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Delivery system for controlled release of bioactive factors

  • US 5,545,409 A
  • Filed: 04/05/1994
  • Issued: 08/13/1996
  • Est. Priority Date: 02/22/1989
  • Status: Expired due to Fees
First Claim
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1. A composition for the controlled release of a bioactive substance for inducing formation of cartilage or bone in an animal or wound healing comprising:

  • a. a shaped matrix sized and adapted for administration of the bioactive substance to an animal and formed of a polymer selected from the group consisting of polyanhydride and polyorthoester; and

    b. a therapeutically effective amount of a bioactive substance selected from the group consisting of water soluble chondrogenic or osteogenic proteins derived from demineralized bone matrix, TGF-beta, EGF, FGF and PDGF, wherein the bioactive substance is present in an amount of between about 10 and 90 percent by weight of matrix;

    wherein the composition erodes at a controlled rate over a period of time, thereby administering the bioactive substance to the animal in an amount effective to induce formation of cartilage and bone or wound healing.

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