Method and apparatus for ophthalmic surgery

• US 5,549,632 A
• Filed: 10/26/1992
• Issued: 08/27/1996
• Est. Priority Date: 10/26/1992
• Status: Expired due to Term

• Current Assignee: AMO Development LLC (Johnson & Johnson)
• Original Assignee: Novatec Laser Systems Incorporated
• Inventors: Lai, Shui T.
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): HARRIS, SONYA C
• Application Number:
  US07/967,253
• Time in Patent Office: 1,401 Days
• Field of Search: 606/4, 606/5, 606/6, 606/19, 606/10, 606/11, 606/12, 606/15
• US Class Current: 606/5
• CPC Class Codes: A61B 2017/00694 with means correcting for movement of or for synchronisation with the body
• CPC Class Codes: A61B 2017/306 holding by means of suction
• CPC Class Codes: A61F 2009/00846 Eyetracking
• CPC Class Codes: A61F 2009/00863 Retina
• CPC Class Codes: A61F 2009/0087 Lens
• CPC Class Codes: A61F 2009/00872 Cornea
• CPC Class Codes: A61F 2009/00876 Iris
• CPC Class Codes: A61F 9/00825 for photodisruption
• CPC Class Codes: A61F 9/009 Auxiliary devices making contact with the eyeball and coupling in laser light, e.g. goniolenses apparatus for eye examination A61B3/0008

Abstract

A method and apparatus for precisely controlling and determining the location of the interaction point of a surgical laser beam, and for controlling the shape of the cornea during ophthalmic surgery. A transparent applanator plate is placed in contact with the cornea of a patient'"'"'s eye. The applanator plate creates a fixed positional frame of reference from which a laser beam control system can determine the desired point or points at which to focus the surgical laser beam. A surgical tip at the distal end of an articulated arm having flexible joints is placed in contact with the applanator plate and follows any motion of the patient'"'"'s eye and directs the laser beam to the surgical tip. The applanator plate also provides a means to control the contour of the index of refraction boundary between the corneal epithelium of the patient'"'"'s eye and the air.

Claims

1. An ophthalmic surgical system for performing surgery upon an eye having an outer surface, the ophthalmic surgical system including:

a. a laser source for generating a laser beam suitable for ophthalmic surgery;

b. a controller, optically coupled to the laser beam, for controlling positioning of the laser beam;

c. a delivery system having a proximal end and a movable distal end, the proximal end being coupled to the laser source for guiding the laser beam to the distal end of the delivery system;

d. a surgical tip at the distal end of the delivery system for directing the laser beam into an interaction point or tan area having a location, the location of the interaction point being determined by the controller; and

e. an applanator plate adapted to be rigidly attached to the eye and to the surgical tip, the applanator plate providing a fixed positional reference in three-dimensional space with respect to the laser beam interaction point in the eye to allow three-dimensional control of the interaction point in the eye by the laser source and controller.

3. The ophthalmic surgical system of claim 1 or 2, wherein the applanator plate is made of a material having an index of refraction substantially equivalent to the index of refraction of a cornea of an eye so as to produce essentially no distortion of the laser beam at the boundary between the applanator plate and the outer surface of the eye.

4. The ophthalmic surgical system of claim 1, wherein the delivery system includes an articulated arm means having flexible joints, disposition of which determines a path along which the laser beam propagates from the laser source, for permitting limited motion of the eye with respect to the laser source while preventing the eye from moving with respect to the surgical tip.

5. The ophthalmic surgical system of claim 4, wherein the articulated arm comprises a series of reflective optical elements and lenses positioned to determine the path of the laser beam.

6. The ophthalmic surgical system of claims 1 or 2, wherein the surgical tip includes at least one movable lens, and the location of the interaction point of the laser beam is determined with respect to a three-dimensional positional frame of reference that is fixed relative to the surgical tip by moving at least one lens within the surgical tip.

