Polymer compound and coated particle composition
First Claim
1. A pharmaceutical composition for use in the parenteral delivery of a pharmaceutical compound, said composition comprisingparticles having a selected uniform size in a size range between 0.03-1.0 microns,each particle including (a) a single layer of linked polymer compounds composed of an outer hydrophilic polymer, an inner hydrophobic moiety, and a linking segment linking the polymer to the hydrophobic moiety and containing at least two chemical groups by which the compound can be crosslinked to at least two other compounds, (b) a crosslinked particle surface coated by said hydrophilic polymers, said crosslinked surface formed by a crosslinking structure created by crosslinks between said chemical groups, and (c) said pharmaceutical compound entrappod in said particle.
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Abstract
A composition of polymer-coated particles, and a polymer compound used in forming the particles are disclosed. The polymer compound is composed of a hydrophilic polymer attached to a lipophilic moiety through a linking segment which contains chemical groups through which the compound can be crosslinked to other such compounds. The particles in the composition are prepared by forming lipid structures containing ordered arrays of the polymer compounds, and crosslinking the compounds through their chemical groups. The particles are used for parenteral administration of a pharmaceutical compound which is entrapped in the particles.
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Citations
21 Claims
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1. A pharmaceutical composition for use in the parenteral delivery of a pharmaceutical compound, said composition comprising
particles having a selected uniform size in a size range between 0.03-1.0 microns, each particle including (a) a single layer of linked polymer compounds composed of an outer hydrophilic polymer, an inner hydrophobic moiety, and a linking segment linking the polymer to the hydrophobic moiety and containing at least two chemical groups by which the compound can be crosslinked to at least two other compounds, (b) a crosslinked particle surface coated by said hydrophilic polymers, said crosslinked surface formed by a crosslinking structure created by crosslinks between said chemical groups, and (c) said pharmaceutical compound entrappod in said particle.
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15. A method for preparing a pharmaceutical composition composed of particles having a selected uniform size between about 0.03-1.0 microns, for use in parentoral administration of a particle-entrapped pharmaceutical compound, said method comprising
(a) preparing, in an aqueous medium, lipid structures composed of a polymer compound having an outer hydrophilic polymer, an inner hydrophobic moiety, and a linking segment linking the polymer to the hydrophobic moiety and containing at least two chemical groups by which the compound can be crosslinked to at least two other compounds, and (b) crosslinking the chemical groups in the linking segments of the polymer compounds.
Specification