Ion-induced nuclear radiotherapy

• US 5,547,454 A
• Filed: 11/02/1993
• Issued: 08/20/1996
• Est. Priority Date: 11/02/1993
• Status: Expired due to Term

• Current Assignee: Sandia Corporation (Martin Marietta Corporation)
• Original Assignee: Sandia Corporation (Martin Marietta Corporation)
• Inventors: Horn, Kevin M., Doyle, Barney L.
• Primary Examiner(s): Sykes, Angela D.
• Application Number:
  US08/147,681
• Time in Patent Office: 1,022 Days
• Field of Search: 600/1-8, 250/251
• US Class Current: 600/1
• CPC Class Codes: A61N 2005/109 Neutrons
• CPC Class Codes: A61N 5/1001 using radiation sources introduced into or applied onto the body; brachytherapy
• CPC Class Codes: A61N 5/1077 Beam delivery systems

Abstract

Ion-induced Nuclear Radiotherapy (INRT) is a technique for conducting radiosurgery and radiotherapy with a very high degree of control over the spatial extent of the irradiated volume and the delivered dose. Based upon the concept that low energy, ion induced atomic and nuclear reactions can be used to produce highly energetic reaction products at the site of a tumor, the INRT technique is implemented through the use of a conduit-needle or tube which conducts a low energy ion beam to a position above or within the intended treatment area. At the end of the conduit-needle or tube is a specially fabricated target which, only when struck by the ion beam, acts as a source of energetic radiation products. The inherent limitations in the energy, and therefore range, of the resulting reaction products limits the spatial extent of irradiation to a pre-defined volume about the point of reaction. Furthermore, since no damage is done to tissue outside this irradiated volume, the delivered dose may be made arbitrarily large. INRT may be used both as a point-source of radiation at the site of a small tumor, or as a topical bath of radiation to broad areas of diseased tissue.

Claims

1. An apparatus for ion-induced atomic and nuclear reaction-based radiotherapy comprising:

means for introducing an ion beam into a conduit means;

conduit means for guiding the ion beam and containing the beam therewithin;

transmission window means at the end of said conduit means distal to the means for introducing an ion beam, said transmission window means containing the beam with the conduit means;

target material nuclei means inside said conduit means; and

means for exposing the target material nuclei means to the ion beam for producing a nuclear reaction product for exposure to a predetermined volume external to the conduit.

2. The invention of claim 1 wherein said conduit means and said transmission window means comprise a material to minimize ancillary nuclear reactions.

3. The invention of claim 1 wherein said conduit means comprises

vacuum means.

4. The invention of claim 1 wherein said transmission window means is removable from said conduit means.

5. The invention of claim 1 wherein said target material nuclei means is affixed to said transmission window means.

6. The invention of claim 5 wherein said target material nuclei means comprises coating means on said transmission window means.

7. The invention of claim 5 wherein said transmission window means and said target material nuclei means are oriented to control a dose pattern of said reaction product.

8. The invention of claim 5 wherein said target material nuclei means comprises a thickness to maximize flux energy of the reaction product.

9. The invention of claim 1 wherein said target material nuclei means comprises a material permeated with target nuclei.

10. The invention of claim 1 wherein said target material nuclei means is independent of said transmission window means.

11. The invention of claim 10 wherein said target material nuclei means is positioned to direct said reaction product.

12. The invention of claim 10 further comprising means for removing heat from an exposure to said ion beam.

13. The invention of claim 1 wherein said conduit means comprises a first conduit means and a second conduit means.

14. The invention of claim 13 wherein said second conduit means is rotatable around a generation point of said reaction product.

15. The invention of claim 13 wherein said second conduit means comprises adjustable length means.

16. The invention of claim 13 wherein said second conduit means comprises variable aperture means on an end of said second conduit means.

17. The invention of claim 13 wherein said transmission window means is within said second conduit means.

18. The invention of claim 13 wherein said second conduit means comprises vacuum means.

19. The invention of claim 13 wherein said second conduit means is filled with a gas.

20. The invention of claim 13 wherein said target material nuclei means is affixed to a joint means between said first and second conduit means.

21. The invention of claim 1 wherein said target material nuclei means comprises deuterium.

22. The invention of claim 21 wherein said target material nuclei means comprises refractory metal deuterides.

23. The invention of claim 22 wherein said refractory metal deuterides comprises a member selected from the group consisting of deuterides, erbium, scandium, titanium, vanadium, and tantalum.

24. The invention of claim 21 wherein said deuterium comprises a thickness between approximately 0.1 and 100 microns.

25. The invention of claim 1 wherein said ion beam comprises an isotope that maximizes said reaction product.

26. The invention of claim 25 wherein said isotope comprises energy between approximately 0.1 and 2 MeV.

27. The invention of claim 1 wherein said ion beam comprises an isotope selected from the group consisting of hydrogen, helium and lithium.

