Method and apparatus for detection of venous air emboli

• US 5,533,512 A
• Filed: 03/18/1994
• Issued: 07/09/1996
• Est. Priority Date: 03/18/1994
• Status: Expired due to Term

• Current Assignee: Datex-Ohmeda Incorporated (General Electric Company)
• Original Assignee: Ohmeda, Inc. (Linde Plc)
• Inventors: Graybeal, John M., Novotny, Mark A., Russell, Garfield B., Geisler, Jeffrey D., Boone, Thomas A.
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): HUANG, STEPHEN D
• Application Number:
  US08/210,883
• Time in Patent Office: 844 Days
• Field of Search: 128/716, 128/719
• US Class Current: 600/532
• CPC Class Codes: A61B 5/083 Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
• CPC Class Codes: A61B 5/417 the bone marrow

Abstract

Concomitant measurement of EtCO₂, EtN₂ and (FiO₂ -FeO₂) concentrations are used to detect a VAE. In a respiratory gas monitoring system, continuous measurements of end-tidal carbon dioxide, end-tidal nitrogen and the difference between inspired and expired oxygen concentrations are averaged using a predetermined time period and stored as historical data. Periodically, a present value of each of these concentrations is compared to its respective historical average for a predetermined time period. If the following conditions are met, the device signals the presence of a venous air embolism: 1) a decrease in the EtCO₂ concentration of 1.5 mm Hg; 2) an increase in the FeN₂ concentration of 0.03 vol %; and 3) a decrease in the difference between the inspired oxygen concentration and the expired oxygen concentration of 0.20 vol %.

Claims

1. An apparatus for detecting an air embolism comprising:

a respiratory gas nitrogen detector for detecting nitrogen in respiratory gases, said respiratory gas nitrogen detector having a signal output port which provides a nitrogen concentration signal representative of a concentration of the nitrogen detected in the respiratory gases; and

a processor having a signal input port connected to said respiratory gas nitrogen detector signal output port, said processor further comprising;

an historical data base of previously acquired nitrogen concentration signals;

a threshold analyzer having an input which receives the previously acquired nitrogen concentration signals from said historical data base and an output which provides a nitrogen concentration baseline threshold value according to a predetermined analysis criteria;

a current data register which receives and stores a current nitrogen concentration signal from said respiratory gas nitrogen detector; and

a comparator which compares the current nitrogen concentration signal with the nitrogen concentration baseline threshold value derived from said historical data base and triggers a venous air embolism alarm signal if the current nitrogen concentration signal crosses within a predetermined time window.

2. An apparatus as defined in claim 1 wherein said respiratory gas nitrogen detector is a Raman gas analyzer.

3. An apparatus as defined in claim 1 wherein:

said threshold analyzer further comprises a peak detector which searches said historical data base of previously acquired nitrogen concentration signals;

determines a maximum historical nitrogen concentration value therein; and

sets the nitrogen concentration baseline threshold value equal to the maximum historical nitrogen concentration value; and

said comparator further comprises a difference unit which determines a difference between the maximum historical nitrogen concentration value and the current nitrogen concentration signal held in the current data register and triggers the venous air embolism alarm signal if the difference exceeds a predetermined difference criteria.

4. An apparatus as defined in claim 1 wherein said historical data base of previously acquired nitrogen concentration signals and the current nitrogen concentration signal are end-tidal nitrogen concentrations, FeN₂.

5. An apparatus as defined in claim 1 wherein said threshold analyzer further comprises an averager which determines an average historical value derived from the historical data base of previously acquired nitrogen concentration signals and gets the nitrogen concentration baseline threshold value equal to the average historical value.

6. An apparatus for detecting an air embolism comprising:

a respiratory gas detector which detects carbon dioxide and nitrogen in respiratory gases, said respiratory gas detector having a signal output port which provides a carbon dioxide concentration signal and a nitrogen concentration signal which are representative of a concentration of carbon dioxide and a concentration of nitrogen, respectively, in the respiratory gases; and

a comparator having a signal input port connected to said respiratory gas detector signal output port wherein said comparator compares said carbon dioxide and nitrogen concentration signals with a predetermined carbon dioxide concentration threshold and a predetermined nitrogen concentration threshold, respectively, said comparator having an output which triggers an air embolism alarm when said carbon dioxide and nitrogen concentrations both cross said predetermined carbon dioxide concentration threshold and said predetermined nitrogen concentration threshold, respectively, within a predetermined time window.

