Intermittent use of bright light to modify the circadian phase

• US 5,545,192 A
• Filed: 11/28/1994
• Issued: 08/13/1996
• Est. Priority Date: 06/26/1987
• Status: Expired due to Term

• Current Assignee: Brigham and Women's Hospital Incorporated
• Original Assignee: Brigham and Women's Hospital Incorporated
• Inventors: Czeisler, Charles A., Kronauer, Richard E.
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US08/348,257
• Time in Patent Office: 624 Days
• Field of Search: 607/88
• US Class Current: 607/88
• CPC Class Codes: A61M 2021/0044 by the sight sense
• CPC Class Codes: A61M 21/00 Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
• CPC Class Codes: A61N 2005/0648 the light being directed to the eyes
• CPC Class Codes: A61N 5/0618 Psychological treatment

Abstract

The present invention is a method for modifying the circadian cycle of a human subject to a desired state including the steps of determining the characteristics of the desired circadian cycle, selecting an appropriate time during which to apply a light stimulus to effect a desired modification of the present circadian cycle, and applying the stimulus at the selected time to achieve the desired circadian cycle for the subject. The light stimulus of the present invention includes an episode of intermittent light consisting of at least two pulses of enhanced light separated by at least one pulse of reduced light.

Claims

1. A method of modifying a human subject'"'"'s endogenous circadian cycle to a desired state, comprising the steps of:

determining the characteristics of a desired endogenous circadian cycle for said subject;

selecting an appropriate time with respect to the presumed phase of physiological markers of the subject'"'"'s present endogenous circadian cycle during which to apply a light stimulus to effect a desired modification of said present endogenous circadian cycle of said subject, wherein said stimulus comprises an episode of intermittent light consisting of at least two pulses of light of enhanced intensity separated by at least one pulse of light of reduced intensity and

applying said stimulus at said selected appropriate time to achieve said desired endogenous circadian cycle for said subject.

2. The method of claim 1, wherein at least one of said pulses of light of enhanced intensity has an intensity greater than approximately 4,000 lux.

3. The method of claim 1, wherein at least one of said pulses of light of enhanced intensity has an intensity between approximately 500-1,000 lux.

4. The method of claim 1, wherein at least one of said pulses of light of enhanced intensity has an intensity between approximately 1,000-2,000 lux.

5. The method of claim 1, wherein at least one of said pulses of light of enhanced intensity has an intensity between approximately 2,000-4,000 lux.

6. The method of claim 1, wherein at least one of said pulses of light of enhanced intensity has an intensity between approximately 4,000-100,000 lux.

7. The method of claim 1, wherein at least one of said pulses of light of reduced intensity has an intensity between approximately 0-200 lux.

8. The method of claim 7, wherein at least one of said pulses of light of reduced intensity has an intensity between approximately 0-10 lux.

9. The method of claim 7, wherein at least one of said pulses of light of reduced intensity has an intensity between approximately 10-50 lux.

10. The method of claim 7, wherein at least one of said pulses of light of reduced intensity has an intensity between approximately 50-200 lux.

11. The method of claim 1, wherein approximately 20% of the duration of said episode of intermittent light comprises light of enhanced intensity.

12. The method of claim 11, wherein said episode of intermittent light comprises an approximately 5 hour episode of approximately 25 minute cycles, each 25 minute cycle including approximately a 1 minute transition up to light of enhanced intensity, four minutes of enhanced light, a 1 minute transition down to light of reduced intensity, and 19 minutes of light of reduced intensity.

13. The method of claim 1, wherein greater than approximately 20% of the duration of said episode of intermittent light comprises light of enhanced intensity.