System for detection of electrical bioimpedance signals

• US 5,529,072 A
• Filed: 07/05/1995
• Issued: 06/25/1996
• Est. Priority Date: 03/17/1995
• Status: Expired due to Term

• Current Assignee: Hemo Sapiens, Inc.
• Original Assignee: Bohumir Sramek
• Inventors: Sramek, Bohumir
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US08/498,477
• Time in Patent Office: 356 Days
• Field of Search: 128/691, 128/692, 128/693, 128/734
• US Class Current: 600/506
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/0535 Impedance plethysmography for measuring blood flow A61B5/0295
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives

Abstract

A system and method for detection of electrical bioimpedance signals in a human or animal body segment. The system comprises a constant current generator for generating a periodic high frequency current output across a body segment in response to a periodic control input signal, a controller for generating a periodic control output signal to control operation of the current generator and an electrical bioimpedance detector for detecting a voltage generated across the body segment by the flow of current in the segment. The electrical bioimpedance detector generates an output signal indicative of bioimpedance in the body segment. The periodic generation of a current across a body segment alleviates the potentially detrimental effects of a continuous current on body segment tissue and reduces interference with the function of certain pacemakers.

Claims

1. A system for determining or measuring fluid content or fluid flow in a human or animal body segment, comprising:

(a) a current generator means for generating a periodic high frequency current output in response to a periodic control signal, the current generator means comprising;

(i) a first and a second output terminal means for carrying the current output, wherein the first and the second output terminal means are adapted to be electrically connectable to a first and a second portion of the human or animal body segment, respectively; and

(ii) an input terminal means for receiving the control signal;

(b) a controller means for generating the periodic control signal to control operation of the current generator means, the controller means including an output terminal means for carrying the control signal, wherein the output terminal means of the controller means is electrically connected to the input terminal means of the current generator means; and

(c) an electrical bioimpedance detector means for detecting a voltage between the first and the second portion of the human or animal body segment caused by the current output of the current generator means flowing between the first and the second portion of the human or animal body segment, and for generating an output signal in response, wherein the output signal is indicative of impedance in the human or animal body segment between the first and the second portion, the bioimpedance detector comprising;

(i) a first and a second input terminal means for detecting said voltage, wherein the first and the second input terminal means of the bioimpedance detector means are adapted to be electrically connectable to the human or animal body segment proximate said first and second output terminal means of the current generator means, respectively;

(ii) a sensing circuit means, coupled to the input terminal means of the bioimpedance detector means, for receiving said voltage and generating an output signal having a magnitude that changes in accordance with the content or flow of fluids in the human or animal body segment between the first and second body segment portions;

(iii) a third input terminal electrically connected to the output terminal means of the controller means, whereby the control signal of the controller means is simultaneously received by both the current generator means and the bioimpedance detector means; and

(iv) a synchronizer means, coupled to the sensing circuit means, for controlling the operation of the sensing circuit means in response to the control signal from the controller means, whereby the sensing circuit means periodically detects said voltage in synchrony with the operation of the current generator means; and

(v) an output terminal means for carrying the detector'"'"'s output signal.

2. The system of claim 1 wherein the synchronizer means comprises an electrically controlled switch responsive to the control signal from the controller means, and wherein the sensing circuit means comprises:

(a) an amplifier means, coupled to the input terminal means of the bioimpedance detector means, for receiving and amplifying said voltage as an output signal; and

(b) an analog-to-digital converter means, responsive to the output signal of the amplifier, and responsive to the periodic control signal of the controller means, for periodically converting the output signal of the amplifier to a digital output signal representative of impedance in the human or animal body segment between the first and the second portions.

3. The system of claim 2 wherein the sensing circuit means further comprises a digital differentiator means, responsive to the digital output signal of the analog-to-digital converter means, for generating data representing a differentiated voltage output signal having a magnitude proportional to a rate of change of electrical bioimpedance in the human or animal body segment between the first and the second portions.

4. The system of claim 3 wherein the bioimpedance detector means further comprises a delay circuit means, connected in series between the amplifier means and the analog-to-digital converter means, for sampling and holding the output signal of the amplifier means for later retrieval by the analog-to-digital converter means.

5. The system of claim 2 wherein the sensing circuit means further comprises a processor, responsive to the digital output signal of the analog-to-digital converter means, for processing data.

6. The system of claim 1 wherein the current generator further comprises:

(a) a current source means for generating a high frequency current output, the current source means being coupled across the output terminal means of the current generator means; and

(b) an electrically controlled switch coupled to the current source means, for regulating the operation of the current source means in response to the control signal from the controller means, whereby the current source means generates a current output only when the switch is closed.

7. The system of claim 1 wherein the controller means further comprises a timing circuit means, coupled to the output terminal of the controller means, for generating the periodic control output signal.

8. The system of claim 7 wherein the timing circuit means is a microprocessor.

9. A method of determining or measuring fluid content or fluid flow in a human or animal body segment, comprising:

(a) periodically generating a high frequency current;

(b) applying the current to a first and a second portion of the human or animal body segment;

(c) periodically detecting a voltage between a third and a fourth portion of the human or animal body segment, wherein the third and the fourth portions are located proximate the first and the second portion of the human or animal body segment and the detected voltage is caused by impedance to the current flow in the human or animal body segment between the third and the fourth portions, wherein the periodic detection of the voltage is in synchrony with the periodic generation of the current; and

(d) generating a signal based on the detected voltage, wherein the signal is indicative of impedance in the human or animal body segment between the third and the fourth portions.

10. A method of determining or measuring fluid content or fluid flow in a human or animal body segment, comprising:

(a) periodically applying a high frequency current to a first and a second portion of the human or animal body segment;

(b) periodically detecting a voltage between a third and a fourth portion of the human or animal body segment, wherein the third and the fourth portions are located proximate the first and the second portion of the human or animal body segment and the detected voltage is caused by impedance to the current flow in the human or animal body segment between the third and the fourth portions, wherein the detection of the voltage is in synchrony with periodic application of the current; and

(c) generating a signal based on the detected voltage, wherein the signal is indicative of impedance in the human or animal body segment between the second and the fourth portions.