7. An apparatus as defined in claim 6 wherein said respiratory gas detector is a Raman gas analyzer.

8. An apparatus as defined in claim 6 wherein:

said respiratory gas detector further comprises means for detecting oxygen in the respiratory gases, said means for detecting oxygen having a signal output port which provides an oxygen concentration signal which is representative of a concentration of oxygen in the respiratory gases; and

said comparator further comprises a predetermined oxygen concentration threshold and triggers said air embolism alarm when said carbon dioxide, nitrogen and oxygen concentration signals cross said predetermined carbon dioxide concentration threshold, said predetermined nitrogen concentration threshold and said predetermined oxygen concentration threshold, respectively, within said predetermined time window.

9. An apparatus for detecting an air embolism comprising:

a detector means for detecting nitrogen and carbon dioxide in respiratory gases;

a gas analyzer means for determining a plurality of breath-by-breath inspired and expired concentrations of the nitrogen and carbon dioxide detected by said detector means in the respiratory gases;

an end-tidal carbon dioxide analyzer means which receives the plurality of breath-by-breath inspired and expired concentrations of the carbon dioxide from said gas analyzer means and determines a plurality of breath-by-breath end-tidal carbon dioxide concentration values, EtCO₂, therefrom for a plurality of breaths;

an end-tidal carbon dioxide data memory means for storing the plurality of breath-by-breath end-tidal carbon dioxide concentration values, EtCO₂, received from said end-tidal carbon dioxide analyzer means as a function of time;

a nitrogen analyzer means which receives the plurality of breath-by-breath inspired and expired concentrations of the nitrogen from said gas analyzer means and determines a plurality of breath-by-breath expired nitrogen concentration values, FeN₂, therefrom for a plurality of breaths;

an expired nitrogen data memory means for storing the plurality of breath-by-breath expired nitrogen concentration values, FeN₂, received from said nitrogen analyzer means as a function of time; and

a processor means which

     1) compares a current breath value of EtCO₂ for a current breath with the plurality of breath-by-breath end-tidal carbon dioxide concentration values, EtCO₂, stored in said end-tidal carbon dioxide data memory means and sets an EtCO₂ TRUE flag for the current breath is a predetermined EtCO₂ comparison criteria is satisfied;

     2) compares a corresponding current breath value of FeN₂ for the current breath with the plurality of breath-by-breath expired nitrogen concentration values, FeN₂, stored in said expired nitrogen data memory means and sets an FeN₂ TRUE flag for the current breath if a predetermined FeN₂ comparison criteria is satisfied; and

     3) signals an alarm if the EtCO₂ TRUE flag for the current breath and the FeN₂ TRUE flag for the current breath are both set.

10. An apparatus as defined in claim 9 further comprising:

said detector means which further comprises an oxygen detector means which detects oxygen in the respiratory gases;

said gas analyzer means which further comprises an oxygen analyzer means which determines a plurality of breath-by-breath inspired and expired concentrations of the oxygen detected by said oxygen detector means in the respiratory gases;

an oxygen analyzer means which receives the plurality of breath-by-breath inspired and expired concentrations of the oxygen from said oxygen analyzer means and determines a plurality of breath-by-breath inspired oxygen minus expired oxygen concentration values, FiO₂ -FeO₂, therefrom for a plurality of breaths;

an oxygen data memory means for storing the plurality of breath-by-breath inspired oxygen minus expired oxygen concentration values, FiO₂ -FeO₂, received from said oxygen analyzer means as a function of time; and

said processor means further comprises means which

     4) compares a current breath value of FiO₂ -FeO₂ for the current breath with the plurality of breath-by-breath inspired oxygen minus expired oxygen concentration values, FiO₂ -FeO₂, stored in said oxygen data memory means and sets an FiO₂ -FeO₂ comparison criteria is satisfied; and

     5) signals an alarm if the EtCO₂ TRUE flag for the current breath, the FeN₂ TRUE flag for the current breath and the FiO₂ -FeO₂ TRUE flag for the current breath are all set.

