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Analytical work station

  • US 5,529,752 A
  • Filed: 12/22/1994
  • Issued: 06/25/1996
  • Est. Priority Date: 01/17/1989
  • Status: Expired due to Fees
First Claim
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1. A slide reading assembly comprising:

  • (a) a housing with a top, bottom, and inner and outer sidewall sections wherein the inner side wall section has a window with a photoresponsive electrode having an inner surface mounted above the window on the inside of the inner side wall section so that light from an external source can pass into and be absorbed within the photoresponsive electrode and said outer sidewall section has a surface;

    the top section of the housing having an opening for receiving a slide to be analyzed wherein the slide has a porous filter membrane with analyte to be determined on predetermined locations on the porous filter membrane, said housing having means for aligning the predetermined locations on the porous filter membrane on the inner surface of the photoresponsive electrode opposite the window in the housing which allow light to pass to a photoresponsive electrode;

    a resilient plunger mounted in the outer side wall surface of the housing opposite the photoresponsive electrode, the plunger having a stem and pad such that when the plunger stem is pushed inwardly, by an operatively associated stepping motor, into the housing the pad compresses the porous membrane against the inner surface of the photoresponsive electrode;

    a liquid chamber within the housing with exit and entrance ports for liquids in the top section of the housing and wherein the inner surface of the photoresponsive electrode is within the liquid chamber and the porous filter membrane is aligned above the inner surface of the photoresponsive electrode in the liquid chamber;

    (b) an intensity-modulated light source for independently irradiating the photoresponsive electrode through the window in the housing on each area of the photoresponsive electrode opposite the area of the porous filter having a predetermined location of filtered analyte or analyte complex; and

    (c) an electrical means for measuring a potential change of the surface of the photoresponsive electrode when the photoresponsive electrode is exposed to an intensity-modulated beam of light through the window in the housing and a chemical reaction is occurring between the filtered analyte or analyte complex on the porous filter membrane and a reagent in the liquid in the liquid chamber, the electrical means including a counter electrode, and an operation amplifier.

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