Method and system for measuring the diffusion tensor and for diffusion tensor imaging

• US 5,539,310 A
• Filed: 08/07/1995
• Issued: 07/23/1996
• Est. Priority Date: 08/06/1993
• Status: Expired due to Term

• Current Assignee: United States Department Of Health And Human Services (Government of the United States of America)
• Original Assignee: United States Department Of Health And Human Services (Government of the United States of America)
• Inventors: Mattiello, James H., Basser, Peter J., LeBihan, Denis
• Primary Examiner(s): O'Shea, Sandra L.
• Assistant Examiner(s): Mah, Raymond
• Application Number:
  US08/511,920
• Time in Patent Office: 351 Days
• Field of Search: 324/309, 324/307, 324/300, 324/314, 324/315, 324/312, 324/313, 324/318, 324/322, 128/653.2
• US Class Current: 324/307
• CPC Class Codes: G01R 33/56341 Diffusion imaging

Abstract

A method and system for measuring the effective diffusion tensor for spin labeled particles, and generating images therefrom. The effective diffusion tensor is related to the echo intensity in an NMR spin-echo experiment. This relationship is used to design experiments from which the diffusion tensor components are estimated. Estimation of Deff provides the theoretical basis for a new MRI modality, diffusion tensor imaging. Diffusion ellipsoids may be used for generating images representative of physical characteristics of the observed object. Scalar invariants of the diffusion tensor are also used for imaging.

Claims

1. A magnetic resonance spectroscopy system comprising:

means for applying a static magnetic field to an object under examination;

means for applying gradient magnetic fields to the object;

means for applying a high frequency pulse to the object;

detecting means for detecting a magnetic resonance signal from the object;

control means for causing said means for applying gradient magnetic fields, and means for applying a high frequency pulse to operate in a predetermined sequence so as to induce magnetic resonance within the object, wherein said control means includes means for generating a plurality of echo signals corresponding to non-collinearly dependent directions of said gradient magnetic fields; and

means for processing data based on the magnetic resonance signal detected by said detecting means to obtain magnetic resonance information, wherein said means for processing data provides a signal that is a function of the components of a diffusion tensor representing translational displacement of spin labeled species for said object on the basis of said plurality of echo signals according to a predetermined relationship between said echoes and said components.

2. The system according to claim 1, wherein said predetermined sequence includes an imaging pulse sequence which induces said plurality of echo signals such that said means for processing data obtains the components of a plurality of said diffusion tensors corresponding to a respective plurality of regions of said object.

3. The system according to claim 2, wherein said means for data processing generates an image constructed from said components of said diffusion tensor.

4. The system according to claim 3, wherein said image is based on the eigenvectors and eigenvalues of said diffusion tensor.

5. The system according to claim 3, wherein said image is constructed from diffusion ellipsoids.

6. The system according to claim 3, wherein said image is constructed from functions of scalar invariants of said plurality of diffusion tensors.

7. The system according to claim 1, wherein said predetermined sequence generates said plurality of echo signals for a localized region of said object.

8. The system according to claim 1, further comprising means for calibrating said gradient magnetic fields.

9. The system according to claim 1, further comprising an image reconstruction means for obtaining an image based on said components of the diffusion tensor.

10. The system according to claim 1, further comprising a means for adjusting the orientation and field strength of said gradient magnetic fields based on measurement of said diffusion tensor for said object under examination, wherein said diffusion tensor is known.

11. The system according to claim 10, wherein said object under examination is characterized by isotropic diffusion, and thereby has a diagonal diffusion tensor.

12. A method for estimating at least one component of a diffusion tensor representing translational displacement of spin labeled species for a sample inserted in an NMR apparatus comprising the steps of:

deriving a relationship between an NMR signal and said diffusion tensor;

generating a pulse sequence in said NMR apparatus for generating said NMR signal;

calculating said at least one component of said diffusion tensor based on said NMR signal, according to said relationship.

