Interstitial heating of tissue

• US 5,545,195 A
• Filed: 08/01/1994
• Issued: 08/13/1996
• Est. Priority Date: 08/01/1994
• Status: Expired due to Term

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Corporation
• Inventors: Lennox, Charles D., Roberts, Troy W.
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US08/283,986
• Time in Patent Office: 743 Days
• Field of Search: 604/113, 604/114, 606/27, 606/28, 606/29, 606/30, 606/31, 607/96, 607/98, 607/99, 607/113, 607/105
• US Class Current: 607/105
• CPC Class Codes: A61B 17/3415 for introducing tubes or catheters, e.g. gastrostomy tubes, drain catheters A61B17/3417 takes precedence; body piercing catheter guide needles A61M25/06
• CPC Class Codes: A61B 18/082 Probes or electrodes therefor
• CPC Class Codes: A61B 2017/22062 to be filled with liquid
• CPC Class Codes: A61F 2007/126 for invasive application, e.g. for introducing into blood vessels
• CPC Class Codes: A61F 7/123 using a flexible balloon containing the thermal element
• CPC Class Codes: G01R 33/285 Invasive instruments, e.g. catheters or biopsy needles, specially adapted for tracking, guiding or visualization by NMR

Abstract

An elongated, rigid implement having a sharp distal end is insertable into a solid mass within the body of a living being through a puncture site in the solid mass created by the sharp distal end. An elongated sleeve, which engages the elongated, rigid implement, is insertable into the solid mass through the puncture site in the solid mass. Fluid is provided to an expandable chamber located in the vicinity of a distal end of the elongated sleeve through at least one channel located within the elongated sleeve, to inflate the chamber while the chamber is positioned interstitially within the solid mass. A heating device located within the expandable chamber is powered, through at least one elongated conductor located within the elongated sleeve, to heat fluid within the chamber while the chamber is filled with the fluid and is positioned interstitially within the solid mass. The inflation of the chamber while the chamber is positioned interstitially within the solid mass causes compressive ischemia of tissue surrounding the chamber, and the compressive ischemia of the tissue surrounding the chamber reduces a heat sink effect of the tissue during powering of the heating device.

Claims

1. A medical system for interstitial heating of a solid mass within a body of a living being, comprising:

an elongated, rigid implement having a sharp distal end and constructed for insertion into said solid mass through a puncture site in said solid mass created by said sharp distal end,

an elongated sleeve constructed to engage said elongated, rigid implement and constructed to enter said solid mass through said puncture site in said solid mass and to extend into said solid mass,

an expandable chamber located in the vicinity of a distal end of said elongated sleeve,

at least one channel located within said elongated sleeve to provide a fluid to said expandable chamber for inflation of said chamber while said chamber is positioned interstitially within said solid mass,

a heating device located within said expandable chamber for heating said fluid within said chamber while said chamber is filled with said fluid, and

at least one elongated conductor located within said elongated sleeve and connected to said heating device to power said heating device while said chamber is positioned interstitially within said solid mass and is filled with said fluid.

2. A medical system in accordance with claim 1 wherein said elongated, rigid implement comprises a needle.

3. A medical system in accordance with claim 1 wherein said elongated rigid implement comprises a trocar.

4. A medical system in accordance with claim 1 wherein said elongated rigid implement and said elongated sleeve are separate and distinct elements.

5. A medical system in accordance with claim 1 wherein said elongated sleeve is mounted directly on said elongated rigid implement.

6. A medical system in accordance with claim 1 wherein said elongated sleeve is constructed to slidably engage said elongated rigid implement.

7. A medical system in accordance with claim 6 wherein said elongated sleeve has a channel extending longitudinally through said elongated sleeve, said channel having dimensions suitable for slidably engaging said elongated, rigid implement.

8. A medical system in accordance with claim 1 wherein said expandable chamber comprises a balloon.

9. A medical system in accordance with claim 1 wherein said expandable chamber is mounted directly on said elongated sleeve.

10. A medical system in accordance with claim 1 wherein said heating device heats said fluid within said expandable chamber by causing electrical current to pass through a resistive pathway within said chamber.

11. A medical system in accordance with claim 10 wherein said heating device comprises a plurality of electrodes and wherein there are a plurality of elongated conductors extending through said elongated sleeve, said conductors being connected to respective ones of said plurality of electrodes to provide a radio-frequency electrical potential between said electrodes while said chamber is filled with said fluid and thereby to cause said fluid to be heated by resistive losses of electrical current passing through said fluid, said fluid being electrically conductive.

12. A method of interstitially heating a solid mass within a body of a living being, comprising the steps of:

inserting an elongated, rigid implement having a sharp distal end into said mass through a puncture site in said solid mass created by said sharp distal end,

inserting an elongated sleeve, which engages said elongated, rigid implement, into said solid mass through said puncture site in said solid mass,

providing a fluid to an expandable chamber located in the vicinity of a distal end of said elongated sleeve through at least one channel located within said elongated sleeve, to inflate said chamber while said chamber is positioned interstitially within said solid mass, and

powering, through at least one elongated conductor located within said elongated sleeve, a heating device located within said expandable chamber and connected to said at least one elongated conductor, to heat said fluid within said chamber while said chamber is filled with said fluid and is positioned interstitially within said solid mass.

16. A method in accordance with claim 12, further comprising the step of remodeling tissue within said solid mass by allowing said chamber to cool while said chamber is positioned interstitially within said solid mass.

17. A method in accordance with claim 12 further comprising the step of monitoring interstitial heating of said solid mass by non-invasive ultrasound.

18. A method in accordance with claim 12, further comprising the step of monitoring the amount of said fluid provided to said expandable chamber, as a dose parameter of interstitial heating of said solid mass.

19. A method in accordance with claim 12 further comprising the step of monitoring ischemia within said solid mass by color flow doppler imaging.

13. A method in accordance with claim further comprising the step of causing tissue surrounding said chamber to be displaced by said step of providing fluid to said expandable chamber to inflate said chamber while said chamber is positioned within said solid mass.

14. A method in accordance with claim 13, further comprising the step of causing compressive ischemia of said tissue by displacement of said tissue.

15. A method in accordance with claim 13 wherein said step of inserting said elongated sleeve into said solid mass comprises positioning said chamber in the vicinity of feeder vessels that feed tissue to be necrosed, and wherein said method comprises the step of necrosing said tissue by occluding said feeder vessels through said step of providing fluid to said expandable chamber to inflate said chamber and said step of powering said heating device.

20. A method of interstitially heating a solid mass within a body of a living being, comprising the steps of:

inserting an elongated, rigid implement having a sharp distal end into said mass through a puncture site in said solid mass created by said sharp distal end,

inserting an elongated sleeve, which engages said elongated, rigid implement, into said solid mass through said puncture site in said solid mass,

providing a fluid to an expandable chamber located in the vicinity of a distal end of said elongated sleeve through at least one channel located within said elongated sleeve, to inflate said chamber while said chamber is positioned interstitially within said solid mass,

powering, through at least one elongated conductor located within said elongated sleeve, a heating device located within said expandable chamber and connected to said at least one elongated conductor, to heat said fluid within said chamber while said chamber is filled with said fluid and is positioned interstitially within said solid mass, and

reducing a heat sink effect of said tissue surrounding said chamber during powering of said heating device by causing compressive ischemia of said tissue through said step of providing said fluid to said chamber.