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Side-chain homologous vitamin D derivatives, process for their production, pharmaceutical preparations containing these derivatives and their use as pharmaceutical agents

  • US 5,532,228 A
  • Filed: 06/01/1993
  • Issued: 07/02/1996
  • Est. Priority Date: 02/06/1990
  • Status: Expired due to Fees
First Claim
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1. Side-chain homologous vitamin D derivatives of formula I ##STR12## in which R1 means a hydrogen atom, a hydroxy or an acyloxy group with 1 to 9 carbon atoms,R2 means a hydrogen atom or an acyl group with 1 to 9 carbon atoms,R3 or R4 means a hydroxy or acyloxy group with 1 to 9 carbon atoms, and the respective other substituent is a hydrogen atom or R3 or R4 together mean an oxygen atom,R5 and R6, independently of one another, each mean a linear or branched alkyl radical with up to 5 carbon atoms, a trifluoromethyl group or together a saturated, unsaturated or aromatic carbocyclic 3-, 4-, 5- or 6-member ring formed with the tertiary carbon atom or with the inclusion of 1 or 2 N, O or S atoms a heterocyclic 3, 4, 5 or 6-member ring,B and D either mean a hydrogen atom each or together a second bond (E-configured double bond) and eitherA means a direct bond between carbon atoms 20 and 22 andX means an oxy alkylene radical --(CH2)n O-- with n=1 to 3 orA means a methylene bridge (--CH2 --) between carbon atoms 20 and 22 andX means an alkylene radical --(CH2)n -- or an oxy alkylene radical --(CH2)n O-- with n=1 to 3, or if A stands for a direct bond and B and D together stand for a second bond, ##STR13## means ##STR14##

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