7. The ophthalmic surgical system of claims 1 or 2, further including an applanator plate retention device, coupled to the applanator plate and configured to be coupled to a scleral-corneal region of the eye, for preventing motion of the applanator plate relative to the eye during eye surgery.

8. The ophthalmic surgical system of claim 7, further including a vacuum generation system, coupled to the applanator plate retention device, for creating a vacuum sufficient to retain the applanator plate retention device motionless relative to the eye.

9. The ophthalmic surgical system of claims 1 or 2, wherein the eye includes a cornea, and the ophthalmic surgical procedure is selected from the group consisting of:

a. radial keratotomy;

b. generating transverse cuts in the cornea;

c. creating straight line excisions in the cornea;

d. creating curved-line excisions in the cornea;

e. creating multiple radial cuts, equal or partially equal in excision length and with an angular separation between cuts, made on the cornea;

f. creating a curved channel excision in the cornea;

g. creating a point excision in the cornea;

h. creating an interrupted line excision in the cornea;

i. creating a curved excision of varying depth in the cornea;

j. removing a geometric area from the cornea;

k. creating a spiral excision in the cornea;

l. creating holes in the posterior capsule of the eye;

m. creating holes in the anterior capsule of the eye;

n. creating holes in an iris of the eye;

o. cutting retinal membranes;

p. producing sculpted cornea caps in advance of need;

q. sculpting the cornea according to a predetermined shape;

r. removing cornea tissue in increasing thickness from the center portion out towards the periphery of the cornea;

s. selectively ablating the cornea in such a way that more tissue is removed at the center portion of the cornea, with a decreasing amount of tissue being removed towards the periphery of the cornea; and

t. removing tissue from the eye.

10. The ophthalmic surgical system of claims 1 or 2, wherein at least one shaped surface of the applanator plate is planar.

11. The ophthalmic surgical system of claims 1 or 2, wherein at least one shaped surface of the applanator plate is concave.

12. The ophthalmic surgical system of claims 1 or 2, wherein at least one shaped surface of the applanator plate is convex.

13. The ophthalmic surgical system of claim 1 or 2, wherein at least one shaped surface of the applanator plate is spherical.

14. The ophthalmic surgical system of claims 1 or 2, wherein at least one shaped surface of the applanator plate is aspherical.

15. The ophthalmic surgical system of claim 1, wherein the controller controls the three-dimensional location of the interaction point of the laser beam.

16. The ophthalmic surgical system of claim 15, wherein the beam scanning system includes a lens positioning system for controlling the three-dimensional location of the interaction point of the laser beam.

17. The ophthalmic surgical system of claim 15, wherein the beam scanning system includes at least one galvanometric scanner.

18. The ophthalmic surgical system of claim 15, wherein the beam scanning system includes manual movement of the surgical tip.

19. The ophthalmic surgical system of claim 1, wherein the surgical tip is aged to the applanator plate.

2. An ophthalmic surgical system for performing surgery upon an eye having an outer surface, the ophthalmic surgical system including:

a. a laser source for generating a laser beam suitable for ophthalmic surgery;

b. a controller, optically coupled to the laser beam, for controlling positioning of the laser beam;

c. a delivery system having a movable distal end and proximal end, the proximal end being coupled to the laser source, for guiding the laser beam to the distal end of the delivery means;

d. a surgical tip at the distal end of the delivery system for directing the laser beam into an interaction point or an area having a location, the location of the interaction point being determined by the controller; and

e. an applanator plate, the a planator plate having at least one shaped surface means, the surgical tip being in contact with the applanator plate during surgery on an eye, the shaped surface means being placed in contact with of the outer surface of the eye during surgery on the eye, the shaped surface means for defining a predetermined area of the eye for a surgical procedure to be performed in such area and for conforming the predetermined area of the eye to the shaped surface of the shaped surface means, such conformed predetermined area providing a positional reference in three-dimensional space with respect to the laser beam interaction point in the eye to allow three-dimensional control of the interaction point in the eye by the laser source and controller, wherein the shaped surface means displaces the outer surface of the eye such that lineal or non-lineal excisions made while the applanator plate is in contact with the eye transform to non-lineal excisions upon removal of the applanator plate from the eye.

