Device for the in vivo determination of an optical property of the aqueous humour of the eye

• US 5,535,743 A
• Filed: 12/17/1993
• Issued: 07/16/1996
• Est. Priority Date: 12/19/1992
• Status: Expired due to Term

• Current Assignee: Boehringer Mannheim GmbH (Roche Holding AG)
• Original Assignee: Boehringer Mannheim GmbH (Roche Holding AG)
• Inventors: Backhaus, Jurgen, Menzebach, Hans-Ulrich, Schrader, Bernhard, Schrader, Wolfgang, Bocker, Dirk, Schmidt, Elmar
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): GILBERT, SAMUEL G
• Application Number:
  US08/168,195
• Time in Patent Office: 942 Days
• Field of Search: 128/645, 128/664, 128/665, 128/632, 128/633, 606/2, 606/4, 606/13, 606/17, 606/18, 600/26-28, 356/39-42
• US Class Current: 600/310
• CPC Class Codes: A61B 3/10 Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
• CPC Class Codes: A61B 5/14558 by polarisation

Abstract

A device for the in vivo determination of an optical property of the aqueous humor in the anterior chamber of the eye includes a light source to irradiate light along a primary-side light path into the anterior chamber of an eye. A detector is provided, in order to detect light issuing from the anterior chamber along a secondary-side light path. A signal processing unit is provided to determine the optical properties on the basis of the measured signal of the detector. A routine in vivo examination of the aqueous humor of the eye, with minor inconvenience to the patient, can be achieved due to the fact that the device can be easily positioned in front of the eye. The central rays of the primary-side light path and of the secondary-side light path form, with the normals to surface of the cornea bordering the anterior chamber, an angle (α, β) such that the detector detects light reflected from the front interface of the eye lens.

Claims

1. An apparatus for in vivo determination of an optical property of an aqueous humour in an anterior chamber of a patient'"'"'s eye, said apparatus comprising:

an optical unit;

a light source fixed to said optical unit for irradiating light along a primary-side light path into the anterior chamber, said primary-side light path having a central ray;

a detector fixed to said optical unit for detecting light originating from said light source and issuing from said anterior chamber along a secondary-side light path, and generating a measured signal representative of detected light, said secondary-side light path having a central ray; and

signal processing means coupled to said detector, said signal processing means for determining optical properties of the aqueous humor based upon said measured signal,

wherein said optical unit is configured to be positioned in front of the patient'"'"'s eye, such that said optical unit directs said primary side light path to a partial area of a front interface of a lens of the eye and said central rays of said primary-side light path and said secondary-side light path are disposed to be at equal and opposite angles from a normal to the front interface of the lens whereby specular reflection from the interface is detected by the detector.

2. An apparatus as recited in claim 1, wherein said optical unit further directs said primary side light path to the partial area of the front interface in a vicinity of an optical axis of the eye in front of a pupil of the patient'"'"'s eye.

3. An apparatus as recited in claim 2, further comprising an optical imaging system disposed in said secondary-side light path, said optical imaging system generating an image of the interface on the detector.

4. An apparatus as recited in claim 3, wherein said optical imaging system comprises restriction means adapted to be disposed between the patient'"'"'s eye and said detector, for restricting specularly reflected light of said secondary-side light path to a predetermined portion of the interface.

5. An apparatus as recited in claim 4, wherein means are provided for restricting the primary side light path to selectively illuminate the predetermined portion of the interface to which the secondary-side light path is limited.

6. An apparatus as recited in claim 1, further comprising face mask means having said light source and said detector incorporated therein, said face mask means for individually fitting the apparatus to a face of a patient, said face mask means including means to locate the light source and the detector in a defined position with respect to the patient'"'"'s eye.

7. An apparatus as recited in claim 1, wherein said signal processing means determines optical rotation based upon the measured signal of the detector.

8. An apparatus as recited in claim 7, wherein said light irradiated from said light source into the anterior chamber has a wavelength between 290 nm and 400 nm.

9. An apparatus as recited in claim 1, wherein an optical property determined by the signal processing means is optical absorption.

10. An apparatus as recited in claim 9, wherein said optical absorption is optical absorption in a near infrared range.

11. An apparatus as recited in claim 1, wherein said optical properties determined by said signal processing means are optical rotation and optical absorption.

12. A method for in vivo determination of an optical property of an aqueous humour in an anterior chamber of a patient'"'"'s eye, said method comprising the steps of:

providing a light source and a detector, said light source providing a primary-side light path having a central beam;

positioning said light source and said detector in front of the patient'"'"'s eye, wherein the central beam of the primary-side light path and a central beam of a secondary-side light path each form an acute angle with respect to a respective normal to a surface of a cornea of the eye;

irradiating light from the light source along the primary-side light path into the anterior chamber of the eye;

detecting light originating from said light source and issuing from said anterior chamber along the secondary-side light path;

generating a measuring signal representative of said detected light;

determining optical properties based upon said measured signal,

wherein said detected light is reflected from a front interface of a lens of the eye.