Cranial nerve stimulation treatments using neurocybernetic prosthesis

• US 5,540,734 A
• Filed: 09/28/1994
• Issued: 07/30/1996
• Est. Priority Date: 09/28/1994
• Status: Expired due to Term

• Current Assignee: Jacob Zabara
• Original Assignee: Jacob Zabara
• Inventors: Zabara, Jacob
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): Jastrzab, Jeffrey R.
• Application Number:
  US08/314,173
• Time in Patent Office: 671 Days
• Field of Search: 607/44-48, 607/58, 607/62, 607/70, 607/72, 607/116, 607/118, 600/26
• US Class Current: 607/46
• CPC Class Codes: A61N 1/36025 for treating a mental or cerebral condition
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36167 Timing, e.g. stimulation onset
• CPC Class Codes: A61N 1/36196 Frequency modulation
• CPC Class Codes: A61N 1/372 Arrangements in connection with the implantation of stimulators

Abstract

The treatment, control or prevention of medical, psychiatric or neurological disorders may be accomplished by application of modulating electric signals to one or both of a patient'"'"'s trigeminal and glossopharyngeal nerves. The disorders treatable, controllable or preventable by such nerve stimulation include voluntary and involuntary disorders, migraine, epileptic seizure, motor disorders, Parkinson'"'"'s disease, cerebral palsy, spasticity, chronic nervous illnesses and involuntary movement; pancreatic endocrine disorders including diabetes and hypoglycemia; dementia including cortical, subcortical, multi-infarct, Alzheimer'"'"'s disease and Pick'"'"'s disease; sleep disorders including central sleep apnea, insomnia and hypersomnia; eating disorders including anorexia nervosa, bulimia and compulsive overeating; and neuropsychiatric disorders including schizophrenia, depression and borderline personality disorder.

Claims

1. A method of treating, controlling or preventing medical, psychiatric or neurological disorders selected from the group consisting of motor disorders;

migraine;

chronic nervous illness;

pancreatic endocrine disorders including diabetes and hypoglycemia;

dementia including cortical, subcortical, multi-infarct, Alzheimer'"'"'s disease and Pick'"'"'s disease;

eating disorders including anorexia nervosa, bulimia, and compulsive overeating;

sleep disorders including insomnia, hypersomnia, narcolepsy and sleep apnea; and

neuropsychiatric disorders including schizophrenia, depression and borderline personality disorder, comprising the steps of attaching at least one electrode to afferents of at least one of a patient'"'"'s trigeminal and glossopharyngeal nerves, and applying modulating electric signals to at least one of the patient'"'"'s trigeminal and glossopharyngeal nerves through the at least one electrode.

2. The method according to claim 1 wherein the modulating electric signals have a frequency of about 5 to about 300 cycles per second at a constant current of between about 0.5 and about 20 milliamperes, and a pulse width of between about 0.1 and 1 millisecond.

3. The method according to claim 1, wherein patients experiencing symptoms of migraine are treated by a process comprising

a. detecting a physiological symptom associated with onset of a migraine attack in a patient under treatment, and

b. in response to detection of such symptom, selectively applying said modulating electric signals as a programmed electrical stimulus to at least one of the patient'"'"'s trigeminal and glossopharyngeal nerves, for modulating electrical activity of preselected fibers of said nerve, in a manner to alleviate the migraine attack.

4. The method according to claim 1, wherein patients experiencing symptoms of migraine are treated by a process comprising

a. providing an electrical stimulus generator with an electrical output signal having parameters which are programmable within predetermined ranges, and adapting the stimulus generator to generate its output signal upon selective activation of the stimulus generator,

b. implanting the stimulus generator in the patient'"'"'s body, and implanting a nerve electrode to receive the output signal of the stimulus generator on at least one of the trigeminal and glossopharyngeal nerves of the patient, and

c. programming at least some of the programmable parameters of the output signal of the stimulus generator according to the symptoms of the migraine suffered by the particular patient under treatment to modulate electrical activity of said nerve in a predetermined manner, upon activation of the stimulus generator and

d. applying said modulating electric signals as the programmed output signal to said nerve through the nerve electrode planted thereon, to alleviate symptoms of a migraine episode experienced by the patient.