20. An ophthalmic surgical system for performing ophthalmic surgery upon an eye having an outer surface, the ophthalmic surgical system including:

a. a laser source for generating, and controlling positioning of, a laser beam suitable for ophthalmic surgery;

b. a delivery system having a proximal end and a movable distal end, the proximal end being coupled to the laser source, for guiding the laser beam to the distal end of the delivery system;

c. a surgical tip at the distal end of the delivery system, for focussing the laser beam into an area having a size and location, the size and location of the area being determined by the control means of the laser source with respect to a three-dimensional positional frame of refer, race that is fixed relative to the distal end of the delivery system; and

an applanator plate, adapted to be rigidly attached to a portion of the outer surface of an eye during surgery, the surgical tip being rigidly attached to the applanator plate during such surgery, the applanator plate thus fixing the three-dimensional positional frame of reference relative to the outer surface of the eye to provide precision three-dimensional reference of an interaction point between tissue of the eye and the laser beam.

21. The ophthalmic surgical system of claim 20, further including a fiber optic path for guiding the laser beam from the laser source to the delivery system.

22. The applanator plate of claim 20, wherein the applanator plate is made of a material having an index of retraction substantially equivalent to the index of refraction of a cornea of a human eye so as to produce essentially no distortion in the laser beam at the boundary between the applanator plate and the outer surface of the eye.

23. The applanator plate of claim 20, further including an applanator plate retention device, coupled to the applanator plate and configured to be coupled to a scleral-corneal region of the eye, for preventing motion of the applanator plate relative to the eye during eye surgery.

24. An applanator plate having a means for fixing the applanator plate to an eye and at least one shaped surface means for contacting and displacing an outer surface of an eye upon which ophthalmic surgery is to be performed, and for conforming the outer surface of the eye to the shape of the contacting shaped surface means, and having a second shaped surface configured to be placed in contact with a tip of a surgical laser instrument having a three-dimensional position, the applanator plate fixing the three-dimensional position of the laser surgical instrument relative to the eye and precisely coupling the laser beam from the laser surgical instrument to selected locations in the eye.

25. The applanator plate of claim 24, wherein at least one of the opposed surfaces is planar.

26. The applanator plate of claim 24, wherein at least one of the opposed surfaces is concave.

27. The applanator plate of claim 24, wherein at least one of the opposed surfaces is convex.

28. The applanator plate of claim 24, wherein at least one of the opposed surfaces is spherical.

29. The applanator plate of claim 24, wherein at least one of the opposed surfaces is aspherical.

30. A method of ophthalmic surgery, including the steps of:

e. generating a laser beam from a laser source;

f. directing the laser beam through at least one optical element from the laser source to a surgical tip;

g. contacting a first surface of an applanator plate to a portion of the outer surface of an eye such that the portion of the outer surface of the eye is displaced to conform to the shape of the first surface of the applanator plate, such contact between the applanator plate and the eye thereby defining an area through which the laser beam interacts with tissue of the eye;

h. rigidly attaching the surgical tip to a second surface of the applanator plate; and

i. focusing the laser beam from the surgical tip through the applanator plate to at a plurality of predetermined locations in the eye, each such location having a fixed three-dimensional reference with respect to the applanator plate, the focused laser beam interacting with eye tissue at each such location.

31. The method of ophthalmic surgery in claim 30, wherein the first surface of the applanator plate has one of a plano, aspherical, spherical, concave, or convex shape.

32. The method of ophthalmic surgery in claim 30, wherein the second surface of the applanator plate has one of a plano, aspherical, spherical, concave, or convex shape.

33. The method of ophthalmic surgery in claim 30, further including the step of controlling the three-dimensional location of the laser beam in the eye by means of a beam scanning means.

