Cartridge assembly for use in a pen-type medicament injector

• US 5,549,574 A
• Filed: 08/30/1994
• Issued: 08/27/1996
• Est. Priority Date: 08/30/1994
• Status: Expired due to Fees

• Current Assignee: Eli Lilly and Company
• Original Assignee: Eli Lilly and Company
• Inventors: Townsend, Michael W.
• Primary Examiner(s): Yasko, John D.
• Assistant Examiner(s): STRIGHT, RONALD K
• Application Number:
  US08/298,117
• Time in Patent Office: 728 Days
• Field of Search: 604/232, 604/218, 604/82, 604/89, 604/90, 604/234, 604/228, 604/220-222, 604/91, 604/225, 604/244, 604/256, 604/199-202, 604/80-91, 604/416, 604/903, 604/205 , 604/206, 604/219-222, 366/129, 366/256, 366/289, 366/317, 366/332, 215/DIG. 3, 215/DIG. 8
• US Class Current: 604/232
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/31596 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: Y10S 215/03 Medical
• CPC Class Codes: Y10S 215/08 Mixing
• CPC Class Codes: Y10S 604/903 Medical container with material agitation means

Abstract

A cartridge assembly for use in a pen-type medicament injector includes a cartridge for holding a medicament suspension with an open end and an opposite capped end configured to receive a needle therethrough to permit the exit of the medicament suspension, and includes a plunger sized to be received and to seal the open end and to be telescopically movable therein, and the plunger defining a top surface and including at least one monolithic mixing vane formed therefrom and extending from the top surface and inwardly of the cartridge when the plunger is sealingly engaged with the open end.

Claims

1. A cartridge assembly for use in a pen-type medicament injector, comprising:

a cartridge for holding liquid medicament and having an open end and having an opposite capped end, the opposite capped end comprising a pierceable material operable to seal shut the capped end and to receive a needle therethrough to permit the exit of the liquid medicament; and

a plunger sized to be received and to seal the open end and to be telescopically movable within the cartridge, said plunger defining a top surface and including at least one monolithic mixing vane formed therefrom and extending from said surface and inwardly of said cartridge when said plunger is sealingly engaged within the open end.

2. The cartridge assembly of claim 1 wherein the top surface defines a circumferential periphery and said plunger has a central axis and said at least one mixing vane has a height which is greater nearer to the circumferential periphery than to the central axis.

3. The cartridge assembly of claim 2 wherein said at least one mixing vane has the shape of a one-quarter section of an ellipse.

4. The cartridge assembly of claim 3 wherein there are four of said at least one mixing vanes.

5. The cartridge assembly of claim 1 wherein the top surface has a diameter and said at least one mixing vane has a height equal to or greater than one sixteenth of the diameter of the top surface.

6. The cartridge assembly of claim 5 wherein the height of said at least one mixing vane is equal to or greater than one sixth the diameter of the top surface.

7. The cartridge assembly of claim 1 wherein said plunger has a central axis and there are four of said at least one mixing vanes, the four mixing vanes extending radially and being circumferentially spaced about the axis.

8. The cartridge assembly of claim 7 wherein said top surface is substantially flat and perpendicular to the central axis.

9. The cartridge assembly of claim 1 wherein the top surface defines a circumferential periphery and a diameter, and wherein said plunger has a central axis and wherein said at least one mixing vane includes two generally rectangular mixing vanes, and wherein each mixing vane extends tangentially toward the outer periphery from a circle coaxial with the central axis and having a diameter greater than zero and less than the diameter of the top surface.

10. The cartridge assembly of claim 9 wherein the circle has a diameter between one tenth and one fifth of the diameter of the top surface.

11. The cartridge assembly of claim 9 wherein each mixing vane has a height which is greater at points farther from the central axis than nearer to the central axis.

12. The cartridge assembly of claim 1 wherein the top surface defines a circumferential periphery and said at least one mixing vane extends radially outwardly to the periphery.

13. The cartridge assembly of claim 1 wherein said at least one mixing vane is a single, rectangular shaped vane extending diametrically across the top surface of said plunger.

14. The cartridge assembly of claim 1 wherein the top surface defines a circumferential periphery and wherein said at least one mixing vane is a single vane in the shape of a cross extending radially outwardly to the circumferential periphery.

15. The cartridge assembly of claim 1 wherein the top surface defines a circumferential periphery and said at least one mixing vane includes four ramped mixing vanes each having the shape of a triangular polyhedron with the outer corner rounded off by the circumferential periphery.

16. The cartridge assembly of claim 1 wherein said cartridge contains a medicament suspension and is essentially bubble-free.

17. A cartridge assembly for use in a pen-type medicament injector, comprising:

a cylindrical cartridge for holding liquid medicament and having a first sealed end and an opposing open end, the first sealed end comprising a pierceable material operable to seal shut the first end, but to permit a needle to pierce and extend through the material and into the cartridge to access the medicament; and

a plunger sized to be received and seal the open end and to be telescopically movable within said cartridge, said plunger defining a top surface and having at least one monolithic mixing vane formed therefrom and extending upwardly from said top surface to a height of at least 0.4 mm.

18. The cartridge assembly of claim 17 wherein there are four mixing vanes extending radially from the central axis.

19. A cartridge assembly for use in a pen-type medicament injector, comprising:

a cylindrical cartridge for holding liquid medicament and having a first sealed end and an opposing open end, the first sealed end comprising a pierceable material operable to seal shut the first end, but to permit a needle to pierce and extend through the material and into the cartridge to access the medicament; and

a plunger sized to be received and seal the open end and to be telescopically movable within said cartridge, said plunger defining a top surface and having at least one mixing vane extending upwardly from the top surface to form an angle with the top surface which is less then 90°

.

20. A cartridge assembly of claim 19 wherein there are four mixing vanes extending upwardly from the top surface and forming angles with the top surface which are less than 90°

.