Apparatus for measuring a glucose concentration

• US 5,529,755 A
• Filed: 02/16/1995
• Issued: 06/25/1996
• Est. Priority Date: 02/22/1994
• Status: Expired due to Term

• Current Assignee: Minolta Co., Ltd. (Konica Minolta Inc.)
• Original Assignee: Minolta Co., Ltd. (Konica Minolta Inc.)
• Inventors: Ariizumi, Masahiro, Higashio, Kimihiko
• Primary Examiner(s): Snay, Jeffrey R.
• Application Number:
  US08/389,910
• Time in Patent Office: 495 Days
• Field of Search: 422/82.09, 436/95, 436/164, 128/633, 128/664, 356/39, 356/433-436, 250/339.04
• US Class Current: 422/82.09
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/6816 Ear lobe
• CPC Class Codes: A61B 5/6824 Arm or wrist
• CPC Class Codes: A61B 5/6826 Finger
• CPC Class Codes: A61B 5/6838 Clamps or clips
• CPC Class Codes: G01N 21/314 with comparison of measurements at specific and non-specific wavelengths dual wavelength spectrometry G01J3/427
• CPC Class Codes: Y10T 436/144444 Glucose

Abstract

A non-invasive glucose concentration measurement apparatus includes: a light source which projects at the sample radiation of a wavelength range including a wavelength at which absorption greatly changes with glucose concentration but does not greatly vary with temperature; a photosensor which receives the radiation which have been projected by the light source, and transmitted through or reflected by the sample, and generates an electrical signal corresponding to a through-transmitted or reflected level of the radiation of the wavelength; and a calculator which calculates a glucose concentration based on the electrical signal. A more accurate glucose concentration can be obtained without the influence of temperature.

Claims

1. An apparatus for noninvasively measuring a glucose concentration of a sample, the apparatus comprising:

a first light source which projects at the sample radiation of a wavelength range including a first wavelength λ

₁ at which absorption is dependent upon glucose concentration;

a second light source which projects at the sample radiation of a wavelength range including a second wavelength λ

₂, different from the first wavelength λ

₁, at which absorption has a temperature-dependent characteristic correlated with that in absorption of radiation of the first wavelength λ

₁ ;

a photosensor which receives the two kinds of radiation which have been projected by the first and second light sources, and transmitted through or reflected by the sample, and generates a first electrical signal corresponding to a through-transmitted or reflected level of the radiation of the first wavelength λ

₁ and a second electrical signal corresponding to a through-transmitted or reflected level of the radiation of the second wavelength λ

₂ ; and

a calculator which calculates a glucose concentration based on the first and second electrical signals.

2. An apparatus according to claim 1, wherein the first wavelength λ

1 lies within a range between 1560 nm and 1760 nm and the second wavelength λ

2 lies within a range between 1440 nm and 1560 nm.

3. An apparatus according to claim 1, wherein the first wavelength λ

1 lies within a range between 2080 nm and 2230 nm and the second wavelength λ

2 lies within a range between 2050 nm and 2080 nm.

4. An apparatus according to claim 1, wherein the photosensor includes an optical filter for separately receiving the radiation of the wavelength range including the first wavelength λ

1 and the radiation of the wavelength range including the second wavelength λ

2.

5. An apparatus according to claim 1, further comprising a pressing device which presses the sample, wherein:

the photosensor generates first and second electrical signals in a state of the sample being not pressed and first and second electrical signals in another state of the sample being pressed; and

the calculator calculates a glucose concentration based on the first and second electrical signals in the non-pressed state and the first and second electrical signals in the pressed state.

6. An apparatus according to claim 1, wherein the calculator calculates a glucose concentration in consideration of a variation in the through-transmitted or reflected radiation which is caused by pulsation of blood at a measured portion when the sample is an organism.

7. An apparatus according to claim 1, wherein the first wavelength λ

1 lies within a range between 2155 nm and 2225 nm and the second wavelength λ

2 lies within a range between 1200 nm and 1300 nm.

8. An apparatus for noninvasively measuring a glucose concentration of a sample, the apparatus comprising:

a light source which projects at the sample radiation of a wavelength range including a first wavelength λ

₁ at which absorption is dependent upon glucose concentration and a second wavelength λ

₂, different from the first wavelength λ

₁, at which absorption has a temperature-dependent characteristic correlated with that in absorption of radiation of the first wavelength λ

₁ ;

a photosensor which receives the two kinds of radiation which have been projected by the light source, and transmitted through or reflected by the sample, and generates a first electrical signal corresponding to a through-transmitted or reflected level of the radiation of the first wavelength λ

₁ and a second electrical signal corresponding to a through-transmitted or reflected level of the radiation of the second wavelength λ

₂ ; and

a calculator which calculates a glucose concentration based on the first and second electrical signals.

9. An apparatus according to claim 8, wherein the first wavelength λ

1 lies within a range between 1560 nm and 1760 nm and the second wavelength λ

2 lies within a range between 1440 nm and 1560 nm.

10. An apparatus according to claim 8, wherein the first wavelength λ

1 lies within a range between 2080 nm and 2230 nm and the second wavelength λ

2 lies within a range between 2050 nm and 2080 nm.

11. An apparatus according to claim 8, wherein the photosensor includes an optical filter for separately receiving the radiation of the wavelength range including the first wavelength λ

1 and the radiation of the wavelength range including the second wavelength λ

2.

12. An apparatus according to claim 8, further comprising a pressing device which presses the sample, wherein:

the photosensor generates first and second electrical signals in a state of the sample being not pressed and first and second electrical signals in another state of the sample being pressed; and

the calculator calculates a glucose concentration based on the first and second electrical signals in the non-pressed state and the first and second electrical signals in the pressed state.

13. An apparatus according to claim 8, wherein the calculator calculates a glucose concentration in consideration of a variation in the through-transmitted or reflected radiation which is caused by pulsation of blood at a measured portion when the sample is an organism.

14. An apparatus according to claim 8, wherein the first wavelength λ

1 lies within a range between 2155 nm and 2225 nm and the second wavelength λ

2 lies within a range between 1200 nm and 1300 nm.