Method of identifying tissue

• US 5,539,207 A
• Filed: 07/19/1994
• Issued: 07/23/1996
• Est. Priority Date: 07/19/1994
• Status: Expired due to Fees

• Current Assignee: National Research Council Canada
• Original Assignee: National Research Council Canada
• Inventors: Wong, Patrick T. T.
• Primary Examiner(s): Hannaher, Constantine
• Application Number:
  US08/277,086
• Time in Patent Office: 735 Days
• Field of Search: 250/339.09, 250/339.12, 250/339.08, 250/339.07
• US Class Current: 250/339.08
• CPC Class Codes: G01N 2021/3595 using FTIR
• CPC Class Codes: G01N 21/35 using infrared light G01N21/39 takes precedence

Abstract

A method of identifying tissue involves determining the infrared spectrum of a tissue sample in at least one frequency band, and comparing the infrared spectrum of the sample with a library of stored infrared spectra of known tissue types to find the closest match.

Claims

1. A method of identifying tissue comprising the steps of determining the infrared spectrum of a tissue sample over a range of frequencies in at least one frequency band, and comparing the infrared spectrum of said sample with a library of stored infrared spectra of known tissue types by visual comparison or using pattern recognition techniques to find the closest match.

2. A method as claimed in claim 1, wherein said infrared spectra are determined by FT-IR spectroscopy.

3. A method as claimed in claim 1, wherein said infrared spectroscopy is carried out under pressure, and said infrared spectra include the pressure dependence thereof.

4. A method as claimed in claim 1, wherein said known tissue types are selected from the group consisting of:

the colon epithelium, lamina propria, the cervical epithelium, and cervical connective tissue.

5. A method as claimed in claim 1, wherein the infrared spectra of said known tissue types are stored in a memory.

6. A method as claimed in claim 1, wherein said tissue is human tissue.

7. A method of identifying non-malignant tissue, comprising the steps of determining the infrared spectrum of a tissue sample over a range of frequencies in at least one frequency band;

comparing said infrared spectrum with a library of infrared spectra of known normal tissue types by visual comparison or using pattern recognition techniques; and

identifying the sample as non-malignant if it substantially matches one of said know tissue types.

8. A method as claimed in claim 7, wherein said infrared spectra are determined by FT-IR spectroscopy.

9. A method as claimed in claim 7, wherein said infrared spectroscopy is carried out under pressure, and said infrared spectra include the pressure dependence thereof.

10. A method as claimed in claim 7, wherein said tissue is human tissue.

11. An apparatus for identifying tissue comprising:

a) a first memory for storing the infrared spectra of a plurality of known tissue types in at least one frequency band;

b) an infrared spectrometer for determining the infrared spectrum of a tissue sample over a range of frequencies in at least one frequency band;

c) a second memory for storing said infrared spectrum of said tissue sample;

d) a processor for comparing the infrared spectra stored in said first and second memories using pattern recognition techniques to find the closest match; and

e) a display device for displaying the results of said comparison to permit identification of said sample tissue.

12. An apparatus as claimed in claim 11, wherein said infrared spectrometer is an FT-IR spectrometer.

13. An apparatus as claimed in claim 11, wherein said infrared spectrometer is a pressure spectrometer, and the pressure dependence of said infrared spectra of said known tissue types are also stored in said first memory.