Thromboresistant coating for defoaming applications

• US 5,541,167 A
• Filed: 10/28/1994
• Issued: 07/30/1996
• Est. Priority Date: 05/31/1991
• Status: Expired due to Term

• Current Assignee: Edwards Lifesciences Corporation
• Original Assignee: Baxter International Inc.
• Inventors: Loar, Mark E., Hsu, Li-Chien
• Primary Examiner(s): Robinson, Douglas W.
• Assistant Examiner(s): Fonda, Kathleen Kahler
• Application Number:
  US08/331,292
• Time in Patent Office: 641 Days
• Field of Search: 514/56, 536/21, 536/124, 536/55.3, 523/112, 604/4, 604/317
• US Class Current: 514/56
• CPC Class Codes: A61L 33/0011 Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate

Abstract

A composition for coating medical blood contacting surfaces comprises a mixture of an anticoagulant and a defoaming agent. The coating composition is applied by either dipping the device into a solution containing the mixture or by spraying the mixture onto the surface. Alternatively, the surface can be sequentially dip coated and/or sprayed with the individual components. In a preferred embodiment, the anticoagulant is a quaternary ammonium complex of heparin, preferably stearyldimethylbenzyl ammonium heparin, and the antifoaming agent is a mixture of polydimethylsiloxane and silicon dioxide.

Claims

1. An antithrombogenic defoaming medical device comprising a medical device having a surface which contacts blood mixed with air, said surface having applied thereto sequential coatings of a solution of an antithrombogenic heparin species and a defoaming liquid mixture of a polysiloxane and silicon dioxide.

2. The medical device of claim 1 wherein said medical device is an extracorporeal blood processing device.

3. The medical device of claim 1 wherein said heparin species is a quaternary ammonium complex of heparin.

4. The medical device of claim 1 wherein said polysiloxane is a polydimethyl siloxane.

5. The medical device of claim 1 wherein said heparin species is a member selected from the group consisting of acetyl ammonium heparin, stearyldimethylbenzyl ammonium heparin, benzalkonium heparin, and tridodecylmethyl ammonium heparin.

6. The medical device of claim 5 wherein said medical device is an extracorporeal blood processing device.

7. A method for providing an antithrombogenic defoaming blood contacting surface which comprises applying to a surface, which contacts blood mixed with air, sequential coatings of a solution of an antithrombogenic heparin species and a defoaming liquid mixture of a polysiloxane and silicon dioxide.

8. The method of claim 7 wherein said surface is a surface of an extracorporeal blood processing device.

9. The method of claim 7 wherein said heparin species is a quaternary ammonium complex of heparin.

10. The method of claim 7 wherein said heparin species is a member selected from the group consisting of acetyl ammonium heparin, stearyldimethylbenzyl ammonium heparin, benzalkonium heparin, and tridodecylmethyl ammonium heparin.

11. The method of claim 7 wherein said polysiloxane is a polydimethyl siloxane.

12. The method of claim 7 wherein said blood contacting surface is a surface of a medical device.

14. An antithrombogenic defoaming medical device prepared according to the method of claim 7.

13. A method for providing an antithrombogenic defoaming medical device which comprises the steps of:

(a) applying to a surface of a medical device, which contacts blood mixed with air, a liquid mixture of a polysiloxane and silicon dioxide, and

(b) applying a solution of a quaternary ammonium complex of heparin to the surface to which said liquid mixture has been applied.

15. An antithrombogenic defoaming medical device prepared according to the method of claim 13.