28. The invention of claim 27 wherein said isotope comprises ³ He.

29. The invention of claim 28 wherein said ³ He comprises energy between approximately 0.1 and 1 MeV.

30. The invention of claim 1 wherein said reaction product comprises a member selected from the group consisting of energetic protons, gamma-rays, x-rays, neutrons, alpha particles, heavy ions, electrons and combinations thereof.

61. A method for ion-induced atomic and nuclear reaction-based radiosurgery, the method comprising the steps of:

a) targeting a treatment volume;

b) calculating a radiation dose for the volume;

c) inserting the apparatus of claim 1 into a body to a preselected location;

d) providing an ion beam to the apparatus of claim 1 for a predetermined time period.

31. A method for ion induced atomic and nuclear reaction-based radiotherapy, the method comprising the steps of:

a) providing an ion beam into one end of a conduit;

b) providing a transmission window means at the other end of the conduit for terminating a vacuum and confining the ion beam within the conduit and transmission window means;

c) providing target material nuclei within the conduit;

d) exposing the target material nuclei within the conduit;

e) producing a nuclear reaction product from exposure of the target material nuclei to the ion beam; and

f) exposing a predetermined volume to the transmitted reaction product external to the conduit.

32. The method of claim 31 wherein the steps of providing a conduit and a transmission window comprise providing a material to minimize ancillary nuclear reactions.

33. The method of claim 31 wherein the steps of providing an ion beam into one end of a conduit additionally comprises

providing a vacuum.

34. The method of claim 31 wherein the step of providing a transmission window comprises providing a removable transmission window.

35. The method of claim 31 wherein the step of providing target material nuclei comprises affixing the target material nuclei to the transmission window.

36. The method of claim 35 wherein the step of affixing target material nuclei comprises coating the target material nuclei on the transmission window.

37. The method of claim 35 further comprising the step of orienting the transmission window and target material nuclei to control a dose pattern of the reaction product.

38. The method of claim 35 wherein the step of providing target material nuclei comprises providing target material nuclei with a thickness sufficient to maximize flux and energy of the reaction product.

39. The method of claim 31 wherein the step of providing target material nuclei comprises permeating a material with target nuclei.

40. The method of claim 31 wherein the step of providing target material nuclei comprises providing target material nuclei independent of the transmission window.

41. The method of claim 40 wherein the step of providing target material nuclei comprises positioning the target material nuclei to direct the reaction product.

42. The method of claim 40 further comprising the step of removing heat from the ion beam exposure.

43. The method of claim 31 wherein the step of providing a conduit comprises providing a first conduit and a second conduit.

44. The method of claim 43 further comprising the step of rotating the second conduit around a generation point of the reaction product.

45. The method of claim 43 further comprising the step of adjusting a length of the second conduit.

46. The method of claim 43 further comprising the step of varying an aperture on an end of the second conduit.

47. The method of claim 43 further comprising the step of locating the transmission window within the second conduit.

48. The method of claim 43 further comprising the step of providing a vacuum in the second conduit.

49. The method of claim 43 further comprising the step of filling the second conduit with a gas.

50. The method of claim 43 further comprising the step of affixing the target material nuclei to a joint between the first and second conduit.

51. The method of claim 31 wherein the step of providing target material nuclei comprises providing deuterium.

52. The method of claim 51 wherein the step of providing target material nuclei comprises providing refractory metal deuterides.

53. The method of claim 52 wherein the step of providing refractory metal deuterides comprises providing a member selected from the group consisting of deuterides, erbium, scandium, titanium, vanadium, and tantalum.

54. The method of claim 51 wherein the step of providing deuterium comprises providing a thickness between approximately 0.1 and 100 microns.

55. The method of claim 31 wherein the producing step comprises the step of providing an isotope that maximizes the reaction product.

56. The method of claim 55 wherein the step of providing an isotope comprises providing energy between approximately 0.1 and 2 MeV.

57. The method of claim 31 wherein the producing step comprises the step of providing an isotope selected from the group consisting of hydrogen, helium and lithium.

58. The method of claim 57 wherein the step of providing an isotope comprises providing ³ He.

59. The method of claim 58 wherein the step of providing ³ He comprises providing ³ He with energy between approximately 0.1 and 1 MeV.

60. The method of claim 31 wherein the producing step comprises the step of producing reaction products selected from the group consisting of energetic protons, gamma-rays, x-rays, neutrons, alpha particles, heavy ions, electrons and combinations thereof.