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Synthetic fibronectin fragments as inhibitors of retroviral infection

  • US 5,545,620 A
  • Filed: 08/16/1994
  • Issued: 08/13/1996
  • Est. Priority Date: 01/19/1993
  • Status: Expired due to Term
First Claim
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1. A method for inhibiting HIV-1 virus infection of mammalian cells comprising contacting the cells with an effective inhibiting amount of a fibronectin fragment or carrier molecule conjugates thereof, where the fibronectin fragment amino acid sequence is selected from the group consisting of:

  • YEKPGSPPRE WPRPRPGV (FN1;

    SEQ ID NO;

    1), KNNQKSEPLI GRKKT (FN2;

    SEQ ID NO;

    2), YRVRVTPKEK TGPMKE (FN3;

    SEQ ID NO;

    3), SPPRRARVT (FN4;

    SEQ ID NO;

    4), and WQPPRARI (FN5;

    SEQ ID NO;

    5). D[P]ELPQLVTLP HPNLHGPEIL DVPST (FN6;

    SEQ ID NO;

    6), and ITVYAVTGRG DSPASSKPISI (FN7;

    SEQ ID NO;

    7).

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