11. An apparatus as defined in claim 9 wherein said detector means is a Raman gas analyzer.

12. An apparatus as defined in claim 9 further comprising:

a maximum value detector means which extracts a maximum FeN₂ value from the plurality of breath-by-breath expired nitrogen concentration values, FeN₂, as a function of time which are stored in the expired nitrogen data memory means; and

a comparator means which compares the corresponding current breath value of FeN₂ with the maximum FeN₂ value and triggers an alarm when the corresponding current breath value of FeN₂ exceeds the maximum FeN₂ value by at least 0.01 vol %.

13. An apparatus as defined in claim 9 further comprising:

a minimum value detector means which extracts a minimum EtCO₂ value from the plurality of breath-by-breath end-tidal carbon dioxide concentration values, EtCO₂, as a function of time which are stored in the end-tidal carbon dioxide data memory means; and

a comparator means which compares the current breath value of EtCO₂ with the minimum EtCO₂ value and triggers an alarm when the current breath value of EtCO₂ is lower the minimum EtCO₂ value by at least 1.0 mmHg.

14. A method of automatically detecting an air embolism comprising:

detecting nitrogen in respiratory gases;

determining, from the nitrogen detected in the respiratory gases, a plurality of breath-by-breath expired nitrogen concentrations for a plurality of breaths and storing the plurality of breath-by-breath expired nitrogen concentrations in a nitrogen historical data base;

comparing a recent expired nitrogen concentration value of the plurality of breath-by-breath expired nitrogen concentrations with the plurality of breath-by-breath expired nitrogen concentrations stored in the nitrogen historical data base; and

signalling an air embolism event when the recent expired nitrogen concentration value of the plurality of breath-by-breath expired nitrogen concentrations crosses a nitrogen baseline threshold derived from the nitrogen historical data base of breath-by-breath expired nitrogen concentrations.

15. A method as defined in claim 14 further comprising:

detecting carbon dioxide in respiratory gases;

determining, from the carbon dioxide detected in the respiratory gases, a plurality of breath-by-breath end-tidal carbon dioxide concentrations for a plurality of breaths and storing the plurality of breath-by-breath end-tidal carbon dioxide concentrations in a carbon dioxide historical data base;

comparing a recent end-tidal carbon dioxide concentration value of the plurality of breath-by-breath end-tidal carbon dioxide concentrations with the plurality of breath-by-breath end-tidal carbon dioxide concentrations stored in the carbon dioxide historical data base; and

signalling the air embolism event when the recent end-tidal carbon dioxide concentration value of the plurality of breath-by-breath end-tidal carbon dioxide concentrations crosses a carbon dioxide baseline threshold derived from the carbon dioxide historical data base of breath-by-breath end-tidal carbon dioxide concentrations and the recent expired nitrogen concentration value of the plurality of breath-by-breath expired nitrogen concentrations crosses the nitrogen baseline threshold derived from the nitrogen historical data base of breath-by-breath expired nitrogen concentrations.

16. A method as defined in claim 15 wherein signalling the air embolism event further comprises:

defining the nitrogen baseline threshold to be a maximum expired nitrogen concentration in the nitrogen historical data base; and

setting a nitrogen trigger when the recent expired nitrogen concentration value of the plurality of breath-by-breath expired nitrogen concentrations exceeds the nitrogen baseline threshold by at least 0.01 vol %.

17. A method as defined in claim 15 wherein signalling the air embolism event further comprises:

defining the carbon dioxide baseline threshold to be a minimum end-tidal carbon dioxide concentration in the carbon dioxide historical data base; and

setting an end-tidal carbon dioxide trigger when the recent end-tidal carbon dioxide concentration value of the plurality of breath-by-breath end-tidal carbon dioxide concentrations is lower than the carbon dioxide baseline threshold by at least 1.0 mmHg.

18. A method as defined in claim 14 wherein signalling an air embolism event further comprises:

defining the nitrogen baseline threshold to be a maximum expired nitrogen concentration in the nitrogen historical data base; and

triggering a nitrogen error alarm when the recent expired nitrogen concentration value of the plurality of breath-by-breath expired nitrogen concentrations exceeds the nitrogen baseline threshold by at least 0.01 vol %.