Apparatus for removal of excess hydrogen ions from humans

• US 5,533,964 A
• Filed: 02/17/1994
• Issued: 07/09/1996
• Est. Priority Date: 02/17/1994
• Status: Expired due to Fees

• Current Assignee: Rossmark Medical Publishers Incorporated
• Original Assignee: Rossmark Medical Publishers Incorporated
• Inventors: Halperin, Mitchell L., Cheema-Dhadli, Surinder
• Primary Examiner(s): Prebilic, Paul B.
• Application Number:
  US08/197,949
• Time in Patent Office: 873 Days
• Field of Search: 604/4, 604/5, 604/6, 604/190, 604/226, 604/236, 604/406, 424/424
• US Class Current: 604/6.09
• CPC Class Codes: A61K 33/38 Silver; Compounds thereof

Abstract

A compound or composition incorporating silver carbonate is disclosed for use in removing excess hydrogen ions in a patient. The silver carbonate reacts with chloride ions which naturally occur in the patient'"'"'s body fluids to produce a silver chloride precipitate. The chemical reaction producing silver chloride causes the release of hydroxyl, carbonate and/or bicarbonate ions which react with free hydrogen ions to form carbon dioxide and water. The silver carbonate compound or composition may be provided in a blood filtration cartridge, syringe or an orally ingestible form surrounded by a selectively permeable membrane. The membrane is selected to permit movement of ions, as well as carbon dioxide and water molecules therethrough, while preventing the silver carbonate or silver chloride precipitate from being released into the patient.

Claims

1. A kit for reducing hydrogen ions in a patient'"'"'s body fluid, said kit including,

a buffering compound comprising Ag₂ CO₃ in solid form for bonding with free cloride ions naturally present in said body fluid and substituting therefor buffering ions selected from the group consisting of carbonate ions and bicarbonate ions, and

means for selectively permitting ion flow between the patient'"'"'s body fluid and said buffering compound while preventing movement of said buffering compound into said patient,

wherein in use, said buffering ions bond with said hydrogen ions to produce water and carbon dioxide molecules.

3. A kit as claimed in claim 1 wherein said fluid comprises blood, said kit further comprising,

means for extracting a quantity of said blood from a patient for buffering by said compound, and

means for reintroducing buffered blood into said patient.

4. A kit as claimed in claim 1 wherein said means for selectively permitting ion flow comprises a selectively permeable membrane.

5. A kit as claimed in claim 4 wherein said membrane is a natural cellulose membrane.

2. A kit for use in buffering excess hydrogen ions in a patient, said kit comprising,

a buffering composition comprising a resin and Ag₂ CO₃ for bonding with free chloride ions naturally present in the patient and substituting therefor buffering ions selected from the group consisting of carbonate ions and bicarbonate ions, and

means for selectively permitting ion flow between a patient'"'"'s body fluid and said buffering composition while preventing movement of said buffering composition into said patient,

wherein in use, said buffering ions bond with said hydrogen ions to produce water and carbon dioxide molecules.

6. A kit as claimed in claim 2 wherein said fluid comprises blood, said kit further comprising,

means for extracting a quantity of said blood from a patient for buffering by said composition, and

means for reintroducing buffered blood into said patient.

7. A kit as claimed in claim 2 wherein said means for selectively permitting ion flow comprises a selectively permeable membrane.

8. A kit as claimed in claim 7 wherein said membrane is a natural cellulose membrane.

9. A kit as claimed in claim 8 wherein said resin is selected from the group consisting of an anion exchanger on dextran, an anion exchanger on agarose, an anion exchanger on cellulose and an anion exchanger on polystyrene.

10. An apparatus for use in buffering excess hydrogen ions in a patient'"'"'s blood, said apparatus comprising,

a housing having a reaction chamber and a blood chamber,

a hydrogen ion buffering compound comprising Ag₂ CO₃ disposed in said reaction chamber, said buffering compound for bonding with free chloride ions naturally present in said blood and substituting therefor buffering ions selected from the group consisting of carbonate ions and bicarbonate ions, and

said reaction chamber separated from said blood chamber by a membrane selectively permeable to permit the passage of free ions therethrough while preventing movement of said compound thereacross,

wherein in use, said buffering ions bond with said hydrogen ions to produce water and carbon dioxide molecules.

11. An apparatus as claimed in claim 10 further comprising means for extracting a quantity of blood from said patient to said housing for buffering by said compound, and

means for reintroducing buffered blood into said patient.

12. A syringe for use in buffering excess hydrogen ions in a patient'"'"'s blood, said syringe comprising,

a housing having a reaction chamber and a blood chamber,

a hydrogen ion buffering composition comprising Ag₂ CO₃ and a resin disposed in said reaction chamber, said buffering composition for bonding with free chloride ions naturally present in said blood and substituting therefor buffering ions selected from the group consisting of carbonate ions and bicarbonate ions,

said reaction chamber separated from said blood chamber by a membrane disposed across said housing and selectively permeable to permit the movement of free ions therethrough while preventing movement of said composition thereacross,

means for drawing a quantity of said blood from said patient into said housing and then reintroducing said blood into said patient,

wherein in use, said buffering ions bond with said hydrogen ions to produce water and carbon dioxide molecules.