34. The method of ophthalmic surgery in claim 33, wherein the beam scanning means includes at least one galvanometer drive and at least one mirror.

35. The method of ophthalmic surgery in claim 33, wherein the beam scanning system includes a lens positioning system for controlling the three-dimensional location of the interaction point of the laser beam.

36. The method of ophthalmic surgery in claim 33, wherein the beam scanning system includes manual movement of the surgical tip.

37. The method of ophthalmic surgery in claim 30, wherein the applanator plate is attached to the eye by means of a suction device.

38. The method of ophthalmic surgery in claim 30, further including the step of directing the laser beam by means of an articulated arm defining an optical path from the laser source to the surgical tip.

39. The method of ophthalmic surgery in claim 30, further including the step of directing the laser beam by means of a fiber optic path from the laser source to the surgical tip.

40. The method of ophthalmic surgery in claim 30, wherein the interaction of the laser beam with eye tissue includes ablation of eye tissue.

41. The method of ophthalmic surgery in claim 30, further including the steps of:

a. focussing the laser beam at a location in the eye, such location including at least one of the anterior or the posterior capsule of the eye, the lens of the eye, or the retina of the eye;

b. excising eye tissue at the focus location with the laser beam; and

c. scanning the location of the focussed laser beam along a predetermined direction, over a predetermined area, or inside a predetermined volume inside the eye.

42. The method of ophthalmic surgery in claim 30, wherein the interaction of the laser beam with eye tissue includes heating eye tissue.

43. The method of ophthalmic surgery in claim 30, further including the steps of:

a. focussing the laser beam at a location in the eye, such location including at least one of the anterior or the posterior capsule of the eye, the lens of the eye, or the retina of the eye;

b. heating eye tissue at the focus location with the laser beam; and

c. scanning the location of the focussed laser beam along a predetermined direction, over a predetermined area, or inside a predetermined volume inside the eye.

44. The method of ophthalmic surgery in claim 30, wherein the interaction of the focussed laser beam with eye tissue attains an objective of changing the refractive power of the eye by the steps of:

a. locating the focussed laser beam at one of the epithelium, Bowman'"'"'s layer, or stroma of the eye;

b. excising eye tissue at the focus location with the laser beam; and

c. scanning the location of the focussed beam along a predetermined direction, over a predetermined area, or inside a predetermined volume of the eye.

45. The method of ophthalmic surgery in claim 44, wherein the excised tissue volume is on the outer surface of the cornea of the eye.

46. The method of ophthalmic surgery in claim 44, wherein the excised tissue volume is inside the cornea of the eye.

47. The method of ophthalmic surgery in claim 46, wherein the excised tissue volume comprises a cavity, and further including the step of collapsing the cavity to change the curvature of the portion of the outer surface of the eye.

48. The method of ophthalmic surgery in claim 47, further including the step of collapsing the cavity by compressing the outer surface of the cornea with the applanator plate.

49. The method of ophthalmic surgery in claim 44, wherein the objective is to correct myopia conditions, and further includes the step of excising a tissue volume in the eye which has a shape substantially equivalent to a positive lens, with the intended optical axes of such lens shape being aligned along the visual axes of the eye;

thereby flattening the curvature of the portion of the outer surface of the eye.

50. The method of ophthalmic surgery in claim 44, wherein the objective is to correct hyperopia conditions, and further includes the step of excising a tissue volume in the eye which has a shape substantially equivalent to a negative lens with an outer periphery tapered to essentially a zero thickness, with the intended optical axes of such lens shape being aligned along the visual axes of the eye, thereby steepening the curvature of the portion of the outer surface of the eye.

51. The method of ophthalmic surgery in claim 44, wherein the objective is to perform a procedure to correct the refractive power, further including the steps of:

f. contacting an applanator plate having a first surface of a predetermined concave curvature to the portion of the outer surface of the eye, thereby displacing the surface of the eye to conform the portion of the outer surface of the eye to the same curvature;

g. applying the focused laser beam to the eye; and

h. excising eye tissue on one or more planes at a predetermined angle with respect to the visual axes of the eye, such that the excision separates a layer of eye tissue defined by the planes and the first surface of the applanator plate.

