Method of and arrangement for optimizing and checking heart diagnosis

• US 5,542,429 A
• Filed: 08/03/1994
• Issued: 08/06/1996
• Est. Priority Date: 10/30/1989
• Status: Expired due to Term

• Current Assignee: Genquan Feng
• Original Assignee: Genquan Feng
• Inventors: Feng, Genquan
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US08/287,798
• Time in Patent Office: 734 Days
• Field of Search: 128/702-705
• US Class Current: 600/515
• CPC Class Codes: A61B 5/30 Input circuits therefor

Abstract

Heart/brain disease is non-invasively, accurately diagnosed at an early stage. A plurality of functions descriptive of the patient are mathematically determined. A set of indices for each function is established in advance. Each index has two states indicative of the patient'"'"'s condition. An integrated pattern of the states of the indices from a plurality of the functions is generated and matched against a stored collection of index patterns whose diagnosis is known. The diagnosis is optimized with the aid of weighting factors for such parameters as patient'"'"'s age and medical history. In addition, the diagnosis is also checked doctors'"'"' opinion.

Claims

1. A method of optimizing the diagnosis of a condition of a patient tested, comprising the steps of:

(a) acquiring electrocardiogram (analog signals) from the patient;

(b) mathematically determining a plurality of functions descriptive of the patient from the signals;

(c) establishing a set of indices for each function, each index having two states, each indicative of the condition of the patient;

(d) recognizing the state of each index for each function;

(e) generating an integrated pattern of the states of the indices from a plurality of the functions;

(f) storing a collection of index patterns, each containing a multitude of patterns of the states of indices for a multitude of patients whose condition is known;

(g) matching the generated integrated pattern against the stored collection of index patterns to obtain a plurality of raw scores;

(h) inputting the critical diagnostic factors, which effect the diagnosis of heart diseases, into the device;

(i) establishing a set of weights for each of the critical diagnostic factors which effect the diagnosis of heart diseases, according to the importance of such factors;

(j) weighting the raw scores to obtain weighted scores;

(k) inputting doctors'"'"' opinion about the diagnosis of the patient; and

(l) presenting an optimized diagnosis based on the weighted scores and doctors'"'"' opinion.

2. The method according to claim 1, wherein the acquiring step is performed by acquiring electrocardiographic signals as a function of time from a surface of the body of a patient being analyzed through a plurality of surface electrodes.

3. The method according to claim 2, wherein the acquiring step is performed by processing the electrocardiographic signals into two of the analog signals that is EKG leads V5 and standard II, and the test period being 100-200 seconds.

4. An arrangement for optimizing the diagnosis of a condition of a patient tested, comprising:

(a) means for acquiring electrocardiogram (analog signals) from the patient;

b) means for mathematically determining a plurality of functions descriptive of the patent from the signals;

(c) means for establishing a set of indices for each index having two states, each indicative of the condition of the patient;

(d) means for recognizing the state of each index for each function;

(e) means for generating an integrated pattern of the states of the indices from a plurality of the functions;

(f) means for storing a collection of index patterns, each containing a multitude of patterns of the states of indices for a multitude of patients whose condition is known;

(g) means for matching the generated integrated pattern against the stored collection of index patterns to obtain a plurality of raw scores;

(h) means for inputting the critical diagnostic factors, which effect the diagnosis of heart diseases, into the device;

(i) means for establishing a set of weights for each of;

the critical diagnostic factors which effect the diagnosis of heart diseases, according to the importance of such factors;

(j) means for weighting the raw scores to obtain weighted scores;

(k) inputting doctors'"'"' opinion about the diagnosis of the patient; and

(l) means for presenting an optimized diagnosis based on the weighted scores and doctors'"'"' opinion;

(m) said establishing means for defining indices including;

(I) Power Spectrum

(1) 1/2--Is the amplitude ratio of the first peak/second peak above a limit?

(2) O--Is shape of any of first four peaks rounded similar to omega (Ω

)?

(3) U1--Do any of first four peaks have a twinned peak?

(4) U2--Are the intervals between any of first four peaks unequal?

(5) U3--Is the inequality of the intervals between any of the first four peaks above a limit?

(6) U3_xy --Same as U3 but are any two peaks simultaneously positive?

(7) U4--Is the shape of any peak similar to a hill ()?

(8) U5--Is the shape of any peak similar to a mountain ()?

(9) N1--Is the first peak null?

(10) N3--is the third and/or fourth peak null?

