Apparatus and method for noninvasive blood pressure measurement

• US 5,533,511 A
• Filed: 01/05/1994
• Issued: 07/09/1996
• Est. Priority Date: 01/05/1994
• Status: Expired due to Term

• Current Assignee: Masimo Corporation
• Original Assignee: Vital Insite, Inc.
• Inventors: Stern, Roger A., Kaspari, William J.
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): NASSER, ROBERT L
• Application Number:
  US08/177,448
• Time in Patent Office: 916 Days
• Field of Search: 128/632, 128/633-5, 128/637, 128/661.08, 128/661.09, 128/662.1, 128/664-668, 128/672-696, 128/702, 128/703-705, 128/713, 128/716-732 , 128/736, 128/748
• US Class Current: 600/485
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: Y10S 128/925 Neural network

Abstract

A blood pressure monitor for determining a patient'"'"'s blood pressure comprises a processor attached to a first input device for receiving an initial input representing the patient'"'"'s absolute blood pressure, and a noninvasive sensor attached to the patient for measuring at least one physiological function. The processor executes a procedure for evaluating the initial input and the sensed physiological function to determine the patient'"'"'s blood pressure. A method for determining a patient'"'"'s blood pressure comprises the steps of storing an initial input representing a patient'"'"'s absolute blood pressure, noninvasively sensing at least one of the patient'"'"'s physiological functions, and evaluating the initial input and the sensed input to determine the patient'"'"'s blood pressure. The present invention can also be used to analyze and track other physiological variables such as vascular wall compliance, changes in the strength of ventricular contractions, changes in vascular resistance, changes in fluid volume, changes in cardiac output, myocardial contractility and other related factors.

Claims

1. A blood pressure monitor for measuring a patient'"'"'s blood pressure, comprising:

memory means for storing reference features representative of blood pressure from a population of reference patients;

means for periodically obtaining calibration blood pressure values from the patient, said calibration blood pressure values representing the patient'"'"'s absolute blood pressure;

means for noninvasively obtaining blood pressure pulses from the patient;

processing means for processing said blood pressure pulses to obtain processed features representative of said blood pressure pulses;

comparing means for comparing said processed features with said reference features to provide comparison signals representative of the comparison of said processed features with said reference features; and

scaling means responsive to said calibration blood pressure values and said blood pressure pulses for scaling said comparison signals to provide the patient'"'"'s true blood pressure.

2. The blood pressure monitor of claim 1, wherein:

said means for noninvasively obtaining blood pressure pulses is a piezoelectric sensor.

3. The blood pressure monitor of claim 1, wherein:

said processing means includes means for processing said blood pressure pulses to obtain processed time domain features representative of said blood pressure pulses.

4. The blood pressure monitor of claim 1, wherein:

said processing means includes means for transforming said blood pressure pulses from the time domain to the frequency domain; and

said processed features are frequency domain features.

5. The blood pressure monitor of claim 1, wherein:

said processing means includes means for transforming said blood pressure pulses from the time domain to the frequency domain; and

said processed features are a combination of time domain features and frequency domain features.

6. The blood pressure monitor of claim 1, wherein:

said comparing means compares a curve fit of said processed features with said reference features.

7. The blood pressure monitor of claim 1, wherein:

said comparing means compares a classification of said processed features with a classification of said reference features.

8. The blood pressure monitor of claim 1, wherein:

said comparing means includes means for comparing said processed features with said reference features that are determined by a neural network.

9. The blood pressure monitor of claim 1, wherein:

said memory means includes means for storing historical processed features as stored features, said stored features being one of the group consisting of historical processed features occurring before obtaining a calibration blood pressure value, historical processed features occurring after obtaining a calibration blood pressure value, historical processed features occurring before and after obtaining a calibration blood pressure value, and historical processed features occurring while obtaining a calibration blood pressure value; and

said comparing means further includes means for comparing said processed features with said stored features to provide said comparison signals.

10. The blood pressure monitor of claim 1, wherein:

said comparing means includes means for triggering said means for periodically obtaining calibration blood pressure values, when said comparing means detects a predetermined criteria.

11. The blood pressure monitor of claim 1, wherein:

said comparing means includes a neural network.

12. A method of determining a patient'"'"'s blood pressure comprising the steps of:

storing reference features representative of blood pressure from a population of reference patients;

periodically obtaining calibration blood pressure values from the patient, said calibration blood pressure values representing the patient'"'"'s absolute blood pressure;

noninvasively obtaining blood pressure pulses from the patient;

processing said blood pressure pulses to obtain processed features representative of said blood pressure pulses;

comparing said processed features with said reference features to provide comparison signals representative of the comparison of said processed features with said reference features; and

scaling said comparison signals with respect to said calibration blood pressure values and said blood pressure pulses to provide the patient'"'"'s true blood pressure.

13. The method of claim 12, wherein:

said processing step includes obtaining time domain features.

14. The method of claim 12, wherein:

said processing step includes a step of transforming said blood pressure pulses from the time domain to the frequency domain; and

said processing step includes obtaining frequency domain features.

15. The method of claim 12, wherein:

said processing step includes a step of transforming said blood pressure pulses from the time domain to the frequency domain; and

said processing step includes obtaining a combination of time domain features and frequency domain features.

16. The method of claim 12, wherein:

said comparing step includes comparing a curve fit of the processed features with said reference features.

17. The method of claim 12, wherein:

said comparing step includes comparing a classification of the processed features with a classification of said reference features.

18. The method of claim 12, wherein:

said comparing step includes comparing the processed features with said reference features, wherein said reference features are determined by a neural network.

