Storage and transfer bottle designed for storing two components of a medicamental substance

• US 5,533,994 A
• Filed: 10/18/1993
• Issued: 07/09/1996
• Est. Priority Date: 12/27/1988
• Status: Expired due to Term

• Current Assignee: Becton Dickinson France (Becton, Dickinson & Co)
• Original Assignee: Becton Dickinson France (Becton, Dickinson & Co)
• Inventors: Meyer, Gabriel
• Primary Examiner(s): Rimell, Sam
• Application Number:
  US08/138,877
• Time in Patent Office: 995 Days
• Field of Search: 604/403, 604/404, 604/406, 604/408, 604/410, 604/415, 604/416, 215/DIG. 3
• US Class Current: 604/416
• CPC Class Codes: A61J 1/10 Bag-type containers
• CPC Class Codes: A61J 1/1475 Inlet or outlet ports
• CPC Class Codes: A61J 1/201 having one piercing end
• CPC Class Codes: A61J 1/2031 having openings brought into alignment
• CPC Class Codes: A61J 1/2037 having valve means
• CPC Class Codes: A61J 1/2041 having removable plugs
• CPC Class Codes: A61J 1/2051 having tap means, e.g. tap means activated by sliding
• CPC Class Codes: A61J 1/2055 having gripping means
• CPC Class Codes: A61J 1/2058 having multiple connecting ports
• CPC Class Codes: A61J 1/2062 with directional valves
• CPC Class Codes: A61J 1/2075 for external venting
• CPC Class Codes: A61J 1/2082 for gas filtration
• CPC Class Codes: A61J 1/2089 Containers or vials which are to be joined to each other in order to mix their contents combinations of vial and syringe for mixing their contents A61J1/2096
• CPC Class Codes: A61J 1/2093 Containers having several compartments for products to be mixed
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents
• CPC Class Codes: A61J 7/0053 Syringes, pipettes or oral dispensers
• CPC Class Codes: B65D 25/082 the partition being in the form of a plug or the like which is removed by increasing or decreasing the pressure within the container B65D81/3211 takes precedence

Abstract

The bottle (10) includes a narrowed neck (12) closed by a sealing body (29) provided with a radial channel (31) mounted on a capsule (32) sitting on said neck (12). The capsule (32) includes a connecting piece (34) protected by a cap (39). The bottle (10) is of the type with two compartments separated by an intermediate mobile stopper (18). The connecting piece (34) is conical and enables a Luer-lock type connection to be made with another bottle or with an apparatus for using the medicamental substance obtained after mixing the substances contained in the two compartments.

Claims

1. A double compartmented storage and transfer bottle for storing two components of a medicinal substance, namely a solid substance and a solvent, and for transferring said substance directly or after mixture with another substance to another container, said bottle comprising a tapered open neck and stopper means engaged in said neck for displacement between a first, storage, position in which the stopper means constitutes and impermeable stopper and a second, utility, position, characterized in that the stopper means capsule of a comprises a flexible elastomeric stopper defining a central cavity and a radial canal opening into the central cavity, a capsule mounted to the neck and axially displaceable between the storage position and the utility position, said stopper being mounted to said capsule, the capsule further including a connection device for connecting the bottle to a vessel, the bottle including a body defining first and second compartments, and a displaceable second stopper engaging said bottle body and providing a displaceable seat between said first and second compartments.

2. A bottle according to claim 1, characterized in that the capsule includes a conical connecting tip and a tightening element engaged inside the central cavity of the stopper.

3. A bottle according to claim 2, characterized in that the connecting tip is a tip of the "Luer" type.

4. A bottle according to claim 2, characterized in that the connecting tip is a tip of the "Luer Lock" type.

5. A bottle according to claim 2, characterized in that the connecting tip is a conical male tip.

6. A bottle according to claim 2, characterized in that the connecting tip is a conical female tip.

7. A bottle according to claim 1, characterized in that the capsule is connected to the bottle by a tamper-proof seal when said bottle is in the storage position.

8. A bottle according to claim 1, characterized in that the connection device comprises a needle.

9. A bottle according to claim 1, characterized in that the stopper means is comprised of a head and a annular gasket.

10. A bottle according to claim 9, characterized in that the head and the gasket are made of different materials.

11. A bottle according to claim 1 wherein said second stopper includes a cylindrical upper portion and an essentially elliptical lower portion.

12. A double compartmented storage and transfer bottle comprising:

a rigid upper compartment including a first neck portion;

a lower compartment;

a second neck portion or relatively small diameter connecting said upper compartment and said lower compartment;

a first stopper slidably mounted within said second neck portion;

a capsule slidably mounted to said first neck portion, said capsule including an upper end portion extending outside said first neck portion, a lower end portion positioned within said first neck portion, and a passage extending through said capsule between said upper end portion and said lower end portion;

said capsule further including a cylindrical protrusion extending within said first neck portion;

a second stopper secured to said cylindrical protrusion, said second stopper sealing one end of said passage when in a first axial position, said second stopper including a radial canal for allowing fluid communication between said upper compartment and said passage when in a second axial position,

a protective cap mounted to and substantially enclosing said capsule, said protective cap including an end portion adjoining an upper wall of said upper compartment for preventing downward movement of said cap, and

a removable, tamper-proof seal connected between said protective cap and said upper compartment.

13. A bottle as described in claim 12 wherein said capsule includes a needle removably mounted thereto.

14. A bottle as described in claim 12 wherein said stopper includes a radial passage sealed by said first neck portion.

15. A bottle as described in claim 12 wherein said first stopper includes a generally cylindrical upper portion of relatively large diameter and an elliptical lower portion of relatively small diameter.

16. A bottle as described in claim 12 including an O-ring seal positioned between said capsule and said first neck portion.

17. A bottle as described in claim 12 wherein said capsule includes a luer lock tip.

18. A double compartmented storage and transfer bottle for storing two components of a medicinal substance, namely a solid substance and a solvent, and for transferring said substance directly or after mixture with another substance to another container, said bottle comprising a tapered open neck and stopper means engaged in said neck for displacement between a first, storage, position in which the stopper means constitutes an impermeable stopper and a second, utility position, a connection device mounted to said neck for connecting the bottle to a vessel, said connection device including a needle;

a first compartment, a second compartment, and a second stopper separating said first compartment from said second compartment, and a passage defined within said connection device, said stopper means including means for providing fluid communication between said passage and said first compartment when said stopper means is in said second, utility position.