5. The method according to claim 1 wherein the motor disorder is a seizure associated with epilepsy, Parkinson'"'"'s disease, cerebral palsy and chronic nervous illnesses, and wherein said electric signals are applied repeatedly over a period of time to thereby prevent or control such seizures.

6. The method according to claim 1 wherein involuntary movements due to epileptic seizures, cerebral palsy, Parkinson'"'"'s disease, and spasticity are controlled or prevented, further comprising the step of determining that an involuntary movement is going to occur and thereafter applying said modulating electric signals as a pulsed electrical signal to at least one of the trigeminal and glossopharyngeal nerves to thereby prevent such movement.

7. The method according to claim 1, comprising treating pancreatic endocrine disorders, diabetes and hypoglycemia including the steps of:

(a) detecting a blood glucose concentration indicative of an endocrine disorder in a patient, and

(b) in response to such detection, selectively applying said modulating electric signals to at least one of the patient'"'"'s trigeminal and glossopharyngeal nerves for modulation of electrical activity thereof, to adjust secretion of endogenous insulin and thereby control the endocrine disorder.

8. The method according to claim 1, comprising treating and controlling diabetes in a patient including the steps of:

(a) providing a programmable device responsive, when activated, to apply said modulating electric signals as a programmed electrical signal to at least one of the patient'"'"'s trigeminal and glossopharyngeal nerves for stimulation thereof to adjust secretion of endogenous insulin appropriate to maintain insulin-glucose homeostasis in the patient'"'"'s bloodstream and thereby control the diabetes, and

(b) periodically activating the device to maintain the homeostasis.

9. The method according to claim 1, comprising treatment of patients with dementia, including cortical dementia, subcortical dementia, multi-infarct dementia, Alzheimer'"'"'s disease, Pick'"'"'s disease and vascular dementia, including the steps of:

(a) selecting a patient suffering from dementia, and

(b) applying said modulating electric signals with predetermined electrical parameters to at least one of the patient'"'"'s trigeminal and glossopharyngeal nerves to selectively modulate electrical activity of preselected afferent fibers of said nerve distributed to a reticular activating system in a patient'"'"'s brain stem and thereby modulate the electrical activity of preselected portions of the reticular activating system of the patient, to relieve a symptom of the dementia.

10. The method according to claim 1 comprising treating and controlling the symptoms of dementia, including cortical dementia, subcortical dementia, multi-infarct dementia, Alzheimer'"'"'s disease, Pick'"'"'s disease and vascular dementia, in a patient, comprising the steps of:

(a) selecting a patient suffering from dementia,

(b) implanting an electrode on at least one of the patient'"'"'s trigeminal and glossopharyngeal nerves for application of an electrical signal having predetermined electrical parameter values to the nerve accepting the implant, and

(c) delivering the modulating electrical signals to the implanted electrode to selectively modulate electrical activity of said nerve and thereby treat a symptom of the dementia exhibited by the patient.

11. The method according to claim 1, comprising the treatment of patients with an eating disorder, including anorexia nervosa, bulimia and compulsive overeating, by therapy which alleviates a symptom of the disorder and includes the steps of:

(a) detecting a preselected event indicative of an imminent need for treatment of a specific eating disorder, and

(b) responding to a detected occurrence of the preselected event by applying said modulating electric signals to at least one of the patient'"'"'s trigeminal and glossopharyngeal nerves appropriate to alleviate said symptom of the eating disorder.

12. The method according to claim 1, comprising treatment of patients with neuropsychiatric disorders, including schizophrenia, depression and borderline personality disorder, including

(a) determining symptoms of a neuropsychiatric disorder being exhibited by the patient,

(b) selectively applying said modulating electric signals to at least one of the patient'"'"'s trigeminal and glossopharyngeal nerves for modulating electrical activity thereof in a manner to alleviate symptoms of the neuropsychiatric disorder exhibited by the patient being treated.

13. The method according to claim 1, comprising treatment Of patients experiencing sleep disorders, which includes the step of:

(a) detecting a physiological event associated with the sleep disorder in the patient to be treated, and

(b) upon detection of such physiological event, applying said modulating electric signals to at least one of the patient'"'"'s trigeminal and glossopharyngeal nerves for modulating the electrical activity of said nerve to alleviate the sleep disorder under treatment.