Iontophoretic delivery device and method of making same
First Claim
1. A method of making an electrode assembly for an electrically powered iontophoretic delivery device, comprising:
- homogeneously blending a mixture of about 5 to 50 vol % of a conductive filler, from about 1 to 50 vol % of a therapeutic agent to be iontophoretically delivered in order to obtain a therapeutic effect and the remainder a polymeric matrix; and
forming the agent-containing blended mixture into a sheet having a predetermined thickness, wherein the filler forms an electrically conductive network through the entire thickness of the matrix.
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Abstract
An electrically powered transdermal iontophoretic delivery device (10, 20) and a method of making same is provided. The device utilizes electrode assemblies (8, 9) composed of a substantially homogenous blend of a polymeric matrix containing about 5 to 50 vol % of a conductive filler which forms a conductive network through the matrix, and up to about 50 vol % of the agent to be iontophoretically delivered through the skin. In the case of the donor electrode assembly, the agent is typically a drug and preferably a water soluble drug salt. In the case of the counter electrode assembly, the agent is typically an electrolyte salt. The homogenous blend eliminates the need for separate electrode and agent containing layers which require lamination.
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Citations
19 Claims
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1. A method of making an electrode assembly for an electrically powered iontophoretic delivery device, comprising:
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homogeneously blending a mixture of about 5 to 50 vol % of a conductive filler, from about 1 to 50 vol % of a therapeutic agent to be iontophoretically delivered in order to obtain a therapeutic effect and the remainder a polymeric matrix; and forming the agent-containing blended mixture into a sheet having a predetermined thickness, wherein the filler forms an electrically conductive network through the entire thickness of the matrix. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification