Controlled release of steroids from sugar coatings

• US 5,547,948 A
• Filed: 01/17/1995
• Issued: 08/20/1996
• Est. Priority Date: 01/17/1995
• Status: Expired due to Term

• Current Assignee: Wyeth (Pfizer Inc.)
• Original Assignee: American Home Products Corporation (Pfizer Inc.)
• Inventors: Barcomb, Reginald J.
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US08/373,667
• Time in Patent Office: 581 Days
• Field of Search: 424/479, 514/170, 514/171
• US Class Current: 514/170
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/565 not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
• CPC Class Codes: A61K 31/566 having an oxo group in position 17, e.g. estrone
• CPC Class Codes: A61K 31/567 substituted in position 17 alpha, e.g. mestranol, norethandrolone
• CPC Class Codes: A61K 31/568 substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
• CPC Class Codes: A61K 31/569 substituted in position 17 alpha, e.g. ethisterone
• CPC Class Codes: A61K 31/57 substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
• CPC Class Codes: A61K 31/575 substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
• CPC Class Codes: A61K 9/2018 Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
• CPC Class Codes: A61K 9/2054 Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
• CPC Class Codes: A61K 9/2086 Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat active cores with a complete drug-free outer coat A61K9/28
• CPC Class Codes: A61K 9/209 containing drug in at least two layers or in the core and in at least one outer layer
• CPC Class Codes: A61P 5/30 Oestrogens

Abstract

A sugar coating composition for application to a compressed medicinal tablet comprising a sugar, a dose of a hormonal steroid and a steroid release rate controlling amount of microcrystalline cellulose.

Claims

1. A compressed tablet comprising a tablet core containing conjugated estrogens and a sugar coating in which said sugar coating incorporates a hormonal steroid and a release rate controlling amount of microcrystalline cellulose.

2. A compressed tablet of claim 1 in which said tablet core contains from about 0.1 to about 5.0 milligrams of conjugated estrogens and said sugar coating contains from about 1.0 to about 50 milligrams of said hormonal steroid.

3. A compressed tablet of claim 1 in which said tablet core contains from about 0.3 to about 2.5 milligrams of conjugated estrogens and said sugar coating contains about 1.5 to about 30 milligrams of medroxyprogesterone acetate.

4. A compressed tablet comprising a tablet core containing conjugated estrogens and a sugar coating in which said sugar coating incorporates with the sugar sucrose, the hormonal steroid medroxyprogesterone acetate and asteroid release rate controlling amount of microcrystalline cellulose.

5. A compressed tablet of claim 4 in which said tablet core contains from about 0.1 to about 5.0 milligrams of conjugated estrogens and said sugar coating contains from about 1 to about 50 milligrams of medroxyprogesterone acetate.

6. A compressed tablet of claim 4 in which said tablet core contains from about 0.3 to about 2.5 milligrams of conjugated estrogens and said sugar coating contains about 2.5 to about 30 milligrams of medroxyprogesterone acetate.