13. The method according to claim 12, wherein said pulse sequence includes an imaging pulse sequence for generating a signal used for constructing a diffusion weighted image.

14. The method according to claim 12, wherein said pulse sequence includes an imaging pulse sequence which induces a plurality of said NMR signals such that said components of a plurality of said diffusion tensors, corresponding to a respective plurality of regions of said object, may be calculated in said calculating step.

15. The method according to claim 14, further comprising the step of generating images based on information contained in said said diffusion tensor.

16. A method for estimating at least one component of a diffusion tensor representing translational displacement of spin labeled species for a localized region of a sample comprising the steps of:

immersing the sample in a static magnetic field;

exciting nuclear magnetic resonance echoes in said sample by application of a predetermined pulse sequence;

calculating said at least one component of said diffusion tensor based on said echoes, according to a predetermined relationship between said echoes and said components.

17. The method according to claim 16, further comprising the step of generating images based on information contained in said said diffusion tensor.

18. A method for estimating at least one component of a diffusion tensor representing translational displacement of spin labeled species for a sample inserted in a resonance apparatus, said resonance apparatus having means for inducing a signal in said sample, including means for generating gradient magnetic fields in non-linearly dependent directions, means for applying a static magnetic field, means for generating high frequency pulses, and means for receiving said signal, comprising the steps of:

deriving a relationship between said signal and said diffusion tensor;

generating a pulse sequence in said resonance apparatus for generating said signal;

calculating said at least one component of said diffusion tensor based on said signal, according to said relationship.

19. The method according to claim 18, further comprising the step of adjusting said gradient magnetic fields based on said diffusion tensor for said sample, wherein said diffusion tensor is known.

20. A NMR apparatus comprising:

means for generating an echo signal in said sample; and

means for processing said echo signal into a signal that is a function of a diffusion tensor representing translational displacement of spin labeled species for said sample.

21. The NMR apparatus of claim 20, wherein said echo signal is a spin echo signal.

22. The NMR apparatus of claim 20, wherein said echo signal is generated in a voxel.

23. The NMR apparatus of claim 22, further comprising means for combining echo signal from a plurality of voxels of said sample.

24. The NMR apparatus of claim 20, said NMR apparatus having means for generating orthogonal gradient fields and means for applying a static magnetic field, said apparatus further comprising means for aligning and calibrating said orthogonal gradient fields according to the signal representative of the diffusion tensor.

25. A method for measuring NMR of a sample inserted into a NMR apparatus, comprising the steps of:

generating an echo signal in said sample; and

processing said echo signal into a signal that is a function of a diffusion tensor representing translational displacement of spin labeled species for said sample.

26. The method according to claim 25, wherein said signal includes at least one component of said diffusion tensor.

27. The method according to claim 25, wherein said signal includes a diffusion constant of said diffusion tensor.

28. The method according to claim 25, wherein said diffusion tensor includes two spatial dimensions.

29. The method according to claim 25, wherein said NMR apparatus includes means for generating orthogonal gradient fields and means for applying a static magnetic field, said method further comprising the step of aligning and calibrating said orthogonal gradient fields according to the signal representative of a diffusion tensor.

30. The method according to claim 25, wherein said signal includes a function of a trace of said diffusion tensor.

31. The method according to claim 25, wherein said signal includes a signal related to an eigenvector of said diffusion tensor.

32. The method according to claim 25, wherein said signal includes a function of an eigenvalue of said diffusion tensor.

33. A method for measuring NMR of a sample inserted into a NMR apparatus, said method comprising the steps of:

generating an echo signal in said sample, said echo signal encoded according to the diffusion tensor of said spatially translating component; and

processing said echo signal into a signal representative of a diffusion tensor representing translational displacement of spin labeled species for said sample.

34. The method according to claim 33, wherein said echo signal is generated within a localized region of said sample.

35. The method according to claim 33, wherein said step of generating an echo signal includes the step of applying a pulse sequence for driving magnetic field gradients of said NMR apparatus such that said echo signal represents a combination of different elements of the diffusion tensor.