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Composition for introducing nucleic acid complexes into higher eucaryotic cells

  • US 5,547,932 A
  • Filed: 09/23/1992
  • Issued: 08/20/1996
  • Est. Priority Date: 09/30/1991
  • Status: Expired due to Term
First Claim
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1. A process for introducing nucleic acid into the cytoplasm of a higher eucaryotic cell, which comprises contacting the cell with a composition of matter which comprises a complex, wherein said complex comprises(a) a nucleic acid of interest,(b) a substance having affinity for nucleic acid, and(c) an endosomolytic agent, whereby said complex is internalized into the cell by endocytosis, and is released into the cytoplasm of said cell by endosomolysis.

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