Methods and compositions for the direct concentrated delivery of passive immunity
First Claim
1. A biomaterial, comprising:
- a device insertable into a human or animal host'"'"'s body at a surgical or trauma site of a wound, burn or biomaterial implant site, said device having a body contacting surface; and
an immunoglobulin composition coated on said surface of said device, said immunoglobulin composition comprising a combination of IgG, IgM and IgA, wherein said composition contains elevated levels of IgM between 200-300 mg/dl and IgA between 400-500 mg/dl when compared with normal serum levels, wherein said immunoglobulin composition is specific for microorganisms.
1 Assignment
0 Petitions
Accused Products
Abstract
Compositions containing a high concentration of the full repertoire of immunoglobulins, including IgA, IgM and IgG, are used to combat infections from microorganisms and viruses at a wound, surgical, or burn site, or normal tissue at times of risk of infection. The compositions can contain elevated antibody titers for several specific pathogens including S. aureus, CNS, Enterococci, S. epidermidis, P. aeruginosa, E. coli, and Enterobacter spp., etc. The compositions are applied directly to a wound or burn site as an ointment, creme, fluid, spray, or the like, prior to viral or bacterial attachment or biofilm formation such that adhesion of the pathogens is inhibited and the pathogens closest to the wound or burn site will be pre-opsonized for phagocytic killing prior to toxin release. The immunoglobulins in the composition can be immobilized on a biocompatible material such as collagen, fibrin, hyaluronan, biodegradable polymers, and fragments thereof, which will be placed in-situ at the wound, surgical or burn site. In addition, the immunoglobulins in the composition may be coated on the body contacting surface of an implantable device such as a catheter, contact lens or total joint. The inventive compositions have particular application in preventing infections.
93 Citations
7 Claims
-
1. A biomaterial, comprising:
a device insertable into a human or animal host'"'"'s body at a surgical or trauma site of a wound, burn or biomaterial implant site, said device having a body contacting surface; and
an immunoglobulin composition coated on said surface of said device, said immunoglobulin composition comprising a combination of IgG, IgM and IgA, wherein said composition contains elevated levels of IgM between 200-300 mg/dl and IgA between 400-500 mg/dl when compared with normal serum levels, wherein said immunoglobulin composition is specific for microorganisms.- View Dependent Claims (2, 3, 4, 5, 6, 7)
Specification