Disposable inhaler

• US 5,533,505 A
• Filed: 09/02/1994
• Issued: 07/09/1996
• Est. Priority Date: 03/04/1992
• Status: Expired due to Term

• Current Assignee: Astra AB (Astrazeneca PLC)
• Original Assignee: Astra AB (Astrazeneca PLC)
• Inventors: Kallstrand, Goran, Nilsson, Per-Gunnar
• Primary Examiner(s): Asher, Kimberly L.
• Application Number:
  US08/295,709
• Time in Patent Office: 676 Days
• Field of Search: 128/203.15, 128/203.21, 128/203.12, 128/203.19, 128/203.23, 206/528, 604/58, 222/636
• US Class Current: 128/203.15
• CPC Class Codes: A61M 11/002 by flow deviation causing inertial separation of transported particles
• CPC Class Codes: A61M 15/0028 using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
• CPC Class Codes: A61M 15/0043 Non-destructive separation of the package, e.g. peeling
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2206/14 Static flow deviators in tubes disturbing laminar flow in tubes, e.g. archimedes screws

Abstract

The invention relates to a disposable breath-actuated inhaler comprising a tubular housing forming an air flow path being open at both ends, one end forming an air inlet (4) and one end forming an air outlet (5), the housing comprising a compartment (3) for storing a pharmaceutical powder to be inhaled. The compartment (3) for storing the pharmaceutical powder is located close to the air inlet (4) and is covered by a thin foil (6) sealing the compartment in an airtight way which can be removed from the compartment from outside the housing, the housing being shaped with a constriction (9) adjacent the powder compartment (3) such that a turbulent air stream will be obtained at the constriction upon inhalation which will lift the powder out from the compartment (3) and mix the powder into the air stream.

Claims

1. A disposable breath-actuated inhaler for delivering a dose of a finely divided powder to a patient comprising

a housing defining a chamber, said chamber having an air inlet,

an air outlet in fluid communication with the air inlet, and an air flow path extending between said inlet and said outlet

a compartment, containing a dose of finely divided powder, located in a region of said chamber intermediate said inlet and said outlet, said compartment defining a volume to hold the dose and having an opening which exposes a surface of said dose to said air flow path, said compartment including a through-hole positioned beneath the finely divided powder, said through hole selectively opened to ambient air to allow ambient air to enter the compartment,

a removable cover disposed sealingly over said opening in said compartment and confining the dose of finely divided powder within the compartment prior to delivery, and

a constriction means in said air flow path adjacent the powder compartment positioned to induce sufficient turbulence in an air stream produced upon removal of said removable cover and subsequent inhalation to lift the powder out from the compartment and mix the powder into the air stream for delivery through the air outlet.

2. An inhaler according to claim 1 wherein said powder compartment includes a plurality of through-holes.

3. An inhaler according to claim 1, wherein said housing comprises an upper half and a substantially flat lower half having an indentation forming the powder compartment, said two halves being sealingly joined along their longitudinal sides.

4. An inhaler according to claim 3, wherein the upper part is moulded from a thin plastic sheet.

5. An inhaler according to claim 3 or 4, wherein said constriction means is formed as a depression in said upper part which depression is oriented transversely relative to the longitudinal extent of the tubular housing and located above the powder compartment.

6. An inhaler according to claim 3, wherein the lower half comprises a laminate including an aluminum foil layer and a plastic layer.

7. An inhaler according to claim 1, wherein the cover comprises a thin foil in the shape of a tape having a free end extending out through the air inlet, said tape being attached around the edges of the powder compartment by relatively weak welds.

8. An inhaler according to claim 7, wherein an inner end of the tape, spaced from said free end, is attached to an inner surface of the lower half between the air inlet and the powder compartment, and the tape extends away from the air inlet past the powder compartment, and then bends backwards so as to extend toward and out through the air inlet.

9. An inhaler according to claim 8, wherein the weak welds form a point facing downstream in the airflow path in order to facilitate the initiation of the tearing action along the welds when the tape is pulled out of the housing to expose the powder.

10. An inhaler according to claim 8 wherein said free end of said tape is attached to an outer surface of said lower part and positioned to seal said through-hole.

11. An inhaler according to claim 1 wherein said housing further comprises a projection extending downwardly from the upper half between the powder compartment and the air inlet for holding the tape against the lower half of the housing in order to prevent the tape from obstructing the air flow path.

12. An inhaler according to claim 1 wherein said housing further comprises deaggregation means located in the air flow path between the powder compartment and the air outlet.

13. An inhaler according to claim 11, wherein said deaggregation means comprise a plurality of planar surfaces defining said air flow path, each surface being oriented at an angle of from about 20°

-50°

relative to the longitudinal direction of the tubular housing, said surfaces being disposed generally perpendicularly to a plane through the longitudinal axis of the tubular housing, a projection of the planar surfaces onto a cross-section of the housing substantially covering said cross-section.

14. An inhaler according to claim 13 wherein said angle is from about 25°

-35°

.

15. An inhaler according to claim 1 wherein said compartment includes two through-holes.

16. An inhaler according to claim 15 wherein said through-holes are positioned at a deepest portion of said compartment.

17. An inhaler according to claim 1 wherein said removable cover is removable from outside the housing.

18. An inhaler according to claim 17 wherein said cover comprises a thin foil.

19. An inhaler according to claim 17 or 18 wherein said housing comprises an upper half and a substantially flat lower half having an indentation defining the powder compartment, said two halves being sealingly joined along their longitudinal edges.