Centrifugation system with a rotatable multi-element carrier

• US 5,538,493 A
• Filed: 12/14/1993
• Issued: 07/23/1996
• Est. Priority Date: 12/16/1992
• Status: Expired due to Term

• Current Assignee: Eppendorf AG
• Original Assignee: Eppendorf-Netheler-Hinz GmbH
• Inventors: Bouchain, Dieter, Gerken, Hero
• Primary Examiner(s): Cooley, Charles E.
• Application Number:
  US08/166,759
• Time in Patent Office: 952 Days
• Field of Search: 494/10, 494/16, 494/20, 494/21, 494/31, 494/33, 494/43, 494/85, 422/72
• US Class Current: 494/16
• CPC Class Codes: B04B 2005/0435 with adapters for centrifuge tubes or bags
• CPC Class Codes: B04B 5/0414 comprising test tubes
• CPC Class Codes: G01N 35/021 having a flexible chain, e.g. "cartridge belt", conveyor for reaction cells or cuvettes

Abstract

A system for centrifugation of samples includes at least one carrier, which is provided with a plurality of elements connected with each other by joints and having each an uptake for receiving a sample to be centrifuged, and a rotor for supporting the carrier, with the elements being arranged, in a centrifuged position of the elements, along a circle having its center lying on the rotational axis of the rotor.

Claims

1. A system for centrifugation of samples, comprising:

a carrier provided with a plurality of elements having each an uptake for receiving a sample to be centrifuged;

a rotor for supporting said carrier; and

joint means for connecting said plurality of elements with each other;

wherein said elements are arranged, in a centrifuged position of said carrier, along a circle, which has a center located on a rotational axis of said rotor;

wherein said elements have each first and second bearing surfaces for engaging respective bearing surfaces of the elements of adjacent carriers; and

wherein said first and second bearing surfaces are provided with complementary gaps and projections, respectively, for insuring a reliable connection of corresponding elements of the adjacent carriers.

2. A system for centrifugation of samples, comprising:

a carrier provided with a plurality of elements having each an uptake for receiving a sample to be centrifuged;

a rotor for supporting said carrier; and

joint means for connecting said plurality of carriers with each other;

wherein said elements are arranged, in a centrifuged position of said carrier, along a circle, which has a center located on a rotational axis of said rotor; and

wherein said joint means comprises strap hinges for connecting the adjacent elements and joining elements each having two parts for anchoring in the adjacent elements.

3. A system for centrifugation of samples, comprising:

a carrier provided with a plurality of elements having each an uptake for receiving a sample to be centrifuged;

a rotor for supporting said carrier; and

joint means for connecting said plurality of elements with each other;

wherein said elements are arranged, in a centrifuged position of said carrier, along a circle, which has a center located on a rotational axis of said rotor; and

wherein said joint means comprises strap hinges for connecting adjacent elements.

4. A system according to claim 3, wherein said elements have first surfaces, to provide for vertical alignment of said elements, and second surfaces, which extend at an angle to said first surfaces to provide for alignment of said elements when they extend at an angle to a vertical.

5. A system according to claim 3, wherein said elements further have stop means for limiting a slewing movement of said elements relative to each other.

6. A system according to claim 3, wherein each uptake has an upper charging hole for receiving a sample receptacle, and guide means for guiding a cover of the sample receptacle to provide for substantially exact alignment of the sample receptacles in the carrier.

7. A system according to claim 6, wherein each uptake has a length, which is less than a length of the sample receptacle received therein, and a bottom opening through which a bottom end of the sample receptacle projects.

8. A system according to claim 6, wherein each uptake completely surrounds the sample receptacle received therein.

9. A system according to claim 3, wherein said elements have transparent portions for enabling optical control of the centrifuged samples.

10. A system according to claim 3, wherein said carrier is formed as a unitary block of said elements, and wherein said elements each have a hole defining an uptake.

11. A system according to claim 3, wherein said elements have a plate-like shape, and said uptakes are formed by tubes.

12. A system according to claim 3, wherein said joint means comprises joining elements each having two parts for anchoring in two adjacent two elements, respectively.

13. A system according to claim 3, wherein said carrier is formed as one piece.

14. A system according to claim 3, further comprising means for stabilizing said elements in a predetermined position thereof.

15. A system according to claim 3, wherein said system comprises means for connecting said carrier to said rotor.

16. A system according to claim 3, comprising a plurality of carriers uniformly distributed over an area of said rotor.

17. A system according to claims 3, wherein said rotor has a contact surface for supporting said carrier in the centrifuged position of said carrier, and at least one radial support for said carrier.

18. A system according to claim 3, comprising at least one of an axial guide, a radial guide, and a tangential guide for transferring said carrier relative to said rotor.

19. A system according to claim 3, comprising a plurality of carriers which are arranged, at least in one of storing, transporting and treatment positions thereof, along a straight line parallel to each other.

20. A system according to claim 3, comprising a plurality of carriers which are arranged, at least in one of storing, transporting and treatment position thereof, parallel to each other.

21. A system according to claim 3, further comprising means arranged in a moving path of said carrier for treating samples.

22. A system according to claim 3, further comprising cover closing means provided in a moving path of said carrier for sample receptacles received in the uptakes of said elements.

23. A system according to claim 3, wherein said elements, have:

first surfaces to provide for alignment of said elements at a first angle; and

second surfaces to provide for alignment of said elements at a second angle.

24. A system according to claim 3, wherein said joint means comprises a plurality of joints having respective axes extending parallel to each other, and wherein said elements extend at an angle to the axes, and wherein said uptakes are located closest to the center of said circle in the angularly extending position of said elements.