19. The method of claim 12, further comprising the step of:

storing historical processed features as stored features, said stored features being one of the group consisting of historical processed features occurring before obtaining a calibration blood pressure value, historical processed features occurring after obtaining a calibration blood pressure value, historical processed features occurring before and after obtaining a calibration blood pressure value, and historical processed features occurring while obtaining a calibration blood pressure value; and

wherein

said comparing step further includes comparing said processed features with said stored features to provide said comparison signals.

20. The method of claim 12, wherein:

said comparing step includes initiating said calibration step when said comparing step detects a predetermined criteria.

21. A monitor for measuring a waveform representing a patient'"'"'s physiological function, said monitor comprising:

memory means for storing reference features representative of reference waveforms from a population of reference patients, said reference waveforms being representative of the reference patients'"'"' physiological function;

means for periodically obtaining a calibration waveform from the patient representative of the patient'"'"'s physiological function;

means for obtaining a waveform representative of the patient'"'"'s physiological function;

processing means for processing said obtained waveform to obtain processed features;

comparing means for comparing said processed features with said reference features to provide a comparison signal; and

means responsive to said calibration waveform and said obtained waveform for scaling the comparison signal to provide a signal representative of the patient'"'"'s physiological function.

22. A monitor as in claim 21, wherein:

said memory means includes means for storing reference features representative of reference waveforms from a population of reference patients, said reference waveforms being representative of the reference patients'"'"' blood flow;

said means for periodically obtaining a calibration waveform from the patient includes means for obtaining a calibration waveform representative of the patient'"'"'s blood flow;

said means for obtaining a waveform representative of the patient'"'"'s physiological function includes means for obtaining a waveform representative of the patient'"'"'s blood flow; and

said means responsive to said calibration waveform and said obtained waveform for scaling the comparison signal to provide a signal representative of the patient'"'"'s physiological function includes means responsive to said calibration waveform and said obtained waveform for scaling the comparison signal to provide a signal representative of the patient'"'"'s blood flow.

23. A monitor as in claim 21, wherein:

said memory means includes means for storing reference features representative of reference waveforms from a population of reference patients, said reference waveforms being representative of the reference patients'"'"' blood pressure;

said means for periodically obtaining a calibration waveform from the patient includes means for obtaining a calibration waveform representative of the patient'"'"'s blood pressure;

said means for obtaining a waveform representative of the patient'"'"'s physiological function includes means for obtaining a waveform representative of the patient'"'"'s blood pressure; and

said means responsive to said calibration waveform and said obtained waveform for scaling the comparison signal to provide a signal representative of the patient'"'"'s physiological function includes means responsive to said calibration waveform and said obtained waveform for scaling the comparison signal to provide a signal representative of the patient'"'"'s blood pressure.

24. A monitor as in claim 21, wherein:

said memory means includes means for storing reference features representative of reference waveforms from a population of reference patients, said reference waveforms being representative of the reference patients'"'"' physiological function, where said physiological function is one of the group consisting of blood pressure, heart beat, vascular wall compliance, strength of vascular contractions, vascular resistance, fluid volume, cardiac output, and myocardial contractility;

said means for periodically obtaining a calibration waveform from the patient includes means for obtaining a calibration waveform representative of the patient'"'"'s physiological function, where said physiological function is one of the group consisting of blood pressure, heart beat, vascular wall compliance, strength of vascular contractions, vascular resistance, fluid volume, cardiac output, and mlyocardial contractility;

said means for obtaining a waveform representative of the patient'"'"'s physiological function includes means for obtaining a waveform representative of the patient'"'"'s physiological function, where said physiological function is one of the group consisting of blood pressure, heart beat, vascular wall compliance, strength of vascular contractions, vascular resistance, fluid volume, cardiac output, and myocardial contractility; and

said means responsive to said calibration waveform and said obtained waveform for scaling the comparison signal to provide a signal representative of the patient'"'"'s physiological function includes means responsive to said calibration waveform and said obtained waveform for scaling the comparison signal to provide a signal representative of the patient'"'"'s physiological function, where said physiological function is one of the group consisting of blood pressure, heart beat, vascular wall compliance, strength of vascular contractions, vascular resistance, fluid volume, cardiac output, and myocardial contractility.

25. The monitor of claim 21, wherein:

said memory means for storing reference features representative of reference waveforms from a population of reference patients includes means for storing reference features that are determined by a neural network, said reference waveforms being representative of the reference patients'"'"' physiological function.

26. A method of monitoring a patient'"'"'s physiological function, comprising the steps of:

storing reference features representative of reference waveforms from a population of reference patients, said reference waveforms being representative of the reference patients'"'"' physiological function;

periodically obtaining a calibration waveform from the patient, said calibration waveform being representative of the patient'"'"'s physiological function;

obtaining a waveform representative of the patient'"'"'s physiological function;

processing said obtained waveform to obtain processed features;

comparing said processed features with said reference features to provide a comparison signal; and

scaling the comparison signal with respect to the calibration waveform and the obtained waveform to provide a signal representative of the patient'"'"'s physiological function.

27. The method of claim 26, wherein:

said physiological function is related to the patient'"'"'s blood flow.

28. The method of claim 26, wherein:

said physiological function is blood pressure.

29. The method of claim 26, wherein:

said physiological function is one of the group consisting of blood pressure, heart beat, vascular wall compliance, strength of vascular contractions, vascular resistance, fluid volume, cardiac output, and myocardial contractility.

30. The method of claim 26, wherein:

said storing step includes the step of storing reference features determined by a neural network and representative of reference waveforms from a population of reference patients said reference waveforms being representative of the reference patients'"'"' physiological function.