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Method of monitoring patient compliance with medications prescriptions

  • US 5,547,878 A
  • Filed: 05/24/1994
  • Issued: 08/20/1996
  • Est. Priority Date: 11/02/1993
  • Status: Expired due to Term
First Claim
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1. A method of monitoring compliance of a patient that has been placed on a medication maintenance program with a prescribed medication dosage, and with the method comprising the steps of(a) obtaining a sample of the patient'"'"'s urine,(b) measuring the concentration of the medication or its metabolites in the urine and the urine specific gravity,(c) calculating a normalized urine medication concentration as a function of the measured medication concentration in the urine and the urine specific gravity in accordance with the equation


  • space="preserve" listing-type="equation">un=u·

    (k.sub.1 ·

    SGF-k.sub.2)
where nu is the normalized urine medication concentration, u is the measured concentration of medication in the urine, SGF is the specific gravity factor of the urine sample, and k1 and k2 are constants, and(d) comparing the normalized urine medication concentration with an expected medication concentration value for the patient for the maintenance program prescribed to determine any significant differences therebetween as an indication of noncompliance.

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