(11) S--Is the heart rate below 60 beats per minute?

(12) SS--Is the heart rate below 50 beats per minute?

(13) F--Is the heart rate over 100 beats per minute?

(14) FF--Is the heart rate above 120 beats per minute?

(15) A1--Is the amplitude of the first peak above a limit?

(16) A2--is the amplitude of any two of the first four peaks above a limit?

(17) A3--Is the amplitude of the second peak above a limit?

(18) A4--Is the amplitude of the third and/or fourth peak above a limit?

(19) A5--is any one of the 5th-12th peaks higher than the first peak?

(20) A55--Are any two of the 5th-12th peaks higher than the first peak?

(21) A6--Are more than two of the 5th-12th peaks higher than the first peak?

(22) Nn--Are the first and second peaks higher than the third and fourth peaks?

(23) nN--Are the third and fourth peaks higher than the first and second peaks?

(24) Nnn--Is the first peak higher than the second, third and fourth peaks?

(25) nnN--Is the first peak lower than the second, third and fourth peaks?

(II) Phase Angle

(26) P+--Does the phase angle lag above a limit at various frequency bands?

(27) P--Does the phase angle lead above a limit at various frequency bands?

(28) WW--Is the shape of the waveform similar to the letter "W" at various frequency bands?

(29) PW+--Do indices 26 and 28 co-exist at various frequency bands?

(30) PW--Do indices 27 and 28 co-exist at various frequency bands?

(31) L--Is the phase angle too small plus is the impulse response too even?

(32) U--Does the waveform have the shape of the letter "U" at various frequency bands?

(33) W--Are there two or more U-shaped waves?

(34) V--Does the waveform have a long upward slope?

(35) Y--Is the slope of the waveform positive or negative?

(36) X--Do indices 32 and 35 or 32 and 33 co-exist?

(37) Z--Does the waveform have waves shaped like the letter "Z"?

(III) Impulse response

(38) D1--Does the waveform have a double top plane wave resembling or ?

(39) D2--Does the waveform have a stair steps wave resembling ?

(40) f--is the main response impulse negative?

(41) M1--Does the main response impulse have a twin peak?

(42) M2--Does the shape of the main response impulse resemble the letter "M"?

(43) M3--Does the main response impulse have more than three peaks?

(44) M4--Does the main response impulse have a peak that is too wide?

(45) M5--Does the side response have a peak whose amplitude is above a limit?

(46) M6--Is the main response impulse totally downward?

(IV) Coherence

(47) Q1--Is the coherence of the first peak of the power spectrum below a limit?

(48) Q2--Is the coherence of the highest peak of the transfer function below a limit?

(V) Ampulitude Histogram

(49) V+--Is the amplitude of lead V5 above a limit?

(50) 2+--Is the amplitude of lead II above a limit?

(51) V--is the amplitude of lead V5 below a limit?

(52) 2--Is the amplitude of lead II below a limit?

(53) Vn+--Is the number of bundles of the column in the amplitude histogram of lead V5 above a limit?

(54) Vn--Is the number of bundles of the column in the amplitude histogram of lead V5 below a limit?

(55) 2n+--Is the number of bundles of the column in the amplitude histogram of lead II above a limit?

(56) 2n--Is the number of bundkes of the column in the amplitude histogram of lead II below a limit?

(VT) Cross Correlation

(57) RRR--Is the amplitude of the main peak above a limit?

(58) rrr--Is the amplitude of the main peak below a limit?

(59) R--Is the main peak within a higher zone?

(60) r--Is the main peak within a lower zone?

(61) RR--Is the interval between R1 and R2 above a limit?

(62) rr--Is the interval between R1 and R2 too short?

(63) rR--Is the peak R1 lower than the peak R2?

(64) R2--Is the peak R2 below a limit?

(65) R+--Does the peak R1 shift to the right side?

(66) R---Does the peak R2 shift to the left side?

(67) Rw+--Is the bottom of the first positive peak below the bottom of the first negative peak, and so on for successive peaks?

(68) Rw--Is the bottom of the first positive peak above the bottom of the first negative peak, and so on for successive peaks?

(69) pt--Is the number of peaks whose amplitude is above a threshold between peaks R1 and R2 above a limit?

(70) PT--Is there one or more peaks between peaks R1 and R2 higher than peak R2 above a limit?

(71) Rn--Does R2 have a twin peak or a zigzag shape?

(72) Rm--Is the peak R1 too wide?

(73) Rv--Is one bend of R1 too steep in slope?