

_j), and then performing arithmetic processing to said at least three measured values, I(ρ

_i, λ

_j), based on a simultaneous relation of the following equation;

space="preserve" listing-type="equation">ln(I(ρ

.sub.i,λ

.sub.j))=ln(z.sub.o /(2π

))-3/2ln(z.sub.o.sup.2 +ρ

.sub.i.sup.2)+ln(μ

.sub.effj (z.sub.o.sup.2 +ρ

.sub.i.sup.2).sup.1/2 +1)-μ

.sub.effj (z.sub.o.sup.2 +ρ

.sub.i.sup.2).sup.1/2

where

I(ρ

_i, λ

_j) represents each of the measured values,

i is an integer running from one to an integer greater than one,

j is an integer running from one to an integer greater than one,

μ

_effj represents an effective attenuation coefficient for light having wavelength λ

_j

space="preserve" listing-type="equation">μ

.sub.effj =(3μ

.sub.aj (μ

.sub.aj +μ

.sub.s '"'"')).sup.1/2,

where

μ

_aj is an absorption coefficient for light having wavelength λ

_j,

μ

_S '"'"' is the transport scattering cofficient, and

z₀ =1/μ

_s '"'"'

wherein said at least three measured values, I(ρ

_i, λ

_j), comprises I(ρ

₁, λ

₁), I(ρ

₂, λ

₁), I(ρ

₁, λ

₂), and I(ρ

₂, λ

₂); and

a ratio of absorption coefficients, μ

_a1, μ

_a2 is obtained as said internal information in said extracting step based on the following equation;

##EQU9##

15. where ρ

₁. ρ

₂ are distances between the light incidence position and the photodetection points,

λ

₁, λ

₂ are wavelengths of the light used,

μ

_a1 is an absorption coefficient for light having wavelength λ

₁, and

μ

_a2 is an absorption coefficient for light having wavelength λ

₂.