Electrochemical sensor cartridge

• US 5,547,555 A
• Filed: 02/22/1993
• Issued: 08/20/1996
• Est. Priority Date: 02/22/1993
• Status: Expired due to Fees

• Current Assignee: Omicron Technologies, Inc. (Biomedical Research Foundation of Northwest Louisiana)
• Original Assignee: Omicron Technologies, Inc. (Biomedical Research Foundation of Northwest Louisiana)
• Inventors: Silvia, John C., Dahlin, Craig D. T., Schwartz, Jerome L., Cabelli, Michael D.
• Primary Examiner(s): Bell, Bruce F.
• Application Number:
  US08/023,774
• Time in Patent Office: 1,275 Days
• Field of Search: 204/418, 204/415, 204/412, 204/403, 422/82.05, 422/68.1, 422/82.01, 435/817, 435/288, 435/291, 435/7.1, 435/4
• US Class Current: 204/403.03
• CPC Class Codes: G01N 27/3275 Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
• CPC Class Codes: Y10S 435/817 Enzyme or microbe electrode

Abstract

An electrochemical sensor cartridge with at least three reservoir cells, the floor of each cell in leakproof contact with the surface of an electrode assembly whose conductivity is affected by the presence of an analyte in that cell.

Claims

1. An electrochemical sensor cartridge comprising an electrode assembly and at least three hollow cells, said electrode assembly being a thin flexible film that comprises (1) a first layer that is nonconducting, (2) a second layer that is a layer of metal electrodes said metal electrodes accessible to electrical contacts external to the cartridge, and (3) a third layer comprising an electroactive polymer film, said first layer below said second layer, said third layer above said second layer, wherein each hollow cell is comprised of a cell floor and a cell wall with a lower rim, wherein each cell floor is a portion of the top surface of said electrode assembly, and wherein each said lower rim is in leakproof contact with the outer perimeter of a cell floor,

wherein the cartridge is constructed from a set of parts that comprises a cover unit, a base unit, and said electrode assembly, such that the electrode assembly in the cartridge is sandwiched between the cover unit and the base unit, and wherein the cover unit and base unit are attached to each other by a securing means, and

wherein the three hollow cells are in a linear array.

2. An electrochemical sensor of claim 1 wherein each hollow cell is cylindrical in shape.

3. A cartridge of claim 2 that further comprises an overhang or canopy that covers an area above the access electrodes to prevent a drop of fluid from inadvertently falling onto the access electrodes.

4. The cartridge of claim 3 wherein the overhang has a lower segment with a front edge that is sharp and a back edge that is rounded so that a drop falling from that lower segment will fall from the sharp edge as opposed to the rounded edge and therefore not touch the electrode assembly when that assembly is in a horizontal plane.

5. An electrochemical sensor of claim 1 wherein all the cells are in a linear array.

6. An electrochemical sensor of claim 5 wherein there are three cells in a linear array.

7. An electrochemical sensor of claim 1 wherein at least three hollow cells are in a linear array parallel to a linear array of access electrodes that are electrically connected to said cells.

8. An electrochemical sensor of claim 1 wherein the three hollow cells are in a linear array parallel to a linear array of electrodes that are electrically connected to said cells.

9. A cartridge of claim 1 that covers an area above the access electrodes to prevent a drop of fluid from inadvertently falling onto the access electrodes.

10. The cartridge of claim 9 wherein the overhang has a lower segment with a front edge that is sharp and a back edge that is rounded so that a drop falling from that lower segment will fall from the sharp edge as opposed to the rounded edge and therefore not touch the electrode assembly when that assembly is in a horizontal plane.

11. A cartridge of claim 1 wherein the second layer of the electrode assembly comprises a set of parallel metal strips, each metal strip separated from the others, each metal strip comprising a first region that serves as a cell electrode, a second region that serves as a connector, a third that serves as an access electrode, the first region contiguous with the second region, the second region contiguous with the third region.

12. An electrochemical sensor of claim 11 wherein each hollow cell is cylindrical in shape.

13. An electrochemical sensor of claim 11 wherein the three hollow cells are in a linear array parallel to a linear array of access electrodes that are electrically connected to said cells.

14. A cartridge of claim 11 that further comprises an overhang or canopy that covers an area above the access electrodes so as to prevent a drop of fluid from inadvertently falling onto the access electrodes.

15. The cartridge of claim 14 wherein the overhang has a lower segment with a front edge that is sharp and a back edge that is rounded so that a drop falling from that lower segment will fall from the sharp edge as opposed to the rounded edge and therefore not touch the electrode assembly when that assembly is in a horizontal plane.

16. An electrochemical sensor cartridge of claim 1 wherein the electroactive polymer is selected from the group consisting of polyacetylene, polypyrrole, polythiophene, poly(3-alkylthiophene), polyphenylene sulfide, polyphenylene vinylene, polythienylene vinylene, polyphenylene, polyisothanonaphthene, polyazulene, polyfuran, polyanaline, and a derivative thereof.

17. An electrochemical sensor of claim 1 wherein the securing means is a screw or a latch.

18. An electrochemical sensor of claim 1 wherein the securing means is a latch.