Hemofiltration and plasmafiltration devices and methods
First Claim
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1. A filtration process for removing blood toxins, comprising:
- passing a fluid containing protein bound and/or middle molecular weight blood toxins through the interior of a hollow fiber membrane;
during said passing, circulating a sorbent suspension against exterior surfaces of the hollow fiber membrane;
during said passing and circulating, applying intermittent pulses of positive pressure to said sorbent suspension so that the fluid or a fraction thereof alternately exits and re-enters the interior of the hollow fiber membrane, wherein said fluid or fraction which exits the interior of the hollow fiber membrane contains the protein bound and/or middle molecular weight toxins which contact said sorbent suspension so as to effectuate removal of said toxins from said fluid and delivery of said toxins into said sorbent suspension.
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Accused Products
Abstract
Disclosed are preferred devices and methods which provide extracorporeal treatment of blood or other fluids for effective plasmafiltration or hemofiltration alone or in combination with dialysis.
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Citations
10 Claims
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1. A filtration process for removing blood toxins, comprising:
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passing a fluid containing protein bound and/or middle molecular weight blood toxins through the interior of a hollow fiber membrane; during said passing, circulating a sorbent suspension against exterior surfaces of the hollow fiber membrane; during said passing and circulating, applying intermittent pulses of positive pressure to said sorbent suspension so that the fluid or a fraction thereof alternately exits and re-enters the interior of the hollow fiber membrane, wherein said fluid or fraction which exits the interior of the hollow fiber membrane contains the protein bound and/or middle molecular weight toxins which contact said sorbent suspension so as to effectuate removal of said toxins from said fluid and delivery of said toxins into said sorbent suspension. - View Dependent Claims (2, 3, 4, 5)
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6. A blood dialysis device which comprises:
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a hollow fiber membrane; a pump fluidly connected to the interior of said hollow fiber membrane and adapted to pass a fluid containing middle molecular weight and/or protein-bound blood toxins through the interior of said hollow fiber membrane; a chamber surrounding said hollow fiber membrane, said chamber further being fluidly connected to a supply of sorbent suspension; a pump adapted to circulate said sorbent suspension through said chamber and against exterior surfaces of said hollow fiber membrane; and means for causing said fluid or fractions thereof passing through the interior of the follow fiber membrane to alternately exit and re-enter said interior. - View Dependent Claims (7, 8, 9, 10)
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Specification