Method of manufacturing of hollow fiber cartridge with porous ring
First Claim
1. A method of sealingly coupling a hollow fiber bundle to a casing for encasing a bundle of hollow fibers comprising:
- (a) providing an annular porous collar having first and second outer peripheral edges, said collar including pores having a pore size distribution of from about 5 μ
m to about 500 μ
m;
(b) providing a casing having first and second longitudinal ends, said casing defining a central chamber, said chamber having a first and second open ends wherein said longitudinal ends of said casing each include an inner, lateral, annular lip proximal to each of said open ends;
(c) coupling said first outer peripheral edge of said annular porous collar to at least one of said inner, lateral, annular lips of said casing;
(d) retaining a bundle of hollow fibers having first and second longitudinal ends within said chamber;
(e) permeating said longitudinal ends of said hollow fiber bundle with a fluid impermeable material;
(f) joining said porous collar coupled to said casing to said hollow fiber bundle by penetration of said fluid impermeable material through said pores of said porous collar; and
(g) curing said fluid impermeable material, wherein a fluid impermeable seal is formed between said bundle of hollow fibers, said casing and said annular porous collar.
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Accused Products
Abstract
A method of sealingly coupling a hollow fiber bundle having first and seconds ends to a porous collar having first and second peripheral edges, at least one of which is coupled to the inner ledge of a casing for encasing said bundle of hollow fibers is disclosed. The method broadly includes providing a porous collar having first and second outer peripheral edges; providing a casing having first and second longitudinal ends, the casing defining a central chamber, the chamber having first and second open ends wherein the longitudinal ends of the casing each include an inner lip proximal to the open end; coupling the first outer peripheral edge of the porous collar to the inner lip of the casing; retaining a bundle of hollow fibers having first and second longitudinal ends within the chamber; permeating the longitudinal ends of the hollow fiber bundle with a fluid impermeable material; joining the porous collar to the fluid impermeable material by penetration of the material into the porous collar; and curing the fluid impermeable material. The method provides a fluid impermeable seal between the casing and the individual hollow fibers. The seal prevents the unfiltered fluid from coming into contact with filtrate and provides a strong bond that is impervious to dry heat and steam sterilization at temperatures ranging from 100° C. to 150° C. and pressures from 10 psi to 60 psi.
154 Citations
6 Claims
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1. A method of sealingly coupling a hollow fiber bundle to a casing for encasing a bundle of hollow fibers comprising:
-
(a) providing an annular porous collar having first and second outer peripheral edges, said collar including pores having a pore size distribution of from about 5 μ
m to about 500 μ
m;(b) providing a casing having first and second longitudinal ends, said casing defining a central chamber, said chamber having a first and second open ends wherein said longitudinal ends of said casing each include an inner, lateral, annular lip proximal to each of said open ends; (c) coupling said first outer peripheral edge of said annular porous collar to at least one of said inner, lateral, annular lips of said casing; (d) retaining a bundle of hollow fibers having first and second longitudinal ends within said chamber; (e) permeating said longitudinal ends of said hollow fiber bundle with a fluid impermeable material; (f) joining said porous collar coupled to said casing to said hollow fiber bundle by penetration of said fluid impermeable material through said pores of said porous collar; and (g) curing said fluid impermeable material, wherein a fluid impermeable seal is formed between said bundle of hollow fibers, said casing and said annular porous collar. - View Dependent Claims (2, 3, 4, 5, 6)
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Specification