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Controlled, sustained release delivery system for smoking cessation

  • US 5,536,503 A
  • Filed: 04/03/1995
  • Issued: 07/16/1996
  • Est. Priority Date: 05/07/1991
  • Status: Expired due to Fees
First Claim
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1. A transdermal drug delivery device comprising:

  • (a) a diffusion matrix layer, said diffusion matrix layer having a macroporous structure for holding a mixture of lobeline and an enhancer, and having a inner surface and an outer surface, said inner surface adapted to be applied on or toward the skin of a subject, said outer surface for application away from the skin of a subject,(b) a mixture of lobeline, a polymer and an enhancer, said mixture having a quantity of lobeline sufficient for delivery of an effective dose of lobeline to said subject to diminish said subject'"'"'s desire for nicotine, said enhancer controlling the solubility of said lobeline in said polymer to release said lobeline in said polymer over time to allow lobeline to be absorbed from said polymer by said skin; and

    (c) a backing layer, said backing layer comprising a film of elastomer on said outer surface of said diffusion matrix layer to prevent said mixture from being transmitted from the device, said diffusion matrix layer releasing an effective amount of lobeline to diminish said subject'"'"'s desire for nicotine for a period of at least one day.

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