52. The method of ophthalmic surgery in claim 51, wherein the separated tissue layer has the shape substantially equivalent to a plano lens with predetermined area and thickness.

53. The method of ophthalmic surgery in claim 51, wherein the separated tissue layer has the shape substantially equivalent to a positive lens with predetermined area and thickness.

54. The method of ophthalmic surgery in claim 51, wherein the separated tissue layer has the shape substantially equivalent to a negative lens with predetermined area and thickness.

55. The method of ophthalmic surgery in claim 51, further including the steps of:

a. removing the separated layer of eye tissue;

b. ablating the stroma bed of the eye to remove a tissue volume essentially in the shape of a plano lens of any predetermined profile;

c. replacing the separated layer of eye tissue such that the curvature of the portion of the outer surface of the eye is modified.

56. The method of ophthalmic surgery in claim 51, further including the steps of:

a. removing the separated layer of eye tissue;

b. ablating the stroma bed of the eye to remove tissue volume essentially in the shape of a positive lens;

c. replacing the separated layer of eye tissue such that the curvature of the portion of the outer surface of the eye is modified.

57. The method of ophthalmic surgery in claim 51, further including the steps of:

a. removing the separated layer of eye tissue;

b. ablating the stroma bed of the eye to remove tissue volume essentially in the shape of a negative lens;

c. replacing the separated layer of eye tissue such that the curvature of the portion of the outer surface of the eye is modified.

58. The method of ophthalmic surgery in claim 51, further including the steps of:

a. removing the separated layer of eye tissue;

b. ablating the posterior surface of the separated layer of eye tissue to remove a tissue volume essentially in the shape of a plano lens;

c. replacing the separated layer of eye tissue, such that the curvature of the portion of the outer surface of the eye is modified.

59. The method of ophthalmic surgery in claim 51, further including the steps of:

a. removing the separated layer of eye tissue;

b. ablating the posterior surface of the separated layer of eye tissue to remove a tissue volume essentially in the shape of a positive lens;

c. replacing the separated layer of eye tissue, such that the curvature of the portion of the outer surface of the eye is modified.

60. The method of ophthalmic surgery in claim 51, further including the steps of:

a. removing the separated layer of eye tissue;

b. ablating the posterior surface of the separated layer of eye tissue to remove a tissue volume essentially in the shape of a negative lens;

c. replacing the separated layer of eye tissue, such that the curvature of the portion of the outer surface of the eye is modified.

61. The method of ophthalmic surgery in claim 30, wherein the ophthalmic surgical procedure is selected from the group consisting of:

a. radial keratotomy;

b. generating transverse cuts in the cornea;

c. creating straight line excisions in the cornea;

d. creating curved-line excisions in the cornea;

e. creating multiple radial cuts, equal or partially equal in excision length and with an angular separation between cuts, made on the cornea;

f. creating a curved channel excision in the cornea;

g. creating a point excision in the cornea;

h. creating an interrupted line excision in the cornea;

i. creating a curved excision of varying depth in the cornea;

j. removing a geometric area from the cornea;

k. creating a spiral excision in the cornea;

l. creating holes in the posterior capsule of the eye;

m. creating holes in the anterior capsule of the eye;

n. creating holes in an iris of the eye;

o. cutting retinal membranes;

p. producing sculpted cornea caps in advance of need;

q. sculpting the cornea according to a predetermined shape;

r. removing cornea tissue in increasing thickness from the center portion out towards the periphery of the cornea;

s. selectively ablating the cornea in such a way that more tissue is removed at the center portion of the cornea, with a decreasing amount of tissue being removed towards the periphery of the cornea; and

t. removing tissue from the eye.